Thieno[2,3-d]pyrimidin-4(3H)one

Thieno[2,3-d]pyrimidin-4(3H)-one serves primarily as a privileged core scaffold in medicinal chemistry and drug discovery. Because it is a structural analog and bioisostere to purine bases (like adenine) and quinazoline alkaloids, modifying this chemical backbone allows researchers to develop highly targeted therapeutic agents. [1, 2, 3, 4, 5]

• Appearance: Typically a white, light yellow to light brown crystalline powder.
• Molecular Formula: \(C_{6}H_{4}N_{2}OS\)
• Molecular Weight: 152.17
• CAS Number: 14080-50-3
• Melting Point: Approximately 245 °C to 265 °C (with decomposition).
• Boiling Point: Approximately 391.1 ± 15.0 °C (predicted at 760 mmHg).
• Density: Approximately 1.6 ± 0.1 \(g/cm^3\).
• Solubility: Slightly soluble in water.

• Stability: Relatively stable under ambient temperature and pressure, but sensitive to intense light and high heat (prone to decomposition).
• Storage Conditions: Recommended to be stored in a refrigerator at 2–8 °C, protected from light, sealed, and kept dry.