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Lithocholic Acid High-Purity Secondary Bile Acid for Metabolic, Gut Microbiome, and FXR Signaling Research

Name: Lithocholic Acid High-Purity Secondary Bile Acid for Metabolic, Gut Microbiome, and FXR Signaling Research
Brand: ONERBIO
SKU: pr2606021236
Price: 10.19 USD
Availability: InStock

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CAS No.:

434-13-9

Grade:

Pharmaceutical Grade

Content:

99%

Port:

Shanghai

Brand:

ONERBIO

Packaging:

25kg/drum

Price valid (until):

2026-08-27

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Wuhan Oner Biotech Co.,Ltd.

Company Type:

Distributor

Location:

China

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Main Products:

Nutrition supplement material,Pharmaceutical raw material,Chemical raw material

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Product Description
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Description

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Product Name: Lithocholic Acid
CAS Number: 434-13-9
Molecular Formula: C₂₄H₄₀O₃
Molecular Weight: 376.58 g/mol
Appearance: White to off-white crystalline powder.

Lithocholic Acid (CAS 434-13-9) is a naturally occurring secondary bile acid produced by bacterial 7α-dehydroxylation of chenodeoxycholic acid in the intestinal tract. As one of the most hydrophobic bile acids, it serves as a critical signaling molecule involved in the regulation of lipid metabolism, glucose homeostasis, and energy expenditure through activation of the nuclear receptor FXR (farnesoid X receptor) and the G-protein-coupled receptor TGR5. Its unique physicochemical properties and biological activities make it an indispensable tool compound in gastroenterology, hepatology, and metabolic disorder research, particularly in studies related to cholestasis, inflammatory bowel disease, and colorectal cancer pathogenesis. Additionally, Lithocholic Acid is widely utilized in the synthesis of bile acid derivatives, drug delivery systems, and as a reference standard in analytical method development. Supplied as a white to off-white crystalline powder with high purity and consistent quality, it is suitable for advanced biochemical research, pharmaceutical intermediate synthesis, and GMP-compliant production processes requiring reliable batch-to-batch reproducibility.

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ITEMS	STANDARDS		RESULTS
Description	White to almost white powder		White powder
UV absorbance ratio	A250/A260 A280/A260	0.41-0.49 2.03-2.71	0.45 2.14
PH	2.0-4.0		2.68
Loss on drying	≤5.0%		2.64%
Assay (UV)	≥98.0%		99.17%
Transmittance	≥98.5%		99.1%
Heavy metals	≤10ppm		＜10ppm
Purity (HPLC)	≥98.0%		99.6%
Conclusion	It complies to the standard

For regulatory compliance (e.g., USP, EP, JP), raw material Vidarabine must meet several rigorous standards:

Assay (by HPLC): 98.0% – 102.0% on an anhydrous basis.
Related Substances: Limits for specific impurities, notably Ara-Hx (NMT 2.0%), as well as any unspecified individual impurity (NMT 0.1%) and total impurities (NMT 2.0%).
Residual Solvents: Must comply with ICH Q3C guidelines (Class 1 and 2 solvents limited or absent).
Heavy Metals: NMT 20 ppm (typically lower for injectable grades).
Water Content (Karl Fischer): NMT 6.0% (the material is hygroscopic to a degree).
Microbial Limits: Total aerobic microbial count (TAMC) ≤ 1000 CFU/g, absence of S. aureus, P. aeruginosa, and Candida albicans.

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As a high-purity pharmaceutical intermediate, L-Tyrosine Ethyl Ester Hydrochloride is predominantly utilized in the chemical synthesis of bioactive peptides, dopamine analogs, and melanin precursors. Its excellent solubility profile makes it an ideal chiral building block for asymmetric synthesis and a critical substrate in enzymatic reactions. Available in purity grades of ≥98% (HPLC), it meets stringent requirements for R&D and cGMP manufacturing processes. Reliable supply ensures batch-to-batch consistency for long-term project scalability.

Vidarabine is classified as a potential reproductive hazard and an irritant. Safety Data Sheets (SDS) mandate the following:

Hazard Statements (H360): May damage fertility or the unborn child (Category 1B).
Precautionary Measures: Use fume hoods and wear impermeable gloves (e.g., nitrile), lab coats, and safety goggles. Avoid generating airborne dust.
First Aid: In case of skin contact, wash immediately with copious soap and water. If inhaled, move to fresh air.
Storage: Store in tightly sealed, light-resistant containers at 2°C to 8°C (refrigerated) for long-term stability. Avoid freezing.

While superseded by newer nucleoside analogs (Acyclovir, Ganciclovir) for systemic use due to better bioavailability and lower toxicity, Vidarabine retains niche value. Its primary current application is ophthalmic ointment (3%) . Pharmacokinetically, the raw material has poor oral bioavailability (<10%) and is rapidly deaminated in the gastrointestinal tract, necessitating parenteral or topical administration.

Vidarabine API is a well-characterized, stable crystalline nucleoside analog. While its systemic use has declined, it remains a critical raw material for topical antiviral ophthalmic preparations, particularly where resistance to other agents occurs. Manufacturers must strictly control impurities (especially Ara-Hx) and water content to ensure final drug product efficacy.

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ECHEMI Editorial Reference

Lithocholic acid is a toxic secondary bile acid, causes intrahepatic cholestasis, has tumor-promoting activity.Target: OthersLithocholic acid has been used in a study to assess cholestasis and its action on several organs and tissues in rats. It has also been used in a study to investigate the regulation of hepatic phospholipid and bile acid homeostasis through SMAD3 activation by TGFβ. It has been implicated in human and experimental animal carcinogenesis. Preliminary in vitro research
Hexagonal leaflets (from alcohols) or prisms (from acetic acid) or white powder. (NTP, 1992)|Solid
Hexagonal leaflets (from alcohols) or prisms (from acetic acid) or white powder. (NTP, 1992)|Lithocholic acid is a monohydroxy-5beta-cholanic acid with a alpha-hydroxy substituent at position 3. It is a bile acid obtained from chenodeoxycholic acid by bacterial action. It has a role as a human metabolite, a mouse metabolite and a geroprotector. It is a bile acid, a monohydroxy-5beta-cholanic acid and a C24-steroid. It is a conjugate acid of a lithocholate.|A bile acid formed from chenodeoxycholate by bacterial action, usually conjugated with glycine or taurine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as cholagogue and choleretic.

Certificates

Basic Info

Product Name:

Lithocholic acid

Other Name:

Cholan-24-oic acid,3-hydroxy-,(3α,5β)-;5β-Cholan-24-oic acid,3α-hydroxy-;5β-Cholanic acid,3α-hydroxy-;(3α,5β)-3-Hydroxycholan-24-oic acid;3α-Hydroxycholanic acid;3α-Hydroxy-5β-cholanic acid;Lithocholic acid;3α-Hydroxy-5β-cholanoic acid;3α-Hydroxy-5β-cholan-24-oate;3-Hydroxycholan-24-oic acid;17β-(1-Methyl-3-carboxypropyl)etiocholan-3α-ol;3α-Hydroxy-5β-cholan-24-oic acid;NSC 683770;2360921-71-5

CAS No.:

434-13-9

Molecular Formula:

C24H40O3

InChIKeys:

InChIKey=SMEROWZSTRWXGI-HVATVPOCSA-N

Molecular Weight:

376.57

Exact Mass:

376.57

EC Number:

207-099-1

UNII:

5QU0I8393U

NSC Number:

683770

DSSTox ID:

DTXSID6020779

Color/Form:

HEXAGONAL LEAFLETS FROM ALC, PRISMS FROM ACETIC ACID

HScode:

29181998

Categories:

Nutrition Supplements

Characteristics

PSA:

57.5

XLogP3:

6.70

Appearance:

White to off-white Powder

Density:

1.1±0.1 g/cm3

Melting Point:

184-186 °C

Boiling Point:

511.0±23.0 °C at 760 mmHg

Flash Point:

9℃

Refractive Index:

35.5 ° (C=1, EtOH)

Water Solubility:

18.83ug/L(25 ºC)

Storage Conditions:

Refrigerator

Specific rotation:

D20 +33.7° (c = 1.5 in abs ethanol); D19 +23.3° (Wieland); D20 +32.1° (Fischer)

Collision Cross Section:

193.4 Å² [M+H-H2O]+ [CCS Type: DT, Method: single field calibrated with Agilent tune mix (Agilent)]|199.95 Å² [M-H]- [CCS Type: DT, Method: single field calibrated with Agilent tune mix (Agilent)]|200.33 Å² [M-H]- [CCS Type: DT, Method: stepped-field]|203.1 Å² [M-H]- [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|210.8 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]|198.9 Å² [M-H]- [CCS Type: DT, Method: single field calibrated]|191.6 Å² [M+H-H2O]+ [CCS Type: DT, Method: single field calibrated]|198.8 Å² [M+HCOO]- [CCS Type: DT, Method: single field calibrated]|204.1 Å² [M+K-H+HCOO]- [CCS Type: DT, Method: single field calibrated]|217.6 Å² [M+K-H+HCOO]- [CCS Type: DT, Method: single field calibrated]|197.9 Å² [M+Na-H+Cl]- [CCS Type: DT, Method: single field calibrated]|201.6 Å² [M+Na-H+HCOO]- [CCS Type: DT, Method: single field calibrated]|214.8 Å² [M+Na]+ [CCS Type: DT, Method: single field calibrated]|201.4 Å² [M-H]-

Experimental Properties:

CRYSTALS /ETHYL ESTER/|CRYSTALS /BENZYL ESTER/|CRYSTALS /ACETYLLITHOCHOLIC ACID/|FLAT NEEDLES FROM PENTANE /ACETYLLITHOCHOLIC ACID METHYL ESTER/|For more Other Experimental Properties (Complete) data for LITHOCHOLIC ACID (6 total), please visit the HSDB record page.

Air and Water Reactions:

Insoluble in water.

Reactive Group:

Acids, Carboxylic

See More Lithocholic acid Properties 

Hazard Identification

Classification of the substance or mixture

Not classified.

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	No symbol.
Signal word	No signal word
Hazard statement(s)	none
Prevention	none
Response	none
Storage	none
Disposal	none

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Lithocholic acid Safety Data Sheet 

Seller Information

Business Type:
Distributor

Main Products:
Nutrition supplement material,Pharmaceutical raw material,Chemical raw material

Location:
Changqing 5th Road, Jianghan District

Payment Terms:
TT against copy of documents

Average lead Time:
5

Total Annual Revenue:
$1 million-$2.5 million

Total Employees:
5-10

Year of Establishment:
2020

Wuhan Oner Biotech Co.,Ltd. located in the popular city of Wuhan, specilize in producing and developing pharmaceutical & its intermediates, Cosmetics Raw Material and Intermediate, food additive, Plant extracts,and in distributing the products of our own company. We serves our clients by supplying high-quality.These products are manufactured in ISO 9001 certified plants and have continuously been passing quality inspection by CIQ (China Entry & Exit Inspection and Quarantine Bureau),100% pass rate. Our company has professional staff who deal with chemical R&D and scientific management, and holds several sets of analyzing instruments with high efficiency and high sensitivity, such as HPLC, GC and Spectrophotometer. We have professional sales team, focus on quality and service, and we have achieved excellent performance over the years. Our company is committed to the development of international market , the products are mainly exported to many countries and regions, such as Europe, America, South-east Asia, the Middle East and Africa etc. With constant efforts and good service, We sincerely hope to establish long-term cooperation and common development with our customers.
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Lithocholic Acid High-Purity Secondary Bile Acid for Metabolic, Gut Microbiome, and FXR Signaling Research

Product Description

Seller Information

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