Nicotinamide Riboside Hydrogen Malate Premium NAD+ Precursor with Enhanced Stability and Bioavailability for Nutraceutical and Cellular Health

Product Name: Nicotinamide Riboside Hydrogen Malate
CAS Number: 2311252-06-7
Molecular Formula: C₁₅H₂₀N₂O₈
Molecular Weight: 356.33 g/mol
Appearance: White to off-white crystalline powder.

Nicotinamide Riboside Hydrogen Malate (CAS 2311252-06-7) is a high-purity, crystalline salt form of nicotinamide riboside (NR), featuring the hydrogen malate counterion to deliver superior physicochemical stability and improved aqueous solubility compared to other NR salts. As a highly bioavailable precursor to nicotinamide adenine dinucleotide (NAD+), this compound efficiently elevates intracellular NAD+ levels through the salvage pathway, thereby supporting critical cellular processes including mitochondrial function, DNA repair, sirtuin activation, and oxidative stress management. The hydrogen malate form offers enhanced resistance to moisture and thermal degradation, ensuring consistent performance in dietary supplement formulations, functional foods, and parenteral or oral dosage forms. It is extensively utilized in longevity research, metabolic health studies, neuroprotection investigations, and pharmaceutical development targeting age-related decline and metabolic disorders. Supplied as a white to off-white crystalline powder with stringent purity specifications, it meets rigorous quality standards for both research-grade investigations and large-scale nutraceutical manufacturing, providing formulators and researchers a reliable NAD+ boosting agent with documented stability profiles and reproducible bioavailability outcomes.

For regulatory compliance (e.g., USP, EP, JP), raw material Vidarabine must meet several rigorous standards:

• Assay (by HPLC): 98.0% – 102.0% on an anhydrous basis.

• Related Substances: Limits for specific impurities, notably Ara-Hx (NMT 2.0%), as well as any unspecified individual impurity (NMT 0.1%) and total impurities (NMT 2.0%).

• Residual Solvents: Must comply with ICH Q3C guidelines (Class 1 and 2 solvents limited or absent).

• Heavy Metals: NMT 20 ppm (typically lower for injectable grades).

• Water Content (Karl Fischer): NMT 6.0% (the material is hygroscopic to a degree).

• Microbial Limits: Total aerobic microbial count (TAMC) ≤ 1000 CFU/g, absence of S. aureus, P. aeruginosa, and Candida albicans.