Product Name: Nicotinamide Riboside Hydrogen Malate
CAS Number: 2311252-06-7
Molecular Formula: C₁₅H₂₀N₂O₈
Molecular Weight: 356.33 g/mol
Appearance: White to off-white crystalline powder.
Nicotinamide Riboside Hydrogen Malate (CAS 2311252-06-7) is a high-purity, crystalline salt form of nicotinamide riboside (NR), featuring the hydrogen malate counterion to deliver superior physicochemical stability and improved aqueous solubility compared to other NR salts. As a highly bioavailable precursor to nicotinamide adenine dinucleotide (NAD+), this compound efficiently elevates intracellular NAD+ levels through the salvage pathway, thereby supporting critical cellular processes including mitochondrial function, DNA repair, sirtuin activation, and oxidative stress management. The hydrogen malate form offers enhanced resistance to moisture and thermal degradation, ensuring consistent performance in dietary supplement formulations, functional foods, and parenteral or oral dosage forms. It is extensively utilized in longevity research, metabolic health studies, neuroprotection investigations, and pharmaceutical development targeting age-related decline and metabolic disorders. Supplied as a white to off-white crystalline powder with stringent purity specifications, it meets rigorous quality standards for both research-grade investigations and large-scale nutraceutical manufacturing, providing formulators and researchers a reliable NAD+ boosting agent with documented stability profiles and reproducible bioavailability outcomes.
ITEMS | STANDARDS | RESULTS |
Description | White to almost white powder | White powder |
UV absorbance ratio | A250/A260 A280/A260 | 0.41-0.49 2.03-2.71 | 0.45 2.14 |
PH | 2.0-4.0 | 2.68 |
Loss on drying | ≤5.0% | 2.64% |
Assay (UV) | ≥98.0% | 99.17% |
Transmittance | ≥98.5% | 99.1% |
Heavy metals | ≤10ppm | ＜10ppm |
Purity (HPLC) | ≥98.0% | 99.6% |
Conclusion | It complies to the standard |
For regulatory compliance (e.g., USP, EP, JP), raw material Vidarabine must meet several rigorous standards:
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Assay (by HPLC): 98.0% – 102.0% on an anhydrous basis.
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Related Substances: Limits for specific impurities, notably Ara-Hx (NMT 2.0%), as well as any unspecified individual impurity (NMT 0.1%) and total impurities (NMT 2.0%).
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Residual Solvents: Must comply with ICH Q3C guidelines (Class 1 and 2 solvents limited or absent).
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Heavy Metals: NMT 20 ppm (typically lower for injectable grades).
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Water Content (Karl Fischer): NMT 6.0% (the material is hygroscopic to a degree).
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Microbial Limits: Total aerobic microbial count (TAMC) ≤ 1000 CFU/g, absence of S. aureus, P. aeruginosa, and Candida albicans.
As a high-purity pharmaceutical intermediate, L-Tyrosine Ethyl Ester Hydrochloride is predominantly utilized in the chemical synthesis of bioactive peptides, dopamine analogs, and melanin precursors. Its excellent solubility profile makes it an ideal chiral building block for asymmetric synthesis and a critical substrate in enzymatic reactions. Available in purity grades of ≥98% (HPLC), it meets stringent requirements for R&D and cGMP manufacturing processes. Reliable supply ensures batch-to-batch consistency for long-term project scalability.
Vidarabine is classified as a potential reproductive hazard and an irritant. Safety Data Sheets (SDS) mandate the following:
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Hazard Statements (H360): May damage fertility or the unborn child (Category 1B).
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Precautionary Measures: Use fume hoods and wear impermeable gloves (e.g., nitrile), lab coats, and safety goggles. Avoid generating airborne dust.
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First Aid: In case of skin contact, wash immediately with copious soap and water. If inhaled, move to fresh air.
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Storage: Store in tightly sealed, light-resistant containers at 2°C to 8°C (refrigerated) for long-term stability. Avoid freezing.
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While superseded by newer nucleoside analogs (Acyclovir, Ganciclovir) for systemic use due to better bioavailability and lower toxicity, Vidarabine retains niche value. Its primary current application is ophthalmic ointment (3%) . Pharmacokinetically, the raw material has poor oral bioavailability (<10%) and is rapidly deaminated in the gastrointestinal tract, necessitating parenteral or topical administration.
Vidarabine API is a well-characterized, stable crystalline nucleoside analog. While its systemic use has declined, it remains a critical raw material for topical antiviral ophthalmic preparations, particularly where resistance to other agents occurs. Manufacturers must strictly control impurities (especially Ara-Hx) and water content to ensure final drug product efficacy.
