In the field of modern organic synthesis and polypeptide chemistry, Fmoc- protected amino acids (9- fluorene methoxycarbonyl protected amino acids) have become an indispensable core building block in solid-phase polypeptide synthesis (SPPS) because of their excellent orthogonal protection performance and mild deprotection conditions. This strategy was developed and optimized by Robert Bruce Merrifield, and now it is widely used in frontier research directions such as drug research and development, biological probe design and functional material development.
Fmoc amino acids application:
Fmoc group can effectively prevent the occurrence of side reactions in the synthesis process by forming stable covalent bonds with amino acid α-amino, and can be efficiently removed under weak alkaline conditions (such as 20% piperidine /DMF) without affecting side chain protecting groups or other sensitive functional groups. This orthogonal protection mechanism significantly improves the yield and purity of long-chain polypeptide synthesis, and is especially suitable for sequence construction with complex modifications or unnatural amino acids.
Omizzur Fmoc-amino acids & Unnatural amino acids in Peptide Synthesis:
| Name | CAS | Name | CAS |
| Fmoc-Ala-OH | 35661-39-3 | Fmoc-Arg(Pbf)-OH | 154445-77-9 |
| Fmoc-Asn(Trt)-OH | 132388-59-1 | Fmoc-Asp(OtBu)-OH | 71989-14-5 |
| Fmoc-Cys(Trt)-OH | 103213-32-7 | Fmoc-Gln(Trt)-OH | 132327-80-1 |
| Fmoc-Glu(OtBu)-OH | 71989-18-9 | Fmoc-Gly-OH | 29022-11-5 |
| Fmoc-His(Trt)-OH | 109425-51-6 | Fmoc-Ile-OH | 71989-23-6 |
| Fmoc-Leu-OH | 35661-60-0 | Fmoc-Lys(Boc)-OH | 71989-26-9 |
| Fmoc-Met-OH | 71989-28-1 | Fmoc-Phe-OH | 35661-40-6 |
| Fmoc-Pro-OH | 71989-31-6 | Fmoc-Ser(tBu)-OH | 71989-33-8 |
| Fmoc-Thr(tBu)-OH | 71989-35-0 | Fmoc-Trp(Boc)-OH | 143824-78-6 |
| Fmoc-Tyr(tBu)-OH | 71989-38-3 | Fmoc-Val-OH | 68858-20-8 |
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| Unnatural amino acids: |
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| Fmoc-1-Nal-OH | 96402-49-2 | Fmoc-Aib-OH | 94744-50-0 |
| Fmoc-N-Me-Asn(Trt)-OH | 941296-80-6 | Fmoc-L-Thz(Me2)-OH | 873842-06-9 |
| Fmoc-L-Isovaline | 857478-30-9 | Boc-Lys(Fmoc)-OH | 84624-27-1 |
| Fmoc-Thz-OH | 423719-54-4 | Fmoc-D-2-Methylphe | 352351-63-4 |
| Fmoc-ThpGly-OH | 285996-72-7 | Fmoc-L-Pen(Trt)-OH | 201531-88-6 |
| Fmoc-Pra-OH | 198561-07-8 | Fmoc-Trp(7-Me)-OH | 1808268-53-2 |
| Fmoc-Phg-Phg-OH | 1613187-52-2 | Fmoc-Lys(AC)-OH | 159766-56-0 |
| Fmoc-D-Tyr(Bzl)-OH | 138775-48-1 | Fmoc-α-methyl-L-Phe | 135944-05-7 |
| Fmoc-β-Ala-Tyr-OH | 1349674-10-7 | Fmoc-Tyr-Tyr-OH | 1269665-49-7 |
| Fmoc-α-methyl-L-2-Fluorophe | 1172127-44-4 | Fmoc-L-2-Naphthylalanine | 112883-43-9 |
| Fmoc-D-Cys((CH2)3COOtBu)-OH | 102971-73-3 | Fmoc-Ser(O-β-D-Glc)-OH | N/A |
* For more demand about fmoc amino acids and unnatural amino acids, pls get in touch with Omizzur peptide teams.
In practical scientific research, the purity, chiral retention and solubility of Fmoc- protected amino acids directly affect the quality of the final product. Omizzur Peptide has been focusing on the preparation and characterization of high-purity Fmoc- amino acids for a long time. Its products cover standard protein-derived amino acids and a variety of unnatural derivatives, and strictly follow the relevant guiding principles of ICH Q7 and USP to ensure batch consistency.
Shipping: Deliver to worldwide by Fedex / DHL for free shipping (A certain amount of order should be met)
Information attached with the products: COA / HPLC / MS analysis report.
Omizzur biotech is committed to the synthesis of various amino acid derivatives and peptides. At present, there are more than 1,000 kinds of amino acid products and more than 200 kinds of peptide products available in stock. In addition, Omizzur also provides customized synthesis of peptides, which can be used for scientific research. A large order will have discount.
