Salmon Calcitonin Peptide API & Impurities for Research 99% Purity

Salmon Calcitonin API and Impurities for Research 

Salmon calcitonin is a single-chain polypeptide hormone composed of 32 amino acids, which is mainly used in scientific research experiments.

Structural characteristics: Peptide hormone consisting of 32 amino acid residues, with intramolecular disulfide bond cyclization structure at the N-terminal, amidation modification at the C-terminal, no additional lateral chain modification and no cross-linking structure outside cyclization, belongs to the calcitonin family.

The core sequence of salmon calcitonin is Cys-Ser-Asn-Leu-Ser-Thr-Cys-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Gly-Thr-Pro.

Origin and synthesis of salmon calcitonin:

It naturally exists in the parathyroid cells of salmon. At present, Omizzur uses all chemical synthesis products (solid phase synthesis method), the purity is ≥99%(HPLC detection), and the active unit is "IU" (1 IU≈0.2 μg synthetic salmon calcitonin).

Physical and chemical properties of salmon calcitonin:

white powder, easily soluble in water (10 mg/mL), slightly soluble in e thanol and insoluble in ether; The stability is the best at pH 3.0-6.0, and it is easy to degrade when heated (> 60℃) or under strong acid and alkali conditions. Sensitive to protease, dosage form modification (such as nasal spray and sustained-release microspheres) is needed to improve bioavailability.

Omizzur Peptide Lab

Omizzur peptide is supplying salmon calcitonin and various related peptide impurities, which are mainly used in scientific research and experiments. Most products are in stock. If there are special requirements, they need to be customized. The customization is about 2-3 weeks. Omizzur provides a complete analysis report. (HPLC,MS,COA)

Omizzur Peptide Synthesis Lists

***For more peptide catalog pls make inquiry here or get in touch with Omizzur lab:  service(at)omizzur.com 

Research Progress of Salmon Calcitonin
After salmon calcitonin was isolated and identified from fish ultimobranchial body, its 32nd amino acid sequence, disulfide bond and amidation key structure were identified, and it became a benchmark polypeptide in the study of calcitonin family structure-activity relationship.

Early studies confirmed that its biological activity was much higher than that of mammalian calcitonin, which laid the foundation for the first choice of calcitonin polypeptide drugs in clinic. It is widely used in the clinical intervention of postmenopausal and senile osteoporosis, osteitis deformans, hypercalcemia of malignant tumor and intractable bone pain of bone metastasis cancer.

Salmon calcitonin is often used as a tool peptide in the research field for bone metabolism signal pathway, osteoclast differentiation regulation, GPCR receptor conformation and ligand binding mechanism; In terms of preparation research and development, various dosage forms such as nasal spray and microsphere sustained-release preparation have been developed one after another to improve the convenience of administration and bioavailability; At the same time, based on its core structure, the peptide analogues were modified, and the active skeleton was retained and the stability and pharmacokinetic characteristics were optimized, which provided an important template for the development of new anti-osteoporosis peptide drugs.

Omizzur Salmon Calcitonin Photos For Real:

How does Omizzur control the purity of API peptide?

The purity of Omizzur polypeptide API is mainly ensured by strict quality control procedures, including raw material screening, process optimization and analysis and detection.

In the process of synthesis, we will monitor the impurities such as missing peptides and inserted peptides, and use high performance liquid chromatography (HPLC) to separate and quantify them.

In addition, Omizzur will also compare synthetic reference materials to ensure that hidden impurities such as optical isomers can also be accurately identified and controlled.

Stability test is also the key, because peptides are easily affected by temperature and humidity, so it is necessary to monitor the degradation risk throughout.

We provide quality inspection report (COA),MS and HPLC charts for each batch of api peptides, and are responsible for the quality of this batch of peptides.

Shipping: Deliver to worldwide by Fedex / DHL / By air

Information attached with the products: HPLC/MS/COA analysis report.