Epitalon 99% High Purity Tetrapeptide Multiple Sizes: 10 mg / 50 mg per Vial

Product Description – The Science of Epitalon in Topical Skin Research
Epitalon is a synthetic tetrapeptide with the amino acid sequence L‑Alanyl‑L‑α‑glutamyl‑L‑α‑aspartylglycine (Ala‑Glu‑Asp‑Gly, AEDG) [10†L7-L8]. It was designed based on the composition of epithalamin, a naturally occurring polypeptide complex isolated from the bovine pineal gland, and has been the subject of extensive laboratory research since the 1990s [12†L15-L19][14†L5-L9].
For formulators and researchers working in the field of dermal aging, Epitalon offers a unique activity profile that includes telomerase modulation, antioxidant enhancement, influence on neuroendocrine pathways, and potential epigenetic regulation of chromatin structure [7†L21-L42][8†L41-L45]. The following sections examine the core properties that form the scientific basis for its use in topical skin research.
Telomerase Activity and Telomere Biology in Dermal Fibroblasts
One of the most well‑documented effects of Epitalon is its ability to induce telomerase activity, with quantitative assays showing upregulation of hTERT (the catalytic subunit of telomerase reverse transcriptase) [6†L22-L24]. In human skin fibroblasts, telomeres shorten with each cell division. When they reach a critically short length, the cells enter replicative senescence — an irreversible growth arrest accompanied by the secretion of inflammatory factors and ECM‑degrading enzymes that accelerate the ageing of surrounding tissue [11†L22-L33].
Research using the TRAP (telomeric repeat amplification protocol) assay has demonstrated that Epitalon increases telomerase activity in human fibroblast cultures at concentrations within the 0.1‑1 µg/mL range. After prolonged treatment (6‑12 weeks), mean telomere restriction fragment (TRF) length has been observed to increase in passage‑matched comparisons [11†L34-L42]. In a 2025 study, Epitalon induced dose‑dependent telomere length extension in normal epithelial and fibroblast cells via the upregulation of hTERT mRNA expression [9†L24-L33]. By supporting telomere maintenance, the peptide provides a unique research tool for preserving fibroblast replicative capacity and reducing the burden of senescent cells in the dermis.
Fibroblast Senescence and Extracellular Matrix (ECM) Modulation
Senescent fibroblasts exhibit the senescence‑associated secretory phenotype (SASP) , which includes elevated levels of IL‑6, IL‑8, MMP‑1, MMP‑3, and PAI‑1, along with reduced TIMP expression. This profile accelerates ECM degradation, impairs wound healing, and creates a pro‑inflammatory microenvironment that is considered a mechanistic driver of the ageing dermis [11†L28-L33]. Through its influence on telomere biology and associated senescence pathways, Epitalon has been studied for its potential to reduce the accumulation of senescent cells and modulate the SASP, thereby supporting a more regenerative dermal environment [7†L34-L38].
In vitro studies on aging skin fibroblasts have also reported that Epitalon inhibits the synthesis of the MMP‑9 protein, a matrix metalloproteinase involved in collagen and elastin breakdown. In senescence‑accelerated mice (SAMP‑1), treatment with Epitalon was associated with reduced levels of DNA damage [10†L11-L13]. By helping to preserve the structural matrix of the skin, this ECM‑modulating activity makes Epitalon a candidate for formulations targeting loss of firmness and age‑related dermal deterioration.
Antioxidant Defense and Cytoprotection
Oxidative stress is a key driver of both intrinsic (chronological) and extrinsic (photo‑induced) skin aging. Cellular antioxidants, including superoxide dismutase (SOD) , catalase, and glutathione peroxidase, decline with age, leading to an accumulation of reactive oxygen species (ROS) and subsequent damage to lipids, proteins, and DNA.
Research in aging models indicates that Epitalon can enhance the activity of key antioxidant enzymes (SOD, glutathione peroxidase), reducing oxidative damage at the cellular level [8†L21-L24]. In vitro studies have shown that the tetrapeptide also protects against high glucose‑induced oxidative stress, and in human retinal pigment epithelial cells, it has been shown to support cellular viability under adverse conditions — a protective effect that may translate to improving the resistance of skin cells to environmental aggressors [8†L24-L26]. By mitigating free‑radical damage, Epitalon helps preserve collagen integrity, reduces the likelihood of premature cellular dysfunction, and supports overall skin health.
Gene Expression Modulation and Epigenetic Pathways
Emerging evidence suggests that Epitalon may act as a modulator of gene expression at the epigenetic level. Molecular modeling and cell studies indicate that the tetrapeptide can bind to specific histones (H1/3, H1/6) and DNA promoter regions, thereby influencing chromatin structure and the transcription of genes associated with cellular repair, differentiation, and survival [8†L27-L32].
This gene‑regulatory activity may explain the peptide's broad effects on multiple biological pathways and its ability to promote cell specialization and tissue‑specific development in laboratory models [8†L37-L40]. It also provides a mechanistic foundation for the observed upregulation of telomerase and the enhanced expression of antioxidant enzymes. For formulators, this suggests that Epitalon is not a single‑pathway peptide, but rather a multi‑functional molecule that works at the level of the cell genome to support resilience, repair, and regenerative capacity [8†L43-L46].

1. Ultra-High Purity
Each batch is synthesized and purified to >99% purity (HPLC), ensuring reliable and reproducible results in sensitive experiments.
2.Accurate Dosing & Consistency
Our peptides are precisely weighed and vacuum-sealed under sterile conditions. Batch-to-batch consistency is rigorously maintained.
3.Endotoxin-Free & Sterile Processing
Manufactured in a cleanroom environment, our peptides are free from endotoxins, microbial contamination, and other impurities that could interfere with cell-based or in vivo studies.

Sales manager:  Eira

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1. Advanced Manufacturing Capabilities

Cutting-Edge Facilities: High-precision equipment ensuring purity and bioactivity.

Scalable Production: From milligram-scale research peptides to multi-kilogram industrial batches.

2. Innovation & Customer Commitment

Reliable Supply Chain: Competitive pricing & timely global delivery.

Global Reach: Trusted by researchers, pharmaceutical firms & industrial clients worldwide.

Q1: May I get one sample before placing order?
Re: Yes, Sample are available. For normal products, samples are for free and you just need to bear the freight; For those high value products, you just need to freight and certain product cost. When we both cooperate for some times or when you are our VIP customer, free sample will be offered when you need.
Q2: Which payment is available for your company?
Re: T/T, PayPal,bank transfer etc. You can choose the one which is convenient for you.
Q3: How and when can I get my goods after payment?
Re: For small quantity products, they will be delivered to you by international courier(DHL, FedEx, TNT etc.) or by air. Usually it will cost 5-7days that you can get the goods after delivery.For large quantity products, shipping by see is worthwhile.It will cost 15 to 30 days to come to your destination port, which depends on where the port is.
Q4: Is there any possible to use my appointed label or package?
Re: Yes. If needed, we'd lik.

1. Expertise in Peptide Synthesis
Extensive Experience: 7 Years of expertise in synthetic peptide development.
Skilled Team: Experts in solid-phase and liquid-phase synthesis.
2. Advanced Manufacturing Capabilities
Cutting-Edge Facilities: High-precision equipment ensuring purity and bioactivity.
Scalable Production: From milligram-scale research peptides to multi-kilogram industrial batches.
3. Innovation & Customer Commitment
Reliable Supply Chain: Competitive pricing & timely global delivery.
Global Reach: Trusted by researchers, pharmaceutical firms & industrial clients worldwide.
4. Ultra-High Purity
Each batch is synthesized and purified to >99% purity (HPLC), ensuring reliable and reproducible results in sensitive experiments.
5.Accurate Dosing & Consistency
Our peptides are precisely weighed and vacuum-sealed under sterile conditions. Batch-to-batch consistency is rigorously maintained.
6.Endotoxin-Free & Sterile Processing
Manufactured in a cleanroom environment, our peptides are free from endotoxins, microbial contamination, and other impurities that could interfere with cell-based or in vivo studies.

Why Choose Our Peptides?

• Quality Assured: Sourced from trusted manufacturers with reliable global distribution, ensuring consistency and potency .
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• Why Partner with us?

  
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  Manufactured in GMP-certified facilities with full traceability and regulatory-aligned documentation.
  

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  Available in multiple formats. Consistent lead times with flexible production capacity.
  

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  Factory-direct pricing with volume discounts; stable supply chain to meet your market demand.
  

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  Full documentation and formulation guidance.