API Sarolaner

Sarolaner More Info

Sarolaner is an active pharmaceutical ingredient belonging to the isoxazoline class of parasiticides. It is specifically developed as an ectoparasiticide for use in veterinary medicine, primarily targeting dogs.

General Description

Sarolaner is a drug with activity against adult fleas and certain tick species. These parasites can cause discomfort and skin irritation to pets, while ticks can transmit serious diseases and may pose health risks to household members. The product is formulated as an oral chewable tablet designed for easy administration to dogs according to their body weight.

Key Features

Sarolaner demonstrates superior efficacy compared to other isoxazoline molecules. It requires less active ingredient to achieve the same level of effectiveness against target parasites. The compound shows high palatability, making it an appealing option for pet owners and pets alike. It is safe for all canine breeds, including puppies as young as 8 weeks old and weighing 1.25 kg or more.

Target Parasites

The medication is active against adult fleas, including Ctenocephalides felis and Ctenocephalides canis. It also targets several tick species such as Dermacentor reticulatus, Ixodes hexagonus, Ixodes ricinus, and Rhipicephalus sanguineus. Additionally, it provides effectiveness against mites including Demodex canis, Otodectes cynotis, and Sarcoptes scabiei.

Administration and Dosage

Each tablet is formulated to provide a minimum sarolaner dosage of 2 mg/kg of body weight. The chewable tablets come in various strengths, including 5, 10, 20, 40, 80, or 120 mg options, allowing for precise dosing based on the dog's weight. Treatment is administered orally on a monthly basis to provide persistent protection.

Product Information

Chemical Name: 1-(5'-(5S)-5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'-H-spiro(azetidine-3,1'-(2)benzofuran)-1-yl)-2-(methylsulfonyl)ethanone

CAS Registry Number: 1398609-39-6

Molecular Formula: C23H18Cl2F4N2O5S

Molecular Weight: 581.36 g/mol

The product is manufactured by Zoetis and is available under the brand name Simparica. It is a veterinary-use-only medication and requires a prescription from a licensed veterinarian.

Safety and Storage

Sarolaner belongs to the isoxazoline class of drugs. The product should be stored properly to maintain efficacy. It provides protection against fleas and ticks for at least 4 weeks after administration.

Brand Products

The primary brand offering sarolaner is Simparica, which comes in flavored chewable tablets. There is also Simparica TRIO, which contains sarolaner combined with moxidectin and pyrantel for broader parasite control.

Conclusion

Sarolaner represents an effective and convenient solution for controlling external parasites in dogs. Its oral chewable tablet form, combined with high palatability and broad-spectrum activity, makes it a valuable choice for veterinary practitioners and pet owners seeking reliable parasite protection.