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API Nafamostat mesylate

Name: API Nafamostat mesylate
Brand: Hyper Chem
SKU: pr2606081749
Price: 35000 USD
Availability: InStock

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CAS No.:

82956-11-4

Grade:

Pharmaceutical Grade

Content:

99%

Port:

shanghai

Brand:

Hyper Chem

Packaging:

20kg/Drum 25kg/Drum

Price valid (until):

2026-07-08

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Hangzhou Hyper Chemicals Limited

Company Type:

Trader

Location:

China

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Main Products:

Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

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Product Description
Seller Information

Description

Name	Nafamostat mesylate
CAS number	82956-11-4
Description	Nafamostat (FUT-175) is a potent, broad-spectrum synthetic serine protease inhibitor with well-documented in vitro and in vivo bioactivity. It exhibits nanomolar inhibitory potency against key proteases including trypsin, thrombin, plasmin, kallikrein, and complement-related enzymes, with reported IC₅₀ values typically in the 1–100 nM range depending on the target. In vitro, nafamostat effectively suppresses coagulation and fibrinolysis pathways and has demonstrated strong antiviral activity by inhibiting TMPRSS2-mediated viral entry, including SARS-CoV-2, with sub-micromolar EC₅₀ values. In vivo studies show that nafamostat exerts anticoagulant and anti-inflammatory effects, reducing cytokine release, vascular permeability, and organ damage in models of acute pancreatitis, sepsis, and disseminated intravascular coagulation (DIC). Its rapid onset and short half-life make it particularly suitable for continuous infusion in clinical settings. These properties position nafamostat as a valuable research tool and therapeutic candidate for coagulation disorders, inflammatory diseases, and viral infections.
Related CAS #	81525-10-2 (free base) 82956-11-4 (mesylate) 80251-32-7 (HCl)
Synonym	Nafamostat mesylate; nafamostat mesilate; FUT-175; FUT 175; FUT175.
Appearance	Solid powder
Quality Standard	USP, EP, BP, CP
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
Shelf Life	>2 years if stored properly
Sample package	Aluminium foil bag
Commercial package	Aluminium Tin, Fiber drum
Origin	China

Nafamostat More Info

Overview

Nafamostat is a synthetic broad-spectrum serine protease inhibitor originally developed in Japan. This pharmaceutical compound is classified as a small molecule innovative drug under the chemistry category. Nafamostat mesylate is the most common form of this compound available commercially.

Chemical Properties

The systematic chemical name for Nafamostat is 4-[(aminimino)methyl]amino]-6-(anilinimino)methyl)-2-naphthalenyl ester-benzoic acid, dimethanesulfonate. The molecular formula is C₁₉H₁₇N₅O₂ • 2CH₃SO₃H with a molecular weight of 539.6 g/mol. The CAS number for this compound is 82956-11-4. The compound appears as a white crystalline solid with a purity of ≥98%.

Alternative Names and Brand Names

Nafamostat is known by various trade names including Futhan, FUT-175, FUT175, Naotamin, Opsun, Coahibitor, and Nafamastat. The compound also carries the designation CKD-314 in some pharmaceutical databases.

Mechanism of Action

Nafamostat functions as a potent serine protease inhibitor that targets multiple proteolytic enzymes including trypsin, thrombin, factor Xa, and plasmin. These enzymes play crucial roles in coagulation, fibrinolysis, and inflammatory responses. The compound demonstrates inhibitory effects with K_i values of 15 nM for trypsin, 95.3 pM for tryptase, and 0.84 μM for thrombin. Additionally, Nafamostat exhibits anti-inflammatory properties and has been shown to suppress lipopolysaccharide-induced nitric oxide generation.

Pharmacokinetics

The compound undergoes metabolism primarily in the liver, producing metabolites such as p-guanidinobenzoic acid (PGBA) and 6-amidino-2-naphthol (AN). These metabolites are primarily eliminated through renal excretion. The metabolic products function as inactive protease inhibitors.

Therapeutic Applications

Nafamostat has been utilized clinically for the treatment of acute pancreatitis and disseminated intravascular coagulation (DIC). The compound has demonstrated efficacy in preventing thrombosis formation during extracorporeal circulation and shows neuroprotective effects in ischemic brain injury models. Research has also indicated potential antiviral properties and applications in respiratory conditions. The drug has been used in hemodialysis settings to prevent fibrinogen decomposition.

Product Form and Supply

Nafamostat mesylate is supplied as a lyophilized powder. The product maintains stability for a minimum of 2 years when stored at -20°C. The compound is soluble in DMSO at approximately 50 mg/ml. When diluted in water buffers, the solubility is approximately 0.5 mg/ml.

Safety and Precautions

The compound has been approved for use in Japan and South Korea where it has been administered clinically since the 1980s. As a protease inhibitor, the compound may affect multiple enzyme systems including coagulation systems, kinin systems, complement systems, and protease-activated receptors.

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Basic Info

Product Name:

Nafamostat mesylate

Other Name:

Benzoic acid,4-[(aminoiminomethyl)amino]-,6-(aminoiminomethyl)-2-naphthalenyl ester,methanesulfonate (1:2);Benzoic acid,4-[(aminoiminomethyl)amino]-,6-(aminoiminomethyl)-2-naphthalenyl ester,dimethanesulfonate;FUT 175;Nafamostat mesylate;Nafamostat mesilate;6-Amidino-2-naphthyl p-guanidinobenzoate;Futhan;Nafamostat dimethanesulfonate;Nafamastat mesylate;Coahibitor

CAS No.:

82956-11-4

Molecular Formula:

C19H17N5O2.2CH4O3S

InChIKeys:

InChIKey=ZESSXQLDESEKGC-UHFFFAOYSA-N

Molecular Weight:

539.58

Exact Mass:

539.114

EC Number:

1806241-263-5

HScode:

29252900

Categories:

Inhibitors

Characteristics

PSA:

266

Melting Point:

217-220 °C

Boiling Point:

637.2°C at 760 mmHg

Flash Point:

339.1ºC

Storage Conditions:

room temp

Toxicity:

Oral-rat LD50: 3050 mg/kg; Oral-Mouse LD50: 4600 mg/kg

Flammability characteristics:

Flammable; burning produces toxic nitrogen oxides and sulfur oxide fumes

See More Nafamostat mesylate Properties 

Hazard Identification

Classification of the substance or mixture

Reproductive toxicity, Category 2

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H361 Suspected of damaging fertility or the unborn child
Prevention	P203 Obtain, read and follow all safety instructions before use. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response	P318 IF exposed or concerned, get medical advice.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Nafamostat mesylate Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

Location:
Rm. 803, Tower 4, LOFT49 Creative City Pioneer Zone, No.88 Jiru Rd. Gongshu Dist., Hangzhou, 310015 ZJ, China

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$5 million-$10 million

Total Employees:
11-50

Year of Establishment:
2013

Certifications:
Certification Report by Bureau Veritas

About HyperChem

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to meet the needs of a diverse range of pharmaceutical cosmetics ingredients and nootropic supplements companies worldwide.

Our Competitiveness

One-stop supply

Wide Range Of products including pharmaceutical, Cosmetic Ingredients and nootropic supplements

Among all the pharmaceuticals,

90% of them with GMP certificates,

85% of them with DMF files and

50% of them passed FDA approval,

30% get CEP certificate

20% are new R&D products.

Custom Repackaging Service

We can efficiently repackage your material into sample sizes, custom batch-specific sizes, or semi-bulk package sizes according to your specifications. And ensures the product is packaged in a quality-controlled environment and will maintain its integrity throughout every stage of the process.

Quality Control/Quality Assurance

HyperChem is committed to delivering on its promises of top-quality products with verified quality data.

All materials are vigorously inspected by the factory and/or outsourced analytical laboratories to ensure each and every lot meets or exceeds our reference standards.

Trade assurance service with 100% payment protection, It is best achieved by delivering products and services 100% right the first time, on time, every time.

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Beyond Expectation.

We have exclusive partnerships with research and production facilities across the country and we offer varied pharmaceutical services in the most cost-efficient way. The production facilities are GMP, WHO-GMP, EU GMP and US FDA approved and are backed by strong regulatory support such as Dossier, DMF, Tech Pack and relevant Stability studies for regulatory filings.
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