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Pharmaceutical Grade 99% Cetirizine dihydrochloride/Cetirizine HCl CAS:83881-52-1 buy - large image1

Pharmaceutical Grade 99% Cetirizine dihydrochloride/Cetirizine HCl CAS:83881-52-1 buy - image1

Pharmaceutical Grade 99% Cetirizine dihydrochloride/Cetirizine HCl CAS:83881-52-1 buy - image2

Pharmaceutical Grade 99% Cetirizine dihydrochloride/Cetirizine HCl CAS:83881-52-1 buy - image3

Pharmaceutical Grade 99% Cetirizine dihydrochloride/Cetirizine HCl CAS:83881-52-1 buy - image4

Pharmaceutical Grade 99% Cetirizine dihydrochloride/Cetirizine HCl CAS:83881-52-1

Name: Pharmaceutical Grade 99% Cetirizine dihydrochloride/Cetirizine HCl CAS:83881-52-1
Brand: HyperChem
SKU: pr2504091332
Price: 160 USD
Availability: InStock

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CAS No.:

83881-51-0

Grade:

Pharmaceutical Grade

Content:

99.9%

Port:

Hangzhou

Brand:

HyperChem

Packaging:

1g/bag, 20g/bag, 50g/bags or other quantities

Price valid (until):

2025-05-31

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Hangzhou Hyper Chemicals Limited

Company Type:

Trader

Location:

China

Qualification:

Main Products:

Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

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Product Description
Seller Information
Inquiry History

Description

Name	L-Carnitine
CAS number	541-15-1
Synonym	L-Carnitine Base
Related APIs #	L-Lysine L-Citrulline L-Ornithine L-Histidine L-Norvaline Arginine Alpha-Ketoglutarate (AAKG) Arginine Hydrochloride Arginine Ethyl Ester Arginine Silicate Arginine Ketoisocaproate L-Glutamine L-Tyrosine L-Leucine L-Isoleucine L-Valine Beta-Alanine Taurine N-Acetyl-L-Carnitine Glycine Propionyl-L-Carnitine L-Carnitine L-Tartrate
Description	Introduction L-Carnitine is a naturally occurring amino acid derivative that plays a critical role in energy metabolism by facilitating the transport of fatty acids into mitochondria for oxidation. It is synthesized in the liver, kidneys, and brain from the amino acids lysine and methionine, with the assistance of vitamin C, iron, niacin, and vitamin B6. While the body produces adequate amounts of L-carnitine under normal conditions, dietary sources such as red meat, dairy products, and certain fish also contribute to its levels. In recent decades, L-carnitine has gained popularity as a dietary supplement, particularly among athletes and individuals seeking to enhance weight loss or improve exercise performance. This article explores its chemical mechanism, physiological roles, common uses, and safety considerations. Chemical Structure and Biosynthesis L-Carnitine (β-hydroxy-γ-N-trimethylaminobutyric acid) is a quaternary ammonium compound with the molecular formula C₇H₁₅NO₃. Its structure consists of a hydroxyl group (-OH), a carboxyl group (-COOH), and a trimethylammonium group, which together enable its function as a molecular shuttle. The biologically active form is the L-isomer; the D-isomer is inactive and not utilized by the body. Biosynthesis occurs in a multi-step process: Lysine methylation: Lysine is methylated using S-adenosylmethionine (SAMe) to form ε-trimethyllysine. Hydroxylation and cleavage: Enzymatic reactions convert trimethyllysine into γ-butyrobetaine, which is then hydroxylated to form L-carnitine in the liver and kidneys. This process requires cofactors such as iron (Fe²⁺), ascorbic acid (vitamin C), and α-ketoglutarate. Mechanism of Action L-Carnitine's primary role is to transport long-chain fatty acids (LCFAs) across the inner mitochondrial membrane, a critical step in energy production. The process involves the following steps: Activation of Fatty Acids: LCFAs are converted to fatty acyl-CoA esters in the cytosol. Translocation via the Carnitine Shuttle: Carnitine palmitoyltransferase I (CPT1), located on the outer mitochondrial membrane, transfers the acyl group from CoA to carnitine, forming acyl-carnitine. Acyl-carnitine is shuttled across the inner mitochondrial membrane by a carnitine-acylcarnitine translocase. Carnitine palmitoyltransferase II (CPT2) inside the mitochondrial matrix regenerates acyl-CoA and releases free carnitine for recycling. This transport mechanism enables fatty acids to undergo β-oxidation, producing ATP via the citric acid cycle and oxidative phosphorylation. L-Carnitine also modulates the mitochondrial acetyl-CoA/CoA ratio by exporting excess acetyl groups as acetyl-L-carnitine, ensuring optimal enzyme activity in energy metabolism. Physiological Roles Energy Production: By promoting fatty acid oxidation, L-carnitine helps spare glycogen stores during prolonged exercise and supports endurance. Detoxification: It removes toxic acyl groups generated from metabolism or drug metabolism (e.g., valproate toxicity). Cellular Protection: L-Carnitine acts as an antioxidant, scavenging free radicals and reducing oxidative stress. Cardiovascular Health: It improves cardiac energetics by enhancing fatty acid utilization in heart muscle and may reduce symptoms of ischemia. Sperm Motility: High concentrations of L-carnitine in seminal fluid are linked to improved sperm function. Supplementation: Uses and Dosage L-Carnitine is marketed in several forms, including L-carnitine tartrate, acetyl-L-carnitine (ALCAR), and propionyl-L-carnitine (PLC), each tailored for specific applications: Exercise Performance: Dose: 2–3 g/day of L-carnitine tartrate. Rationale: Reduces muscle soreness, enhances recovery, and may delay fatigue by optimizing fat metabolism. Weight Loss: Dose: 500 mg–2 g/day. Note: Evidence is mixed, but it may aid fat loss when combined with exercise and calorie restriction. Heart Health: Dose: 1–3 g/day of PLC for angina or heart failure. Mechanism: Improves blood flow and reduces cardiac workload. Cognitive Function: ALCAR (1.5–3 g/day) crosses the blood-brain barrier, potentially alleviating age-related cognitive decline. Medical Conditions: Used to treat primary or secondary carnitine deficiencies, often at doses of 50–200 mg/kg/day. Safety and Side Effects L-Carnitine is generally safe at recommended doses. However, excessive intake (>5 g/day) may cause: Gastrointestinal distress: Nausea, diarrhea, or abdominal cramps. Fishy body odor: Due to bacterial metabolism of excess trimethylamine. Drug interactions: May potentiate effects of anticoagulants (e.g., warfarin). A controversial 2013 study linked chronic supplementation to increased trimethylamine N-oxide (TMAO) levels, a biomarker associated with cardiovascular risk. However, subsequent research suggests this risk is context-dependent and may not apply to healthy individuals. Contraindications include uremia and seizures, where L-carnitine metabolism may be altered. Pregnant or breastfeeding women should consult healthcare providers before use. Conclusion L-Carnitine is a multifaceted molecule essential for fat metabolism, energy production, and cellular health. While supplementation benefits specific populations—such as athletes, cardiac patients, or those with deficiencies—its efficacy for general weight loss remains debated. Future research should clarify its long-term safety and interactions with gut microbiota. For now, targeted use under medical guidance offers the most promise in harnessing its metabolic advantages.
Molecular Formula	C7H15NO3
Molecular Weight	161.2g/mol
Appearance	White or almost white powder
Quality Standard	USP/EP standard; 98%- 102%(ICP-AES)
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition	Dry, dark and at 0-28℃ for short term (days to weeks) or -5-8 ℃ for long term (months to years).
Shelf Life	>2 years if stored properly
Sample package	Double plastic bags inside, fiber drum outside, any quantity available.
Commercial package	Aluminium Tin, Fiber drum
Origin	China

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FAQ

Q1. What is the Hyper chem payment term?
T/T advance
LC at sight
DP at sight
Trade assurance
Money gram

Q2. What is Hyper chem shipment policy?
Our policy is to strive for the quickest shipment time possible, with ready stock sample shipment typically going out the same day that your order was placed. Your satisfaction is very important to us.
For non-ready stock, please contact the Hyper Chem sales team to negotiate.

Q3. What hyper chem will provide after shipment?
For sample orders:
After shipment is done, an timely email including:

Track details (Fedex /TNT/DHL/EMS Track number)

Package photo

COA, MSDS, etc

Dispatch date & Estimated arriving time

Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided
in scan-copy and original, to help customers complete the customs clearance process.

Q4. What is Hyper Chem shipment term?

By Express
DHL  FedEx  TNT  EMS
Fast:5 days around
High cost, door to door service

By Air
Suitable for more than 50kg
Fast :3-7 days Hight cost, port to port, professional broker needed

By Sea
Suitable for more than 500kg
Slow:7-45 days, Low cost, port to port, professional broker needed
We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. Does hyper chem provide a shipment return policy?
Yes, we have.
Return Policy: At Hyper chem, your satisfaction is guaranteed. If you are dissatisfied for any reason with a product, please send back the unused portion along with your packing slip and a brief note on why you were dissatisfied within 45 days of purchase for a full refund to:

Q6. What is hyper chem After-sales service
•Documents support: COA ,MSDS, MOA ,MS Report,HNMR Report,SDS,DMF
• Customer Support: Shipment clearance support, quality issue support
• Automated Customer Service: Our worldwide customers enjoy immediate 24/7 access to the HYPER CHEM support team from any location, at any time.

About HyperChem

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

Pharmaceuticals
Nutrition Ingredients/ Dietary supplements
Cosmetic Ingredients
Food Ingredients
Veterinary API
Agriculture fertilizer
Custom Synthesis lab supply

HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.

Certificates

Basic Info

Product Name:

Cetirizine

Other Name:

Acetic acid,2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-;Acetic acid,[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-;2-[2-[4-[(4-Chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]acetic acid;Cetirizine;(±)-Cetirizine;Cetirizin-Teva;Piriteze;Rigix;Allamine;Cetrin;Zetrinal;(2-[4-[(4-Chloro-phenyl)-phenyl-methyl]-piperazin-1-yl]-ethoxy)-acetic acid;130018-86-9

CAS No.:

83881-51-0

Molecular Formula:

C21H25ClN2O3

InChIKeys:

InChIKey=ZKLPARSLTMPFCP-UHFFFAOYSA-N

Molecular Weight:

388.89

Exact Mass:

388.89

DSSTox ID:

DTXSID4022787

Color/Form:

Crystals from ethanol

ATC Code:

R06AE07|R - Respiratory system

HScode:

2933599090

Categories:

Nutrition Supplements

Characteristics

PSA:

XLogP3:

1.70

Appearance:

Solid

Density:

1.2±0.1 g/cm3

Melting Point:

112.5 °C

Boiling Point:

542.1±45.0 °C at 760 mmHg

Flash Point:

281.6±28.7 °C

Refractive Index:

1.589

Water Solubility:

In water, 6.96X10+4 mg/L at 25 deg C (est)

Storage Conditions:

Store at 20-25 deg C (68-77 deg F); excursions permitted to 15-30 deg C (59-86 deg F)

Vapor Pressure:

2.98X10-11 mm Hg at 25 deg C (est)

PKA:

1.52, 2.92 and 8.27

Henrys Law Constant:

Henry's Law constant = 4.19X10-17 cu cm/molec-sec at 25 °C (est)

Dissociation Constants:

1.52, 2.92 and 8.27|pKa1 = 2.70 (amine); pKa2 = 3.57 (carboxylic acid); pKa3 = 7.56 (amine) (est)

Collision Cross Section:

200.8 Å² [M+H]+ [CCS Type: TW, Method: Major Mix IMS/Tof Calibration Kit (Waters)]

Experimental Properties:

Crystals from isopropanol; mw 461.81; mp 225 °C. Soluble in water /Cetirizine dihydrochloride/|Hydroxyl radical reaction rate constant = 2.41X10-10 cu cm/molec-sec at 25 °C (est)

See More Cetirizine Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 4, Oral

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H302 Harmful if swallowed
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product.
Response	P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth.
Storage	none
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Cetirizine Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

Location:
Rm. 803, Tower 4, LOFT49 Creative City Pioneer Zone, No.88 Jiru Rd. Gongshu Dist., Hangzhou, 310015 ZJ, China

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$5 million-$10 million

Total Employees:
11-50

Year of Establishment:
2013

Certifications:
Certification Report by Bureau Veritas

About HyperChem

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to meet the needs of a diverse range of pharmaceutical cosmetics ingredients and nootropic supplements companies worldwide.

Our Competitiveness

One-stop supply

Wide Range Of products including pharmaceutical, Cosmetic Ingredients and nootropic supplements

Among all the pharmaceuticals,

90% of them with GMP certificates,

85% of them with DMF files and

50% of them passed FDA approval,

30% get CEP certificate

20% are new R&D products.

Custom Repackaging Service

We can efficiently repackage your material into sample sizes, custom batch-specific sizes, or semi-bulk package sizes according to your specifications. And ensures the product is packaged in a quality-controlled environment and will maintain its integrity throughout every stage of the process.

Quality Control/Quality Assurance

HyperChem is committed to delivering on its promises of top-quality products with verified quality data.

All materials are vigorously inspected by the factory and/or outsourced analytical laboratories to ensure each and every lot meets or exceeds our reference standards.

Trade assurance service with 100% payment protection, It is best achieved by delivering products and services 100% right the first time, on time, every time.

Professional

Transparent Communication

Fast Reaction,

Professional Suggestion

Beyond Expectation.

We have exclusive partnerships with research and production facilities across the country and we offer varied pharmaceutical services in the most cost-efficient way. The production facilities are GMP, WHO-GMP, EU GMP and US FDA approved and are backed by strong regulatory support such as Dossier, DMF, Tech Pack and relevant Stability studies for regulatory filings.

Inquiry History

2 Inquiries

Country	Product	Purchase Quantity	Date Posted
Switzerland	cetirizine	1 KG	Feb 2, 2026
United States	Cetirizine HCl	25 KG	Apr 8, 2025

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Pharmaceutical Grade 99% Cetirizine dihydrochloride/Cetirizine HCl CAS:83881-52-1

Product Description

Seller Information