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NAD+ 53-84-9

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$33-34/MT FOB

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CAS No.:

53-84-9

Grade:

Pharmaceutical Grade

Content:

99.5%

Port:

上海

Brand:

OORENT

Packaging:

Vial/Bottle/Bag/Carton

Price valid (until):

2026-07-16

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Description

Product Detail

β-Nicotinamide adenine dinucleotide Basic information

Product Name:	β-Nicotinamide adenine dinucleotide
Synonyms:	OSTEOPONTIN, GST FUSION;)-1-beta-d-ribofuranosylpyridiniumhydroxide,innersalt;adenine-nicotinamidedinucleotide;adenosine5’-(trihydrogendiphosphate),p’.fwdarw.’-esterwith3-(aminocarbonyl;Adenosine5’-(trihydrogendiphosphate),P’.fwdarw.5’-esterwith3-(aminocarbonyl)-1-.beta.-D-ribofuranosylpyridinium,innersalt;beta-diphosphopyridine;cozymasei;enzopride
CAS:	53-84-9
MF:	C21H27N7O14P2
MW:	663.43
EINECS:	200-184-4
Product Categories:	nucleoside;Biochemistry;Enzymes and Coenzymes in Nucleic Acids;Nucleosides, Nucleotides & Related Reagents;Vitamin Related Compounds;Vitamins;Bioproducts;Cofactor;Inhibitors;53-84-9
Mol File:	53-84-9.mol

β-Nicotinamide adenine dinucleotide Chemical Properties

Melting point	140-142 °C (decomp)
alpha	D20 -31.5° (c = 1.2 in water)
bulk density	200-300kg/m3
storage temp.	-20°C
solubility	H₂O: 50 mg/mL
pka	5.25
form	Powder
color	White
Odor	Odorless
PH	~3.0 (50mg/mL in water)
biological source	yeast
Water Solubility	Soluble in water at 50mg/ml
λmax	260 nm
Merck	14,6344
BRN	3584133
Stability:	Stable. Hygroscopic. Incompatible with strong oxidizing agents.
Major Application	metabolomics
Cosmetics Ingredients Functions	SKIN CONDITIONING
InChIKey	BAWFJGJZGIEFAR-WWRWIPRPSA-N
SMILES	NC1=NC=NC2=C1N=CN2.O[C@@H]3[C@@H](COP(O)(OP(OC[C@@H](O4)[C@@H](O)[C@@H](O)[C@H]4[N+]5=CC=CC(C(N)=O)=C5)([O-])=O)=O)OC[C@@H]3O
EPA Substance Registry System	Adenosine 5'-(trihydrogen diphosphate), P'.fwdarw.5'-ester with 3-(aminocarbonyl)-1-.beta.-D-ribofuranosylpyridinium, inner salt (53-84-9)

Safety Information

Hazard Codes	Xn,F,Xi
Risk Statements	36-68/20/21/22-20/21/22-40-22
Safety Statements	36-26-36/37-24/25
WGK Germany	3
RTECS	UU3450000
TSCA	TSCA listed
HS Code	29349990
Storage Class	11 - Combustible Solids

MSDS Information

Provider	Language
beta-NAD	English

β-Nicotinamide adenine dinucleotide Usage And Synthesi

Description	β-Nicotinamide adenine dinucleotide (NAD+) plays a major role in metabolism as a cofactor and mobile electron acceptor. NAD+ is a required oxidizing cosubstrate for many enzymes. It is reduced to NADH (Cat# N-035) which carries electrons to the electron transport chain for subsequent oxidative phorphorylation and ATP production. NAD+ is capable of donating ADP-ribose moieties to a protein, producing nicotinamide in the process. Sirtuin enzymes use NAD+ as a substrate to deacetylate proteins and direct activity between the nucleus and mitochondria. NAD+ is regenerated by fermentation and by oxidative phosphorylation.
Chemical Properties	β-Nicotinamide adenine dinucleotide is a hygroscopic white powder. It should be stored desiccated. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature -20°C.
History	β-Nicotinamide adenine dinucleotide was first discovered by British biochemists Arthur Harden and William John Young in 1906. They observed that the addition of boiled and filtered yeast extract significantly increased the rate of alcoholic fermentation in unboiled yeast extracts. They named the unidentified factor responsible for this effect a coferment. By extensively purifying it from yeast extracts, Hans von Euler-Chelpin identified this heat-stable factor as a nucleotide sugar phosphate. In 1936, German scientist Otto Heinrich Warburg demonstrated the role of this nucleotide coenzyme in hydride transfer and determined the nicotinamide portion as the site of redox reactions. Vitamin precursors of NAD+ were first identified in 1938, when Conrad Elvehjem showed that liver has an "anti-black tongue" activity in the form of nicotinamide. Then, in 1939, he provided the first strong evidence that niacin is used to synthesize NAD⁺.
Uses	β-Nicotinamide Adenine Dinucleotide is a coeznyme consisting of an adenine base and a nicotinamide base connected by a pair of bridging phosphate group. β-Nicotinamide Adenine Dinucleotide acts as a c oenzyme in redox reactions, as a donor of ADP-ribose moieties in ADP-ribosylation reactions and also as a precursor of the second messenger molecule cyclic ADP-ribose. β-Nicotinamide Adenine Dinucleot ide also acts as a substrate for bacterial DNA ligases and a group of enzymes called sirtuins that use NAD+ to remove acetyl groups from proteins.
Application	β-Nicotinamide adenine dinucleotide (β-NAD) is a cofactor of alcohol dehydrogenase and acts as a neuromodulator and an inhibitory neurotransmitter in visceral smooth muscles. The NAD/NADH ratio has a role in the regulation of intracellular redox potential. It thereby influences metabolic reactions in vivo. It has been used for the preparation of deacetylated tubulin. It has also been used for UDP-glucose-6-hydrogenase (UGDH) enzyme activity assay of orital fibroblast cell lysates. β-Nicotinamide adenine dinucleotide (NAD+) and β-Nicotinamide adenine dinucleotide, reduced (NADH) comprise a coenzyme redox pair (NAD+:NADH) involved in a wide range of enzyme catalyzed oxidation reduction reactions. In addition to its redox function, NAD+/NADH is a donor of ADP-ribose units in ADP-ribosylaton (ADP-ribosyltransferases; poly(ADP-ribose) polymerases ) reactions and a precursor of cyclic ADP-ribose (ADP-ribosyl cyclases).
Definition	ChEBI: β-Nicotinamide adenine dinucleotide (NAD) is the oxidized form of β-Nicotinamide Adenine Dinucleotide. It exists as an anion under normal physio-logic conditions. It is functionally related to a deamido-NAD zwitterion. It is a conjugate base of a NAD(+). It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
benefits	The benefits of NAD+Therapy directly related to mental health treatment include: Restores cellular energy, metabolism and promotes cellular repair Helps regulate cellular defense and reduces inflammation Elevates mood and generates the feeling of calmness and happiness Supports healthy aging and cognitive function NAD infusion therapy is most effective when multiple infusions are conducted regularly over time. Long-term maintenance and cellular support contribute to less overall damage to your mitochondria, a slower aging rate, and better cognitive health.
General Description	β-Nicotinamide adenine dinucleotide (NAD) is a ubiquitously found electron carrier and a cofactor. NAD⁺ contains an adenylic acid and a nicotinamide-5′-ribonucleotide group linked together by a pyrophosphate moiety. In NAD⁺ complexes, the enzyme-cofactor interactions are highly conserved.
Biological Activity	NAD+, known more formally as nicotinamide adenine dinucleotide, is a signaling molecule as well as a cofactor or substrate for many enzymes. It acts as an oxidizing agent, accepting electrons from other molecules while being converted to its reduced form, NADH. NAD+ is also essential for the activity of several enzymes, including poly(ADP)-ribose polymerases and cADP-ribose synthases. For example, it is used by some sirtuins to mediate protein deacetylation, producing O-acetyl-ADP-ribose and nicotinamide as well as the deacetylated protein.
Biochem/physiol Actions	β-Nicotinamide adenine dinucleotide (β-NAD) is an electron carrier and a cofactor, significantly involved in enzyme-catalyzed oxido-reduction processes and many genetic processes. NAD cycles between the oxidized (NAD+) and reduced (NADH) forms to maintain a redox balance necessary for continued cell growth. NAD is also involved in microbial catabolism. β-NAD acts as a substrate for various enzymes in several cellular processes.
Side effects	In the studies conducted thus far, people taking between 1000mg-2000mg per day have reported zero long term side effects. However, during the active infusion, some people may feel temporary nausea or stomach discomfort.
Synthesis	CN201511022464.3 presents a method for preparing a nicotinamide adenine dinucleotide, comprising the steps of: S1, breaking cells: yeast cells are added to an aqueous hydrochloric acid solution and soaked for 0.5-2.5h, after temperature difference wall-breaking treatment, filtered with a ceramic membrane, and the filtrate is taken to obtain clear liquid A; S2, concentration: take the clear liquid A obtained in S1 ultrafiltration, take the ultrafiltration solution nanofiltration to get the concentrate B, use hydrochloric acid aqueous solution to adjust the pH of the concentrate B = 2-2.5 to get the concentrate C; S3, elution: the concentrate C obtained in S2 was passed through a D152 resin column, eluted with ammonia, and the eluate D was collected, and the pH of the eluate D was adjusted with aqueous hydrochloric acid to be 7-8, then it was passed through a 717 resin column, and the eluate was eluted with aqueous potassium chloride, and the synthesized solution E was collected; S5, purification: the solid G obtained in S4 was dissolved with water, prepared chromatography, desalination, separation, collection of the isolate, concentration, lyophilization to obtain nicotinamide adenine dinucleotide.
Purification Methods	The column is prepared by washing with 3M HCl until free of material absorbing at 260nm, then with water, 2M sodium formate until free of chloride ions and, finally, with water. NAD, as a 0.2% solution in water, is adjusted with NaOH to pH 8, and adsorbed onto the column, washed with water, and eluted with 0.1M formic acid. Fractions with strong absorption at 360nm are combined, acidified to pH 2.0 with 2M HCl, and cold acetone (ca 5L/g of NAD) is added slowly and with constant agitation. It is left overnight in the cold, then the precipitate is collected in a centrifuge, washed with pure acetone and dried under vacuum over CaCl2 and paraffin wax shavings [Kornberg Methods Enzymol 3 876 1957]. It has been purified by anion-exchange chromatography [Dalziel & Dickinson Biochemical Preparations 11 84 1966.] The purity is checked by reduction to NADH (with EtOH and yeast alcohol dehydrogenase) which has 340mn 6220 M-1cm-1. [Todd et al. J Chem Soc 3727, 3733 1957.] [pKa, Lamborg et al. J Biol Chem 231 685 1958.] The free acid crystallises from aqueous Me2CO with 3H2O and has m 140-142o. It is stable in cold neutral aqueous solutions in a desiccator (CaCl2) at 25o, but decomposes at strong acid and alkaline pH. Its purity is checked by reduction with yeast alcohol dehydrogenase and EtOH to NADH and noting the OD at 340nm. Pure NADH (see below) has 340 6.2 x 104 M-1cm-1, i.e. 0.1mole of NADH in 3mL and in a 1cm path length cell has an OD at 340nm of 0.207. [Beilstein 26 IV 3644.]
References	1. Pollak N.; Dlle C.; Ziegler M. The power to reduce: pyridine nucleotides - small molecules with a multitude of functions. Biochem. J. 2007, 402(2), 205-18. DOI:10.1042/BJ20061638 2. Unden G, Bongaerts J. Alternative respiratory pathways of Escherichia coli: energetics and transcriptional regulation in response to electron acceptors. Biochim. Biophys. Acta. 1997, 1320(3), 217-34. DOI:10.1016/S0005-2728(97)00034-0 3. Houtkooper, R.H., Cantó, C., Wanders, R.J., et al. The secret life of NAD+: An old metabolite controlling new metabolic signaling pathways. Endocr. Rev. 31(2), 194-223 (2010). DOI:10.1210/er.2009-0026 4. Experimental and theoretical electron density studies in large molecules: NAD+, beta-nicotinamide adenine dinucleotide DOI:10.1021/JP034478B 5. A Mechanism of Adsorption of beta-Nicotinamide Adenine Dinucleotide on Graphene Sheets: Experiment and Theory DOI:10.1002/chem.200900399 6. β-Nicotinamide Adenine Dinucleotide (β-NAD) Inhibits ATP-Dependent IL-1β Release from Human Monocytic Cells DOI:10.3390/ijms19041126 7. Oxidation of β-Nicotinamide Adenine Dinucleotide (NADH) by Au Cluster and Nanoparticle Catalysts Aiming for Coenzyme Regeneration in Enzymatic Glucose Oxidation DOI:10.1021/acssuschemeng.0c01893

β-Nicotinamide adenine dinucleotide Preparation Products And Raw materials

Raw materials	Ammonia-->Potassium chloride-->AMBERLITE(R) IRC-50-->Yeast extract-->Anion exchange resin,strong basic quarternary ammoniumⅠ-->Cation exchange resin,weak acidic acrylic acid-->Cation exchange resin,strong acidic styrene 001×7×7
Preparation Products	CADP-RIBOSE-->NADPH

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Basic Info

Product Name:

NAD

Other Name:

Adenosine 5′-(trihydrogen diphosphate),P′→5′-ester with 3-(aminocarbonyl)-1-β-D-ribofuranosylpyridinium,inner salt;Pyridinium,3-carbamoyl-1-β-D-ribofuranosyl-,hydroxide,5′→5′-ester with adenosine 5′-(trihydrogen pyrophosphate),inner salt;Adenosine 5′-(trihydrogen diphosphate),P′→5′-ester with 3-(aminocarbonyl)-1-β-D-ribofuranosylpyridinium hydroxide,inner salt;Codehydrase I;Codehydrogenase I;Coenzyme I;Diphosphopyridine nucleotide;DPN;Cozymase I;NAD;Nadide;Nicotinamide-adenine dinucleotide;Oxidized diphosphopyridine nucleotide;Adenine-nicotinamide dinucleotide;NAD+;Enzopride;β-NAD;β-Diphosphopyridine nucleotide;β-Nicotinamide adenine dinucleotide;β-NAD+;NSC 20272;CO-I;β-Nicotinamide adenine dinucleotide hydrate;30429-30-2;159929-29-0;1083039-67-1;1354693-98-3

CAS No.:

53-84-9

Molecular Formula:

C21H27N7O14P2

InChIKeys:

InChIKey=BAWFJGJZGIEFAR-NNYOXOHSSA-N

Molecular Weight:

663.43

Exact Mass:

663.109131

EC Number:

200-184-4

NSC Number:

757121

DSSTox ID:

DTXSID2045236

NCI Thesaurus Code:

C87339

HScode:

29349990

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

321

XLogP3:

-1.29620

Appearance:

White Powder

Melting Point:

140-142 °C (decomp)

Water Solubility:

soluble in water at 50mg/ml

Storage Conditions:

2-8°C

Specific rotation:

D20 -31.5° (c = 1.2 in water)

Collision Cross Section:

226.7 Å² [M+H]+ [CCS Type: DT, Method: single field calibrated with Agilent tune mix (Agilent)]|227.5 Å² [M+H]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|222.7 Å² [M+Na]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|223.8 Å² [M-H]- [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|230.8 Å² [M+Na-2H]- [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|227 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

See More NAD Properties 

Hazard Identification

Classification of the substance or mixture

Not classified.

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	No symbol.
Signal word	No signal word
Hazard statement(s)	none
Prevention	none
Response	none
Storage	none
Disposal	none

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More NAD Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

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We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
Integrity is the foundation, quality is life. We would like to work together with you to build a greener and brighter future.

Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

121 Inquiries

Country	Product	Purchase Quantity	Date Posted
United Kingdom	NAD+ 99% powder CAS 53-84-9 DISHA	1 KG	Aug 13, 2023
United States	Nad+ Injection 500mg/1000mg 99% Purity CAS 53-84-9 USP in 1000mg vials	1000 G	Jan 12, 2024
United States	holesale CAS 53-84-9 99% β-Nicotinamide adenine dinucleotide 99% white powder 99% WP	1 KG	Feb 10, 2025
United Kingdom	Top Quality 99% Purity Nicotinamide Adenine Dinucleotide Powder Nad CAS 53-84-9 Nad+	5 G	Oct 25, 2023
United Kingdom	NAD+	2 KG	Mar 4, 2024
India	ß-Nicotinamide Adenine Dinucleotide hydrate	1.00 KG	Jan 29, 2026
United States	NAD+ lyophilized powder pure Pharacuetical Grade	500 G	Apr 15, 2026
India	Nicotinamide adenine dinucleotide	300.00 G	Jan 10, 2024
Turkey	b-Nicotinamide adenine dinucleotide	1 KG	Sep 7, 2023
India	Nicotinamide Adenine Dinucleotide Iv Vials	1.00 KG	Sep 12, 2023
India	beta-Diphosphopyridine nucleotide	100 KG	Apr 16, 2024
India	ß-Nicotinamide Adenine Dinucleotide hydrate, oxidised form (NAD)	1.00 KG	Jul 13, 2023
India	Nicotinamide Adenine Dinucleotide	25 KG	Apr 7, 2025
United States	Beta-Nicotinamide adenine dinucleotide Nad+	1 MG	Jun 18, 2026
Australia	Nad	10 MG	Jun 16, 2026
United States	nad	1 G	Jun 11, 2026
United States	NAD	1 G	Jun 5, 2026
United States	NAD +	1 MT	Jun 4, 2026
Germany	NAD+ Peptide \| 99% Purity \| 500mg Lyophilized Powder	10 PCS	May 30, 2026
United States	NAD+	1 KG	May 26, 2026

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NAD+ 53-84-9

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