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4-Aminopyridine504-24-5C5H6N2

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Unit Price:

$33-34/MT FOB

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CAS No.:

504-24-5

Grade:

Pharmaceutical Grade

Content:

99.5%

Port:

上海

Brand:

OORENT

Packaging:

Vial/Bottle/Bag/Carton

Price valid (until):

2026-07-16

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Qingdao Orient Chemical Co.,LTD

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Trader

Location:

China

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pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
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Inquiry History

Description

Product Detail

4-Aminopyridine Basic information

Product Name:	4-Aminopyridine
Synonyms:	4-Aminopyridine,98%;4-AMINOPYRIDINE,REAGENT;AMINOPYRIDINE, 4-(P);PARA-AMINOPYRIDINE;4-AMINO PYRIDINE PYRIDIN-4-YLAMINE;Phillips 1861;phillips1861;Pimadin (free base)
CAS:	504-24-5
MF:	C5H6N2
MW:	94.11
EINECS:	207-987-9
Product Categories:	A;Alphabetical Listings;Pyridine;Stable Isotopes;Potassium channel;Ion Channels;Organics;Amines;Pyridines;Pyridines derivates;Heterocyclic Compounds;amine;Amines, Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals;SERMION;Azetidines;504-24-5
Mol File:	504-24-5.mol

4-Aminopyridine Chemical Properties

Melting point	155-158 °C (lit.)
Boiling point	273 °C (lit.)
density	1.26
vapor pressure	0.046Pa at 25℃
refractive index	1.5560 (estimate)
Fp	156°C
storage temp.	2-8°C
solubility	H2O: soluble50mg/mL, clear, colorless
pka	9.114(at 25℃)
form	Crystalline Powder, Solid or Crystals
color	White to faint grey to light yellow
Water Solubility	Soluble in water(112 g/L at 20°C). Soluble in ethyl ether, benzene. Slightly soluble in ligroin. Very soluble in ethanol. Soluble in methanol, acetone, tetrahydrofuran, isopropanol, acetonitrile, N,N-dimethylformamide, dimethylsulfoxide, and ethanol.
Merck	14,3933
BRN	105782
Henry's Law Constant	4.3×10⁴ mol/(m³Pa) at 25℃, HSDB (2015)
Stability:	Hygroscopic
Major Application	agriculture environmental
InChI	1S/C5H6N2/c6-5-1-3-7-4-2-5/h1-4H,(H2,6,7)
InChIKey	NUKYPUAOHBNCPY-UHFFFAOYSA-N
SMILES	Nc1ccncc1
LogP	-0.76 at pH7.4
CAS DataBase Reference	504-24-5(CAS DataBase Reference)
NIST Chemistry Reference	4-Pyridinamine(504-24-5)
EPA Substance Registry System	4-Aminopyridine (504-24-5)

Safety Information

Hazard Codes	T+,N,T,Xi
Risk Statements	28-36/37/38-51/53-23/24/25
Safety Statements	26-36/37/39-45-60-61-37/39-28A-1
RIDADR	UN 2671 (AMINOPYRIDINES (o-, m-, p,))
WGK Germany	3
RTECS	US1750000
F	8-21
Autoignition Temperature	640 °C
Hazard Note	Toxic/Irritant
TSCA	TSCA listed
HazardClass	6.1
PackingGroup	II
HS Code	29333999
Storage Class	6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials
Hazard Classifications	Acute Tox. 2 Oral Acute Tox. 3 Dermal Acute Tox. 3 Inhalation Aquatic Chronic 2 Eye Dam. 1 Skin Corr. 1B
Hazardous Substances Data	504-24-5(Hazardous Substances Data)
Toxicity	LD50 orally in Rabbit: 21 mg/kg

4-Aminopyridine Usage And Synthesis

Description	4-Aminopyridine (4-AP, fampridine, dalfampridine) is the first drug approved by the FDA to improve walking in patients with multiple sclerosis (MS). Dalfampridine is a voltage-gated potassium channel blocker that readily penetrates the CNS and increases the conduction and duration of action potential across nerve fibers resulting in enhanced functionality as observed in the walking speed of MS patients. Besides, it has repellent–toxicant properties for birds.
Chemical Properties	4-aminopyridine is a white crystalline solid that contains about 98% active ingredient. It is soluble in water and slightly soluble in benzene and ether. 4-Aminopyridine formulations are classifi ed by the US Environmental Protection Agency (US EPA) as restricted use pesticides (RUPs) and therefore should be purchased and used only by certifi ed and trained workers and applicators.
Originator	Rush University Medical Center (United States)
Uses	Avitrol (4-aminopyridine), has repellent–toxicant properties for birds and is classed as a severe poison and irritant. This secondary bird repellent can be used as a broadcast bait, causing uncoordinated flight and distress calls and escape responses in nearby birds.
Uses	Dalfampridine is used in characterizing subtypes of potassium channel, and has also been used to manage some of the symptoms of multiple sclerosis, and is indicated for symptomatic improvement of walking in adults with several variations of the disease. Dalfampridine is a precursor to the drug Pinacidil.
Definition	ChEBI: 4-aminopyridine is an aromatic amine that is pyridine bearing a single amino substituent at position 4. An orphan drug in the US, it is used to improve walking in adults with multiple sclerosis. It has a role as an avicide, a potassium channel blocker and an orphan drug. It is an aromatic amine and an aminopyridine.
Brand name	Neurelan (E′lan);Ampyra.
Synthesis Reference(s)	Tetrahedron Letters, 39, p. 1313, 1998 DOI: 10.1016/S0040-4039(97)10877-2
General Description	White crystalline material with no odor. Used as an avicide, an intermediate and as a fixer for some textile dyes.
Reactivity Profile	4-Aminopyridine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
Health Hazard	4-Aminopyridine, a pyridine compound, is an extremely effective bird poison. In agriculture, 4-AP is used as an extremely effective bird poison sold under the brand name Avitrol. It is highly toxic to all mammals including humans if dosages are exceeded, and as an experimental drug, the recommended dose data is unavailable.
Fire Hazard	Material may produce irritating or poisonous gases in fire. Runoff from fire control water may give off irritating or poisonous gases.
Agricultural Uses	4-Aminopyridine is used commercially as a bird repellent and often is mixed with grain before its distribution.
Safety Profile	Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects by ingestion: hallucinations and vomiting. When heated to decomposition it emits toxic fumes of NOx,.
Potential Exposure	Used as a chemical intermediate in pharmaceuticals; as an agricultural chemical for field crops; and as a bird repellent and poison
in vitro	4-ap acts by selectively blocking fast, voltage-gated k+ channels in excitable tissues. in axons, k+ channel blockade increases the safety factor1 across demyelinated internodes and 4-ap can, therefore, restore conduction in focally demyelinated axons. 4-ap also increases calcium (ca2+) influx at presynaptic terminals thereby enabling an enhancement of neuroneuronal or neuromuscular transmission in normally myelinated neurons [1].
in vivo	investigations of the effects of 4-ap on neurologic deficits in animal in vivo models of demyelinating disease or sci have yielded inconsistent results. some trials have shown indications of potential neurological benefit, such as enhanced motor evoked potentials or reflex activity, while others have yielded no evident gains in function [1].
IC 50	170 and 230 μm at kv1.1 and kv1.2, respectively
storage	Room temperature
Shipping	UN2671 Aminopyridines, Hazard Class: 6.1; Labels: 6.1-Poisonous materials
Purification Methods	Crystallise the aminopyridine from benzene/EtOH, then recrystallise it twice from water, then crush and dry it for 4hours at 105o [Bates & Hetzer J Res Nat Bur Stand 64A 427 1960]. It has also been crystallised from EtOH, benzene, *benzene/pet ether, toluene and sublimes in a vacuum. [Beilstein 22/9 V 106.]
Toxicity evaluation	4-Aminopyridine is highly toxic to animals, with an approximate oral LD50 of 3.7 mg/kg body weight in the dog. 4-Aminopyridine blocks potassium channels, resulting in increased cholinergic nervous system activity. Clinical signs in poisoned animals often develop within several hours of ingestion and commonly include tachycardia, salivation, tremors, ataxia, and seizures. Death from respiratory failure may develop within 4 hours of exposure.
Incompatibilities	Sodium nitrite, strong oxidizers. Avoid contact with acid anhydrides, acid chlorides; and strong acids.
Waste Disposal	Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposalIncineration with nitrogen oxides removal from effluent gas.
references	[1] hayes kc. the use of 4-aminopyridine (fampridine) in demyelinating disorders. cns drug rev. 2004 winter;10(4):295-316.

4-Aminopyridine Preparation Products And Raw materials

Raw materials

Potassium carbonate-->Phthalic acid-->Pyridine-N-oxide-->4-Nitropyridine

Preparation Products

4-ACETAMIDO-3-AMINOPYRIDINE-->(3-BROMO-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER-->2,2-DIMETHYL-N-PYRIDIN-4-YL-PROPIONAMIDE-->4-(Boc-amino)pyridine-->3-PYRIDINEACETIC ACID, 4-[[(1,1-DIMETHYLETHOXY)CARBONYL]AMINO]-A-OXO-, ETHYL ESTER-->TERT-BUTYL 3-FORMYLPYRIDIN-4-YLCARBAMATE-->efficient polymer catalyst for acrylation-synthesis and characterigation of polyamide containing supernucleophilic reagent-->4-Iodopyridine-->2-chloro-5-ethylaminomethylpyridine-->4-Amino-3-nitropyridine-->4-Amino-2-bromopyridine-->4-PYRIDYLTHIOUREA-->3,4-DiaMino-5-broMo-2-chloropyridine-->4-chloropyridine-->2,7-di(pyridin-4-yl)benzo[lMn][3,8]phenanthroline-1,3,6,8(2H,7H)-tetraone-->4-Amino-3-(trifluoromethyl)pyridine

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Basic Info

Product Name:

4-Aminopyridine

Other Name:

4-Pyridinamine;Pyridine,4-amino-;4-Aminopyridine;VMI 10-3;Phillips 1861;γ-Aminopyridine;p-Aminopyridine;4-Pyridylamine;Avitrol;EL 970;Fampridine;4-Pyridinylamine;4AP;NSC 15041;Neurelan;Ampyra;Dalfampridine;Pymadin;Fampyra

CAS No.:

504-24-5

Molecular Formula:

C5H6N2

InChIKeys:

InChIKey=NUKYPUAOHBNCPY-UHFFFAOYSA-N

Molecular Weight:

94.11

Exact Mass:

94.11

BRN:

105782

EC Number:

207-987-9

HScode:

29333999

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

38.9

XLogP3:

0.32

Appearance:

White to faint grey to light yellow Crystalline Powder, Solid or Crystals

Density:

1.26

Melting Point:

158.5 °C

Boiling Point:

273 °C

Flash Point:

156°C

Refractive Index:

1.569

Water Solubility:

soluble in water(112 g/L at 20 deg C). soluble in ethyl ether, benzene. Slightly soluble in ligroin. Very soluble in ethanol. soluble in methanol, acetone, tetrahydrofuran, isopropanol, acetonitrile, N,N-dimethylformamide, dimethylsulfoxide, and ethanol.

Storage Conditions:

0-6°C

Vapor Pressure:

2.09X10-4 mm Hg at 20 deg C

Toxicity:

Oral-Rat LD50: 21 mg/kg; Oral-Mouse LD50: 42 mg/kg

Flammability characteristics:

Open flame is flammable; high heat emits toxic nitrogen oxide gas

Odor:

Odorless

PKA:

11None

See More 4-Aminopyridine Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 2, Oral

Skin irritation, Category 2

Eye irritation, Category 2

Specific target organ toxicity â single exposure, Category 3

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H300 Fatal if swallowed H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation H411 Toxic to aquatic life with long lasting effects
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area. P273 Avoid release to the environment.
Response	P301+P316 IF SWALLOWED: Get emergency medical help immediately. P321 Specific treatment (see ... on this label). P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P319 Get medical help if you feel unwell. P391 Collect spillage.
Storage	P405 Store locked up. P403+P233 Store in a well-ventilated place. Keep container tightly closed.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Keep container tightly closed in a dry and well-ventilated place.

See More 4-Aminopyridine Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

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We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
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Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

3 Inquiries

Country	Product	Purchase Quantity	Date Posted
Brazil	4-Aminopyridine	50 G	Dec 5, 2023
India	4 amino Pyridine	1.00 MT	Oct 15, 2025
United States	4-Aminopyridine	100 G	Aug 24, 2024

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