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4-Aminopyridine

4-Aminopyridine structure

CAS No:
504-24-5
Formula:
C5H6N2
Chemical Name:
4-Aminopyridine
Synonyms:
4-Pyridinamine;Pyridine,4-amino-;4-Aminopyridine;VMI 10-3;Phillips 1861;γ-Aminopyridine;p-Aminopyridine;4-Pyridylamine;Avitrol;EL 970;Fampridine;4-Pyridinylamine;4AP;NSC 15041;Neurelan;Ampyra;Dalfampridine;Pymadin;Fampyra
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

Description

4-Aminopyridine is a nonselective K+ channel blocker that binds from the cytoplasmic side of the cell membrane.Target: Potassium Channel4-Aminopyridine(4AP) is a nonselective K+ channel blocker that binds from the cytoplasmic side of the cell membrane. 4AP strongly potentiates transmitter release from the unmyelinated terminals of rat motor nerves, and the possibility arose that demyelinated axon membrane, which can conduct impulses continuously like an unmyelinated fibre, might further

4-Aminopyridine Basic Attributes

Molecular Weight：

94.11

Exact Mass：

94.11

BRN：

105782

EC Number：

207-987-9

HScode：

29333999

Characteristics

PSA：

38.9

XLogP3：

0.32

Appearance：

White to faint grey to light yellow Crystalline Powder, Solid or Crystals

Density：

1.26

Melting Point：

158.5 °C

Boiling Point：

273 °C

Flash Point：

156°C

Refractive Index：

1.569

Water Solubility：

soluble in water(112 g/L at 20 deg C). soluble in ethyl ether, benzene. Slightly soluble in ligroin. Very soluble in ethanol. soluble in methanol, acetone, tetrahydrofuran, isopropanol, acetonitrile, N,N-dimethylformamide, dimethylsulfoxide, and ethanol.

Storage Conditions：

0-6°C

Vapor Pressure：

2.09X10-4 mm Hg at 20 deg C

Toxicity：

Oral-Rat LD50: 21 mg/kg; Oral-Mouse LD50: 42 mg/kg

Flammability characteristics：

Open flame is flammable; high heat emits toxic nitrogen oxide gas

Odor：

Odorless

PKA：

11None

Safety Information

Packing level：

Hazard category：

6.1

Transport codes：

UN 2671 6.1/PG 2

wgk germany：

hazard class code：

28-36/37/38-51/53-23/24/25

safety instructions：

26-36/37/39-45-60-61-37/39-28A-1

RTECS Number：

US1750000

Marks：

T+,N,T,Xi

Storage features：

The warehouse is ventilated at low temperature and dry; stored separately from oxidants, acids and food additives

Hazard note：

Toxic/Irritant

Stability/Shelf Life：

Stable to light.

Precautionary statement(s)：

P261-P264-P301 + P310-P305 + P351 + P338

Hazard Statements：

H300-H315-H319-H335

Toxicity

Toxicity class：

most toxic

4-Aminopyridine Use and Manufacturing

Dalfampridine is used in characterizing subtypes of potassium channel, and has also been used to manage some of the symptoms of multiple sclerosis, and is indicated for symptomatic improvement of walking in adults with several variations of the disease. Dalfampridine is a precursor to the drug Pinacidil.

Computed Properties

Molecular Weight:94.11
XLogP3:0.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Exact Mass:94.053098200
Monoisotopic Mass:94.053098200
Topological Polar Surface Area:38.9
Heavy Atom Count:7
Complexity:48
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Potassium carbonate

N-Methyl-2-pyrrolidone

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4-Aminopyridine (4-AP)

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