2-erhoxy-5-fluorouracil

# Introduction of 2-Ethoxy-5-fluoro-1H-pyrimidin-4-one CAS No.: 56177-80-1 Chinese Name: 2-Ethoxy-5-fluorouracil ## Basic Information 2-Ethoxy-5-fluoro-1H-pyrimidin-4-one is a fluoropyrimidine derivative with a pyrimidinone parent ring structure. It features an ethoxy group at the C2 position and a fluorine substituent at the C5 position of the pyrimidine ring, making it a key intermediate for the synthesis of fluoropyrimidine anti-tumor and pharmaceutical active ingredients. Its molecular skeleton is structurally related to 5-fluorouracil, and the ethoxy modification optimizes its lipophilicity and metabolic stability for downstream synthetic routes. ## Physical & Chemical Properties This compound is a white to off-white solid under normal temperature and pressure. It has moderate solubility in common organic solvents including methanol, ethanol, dichloromethane and acetonitrile, while it is barely soluble in water. The fluorine atom on the pyrimidine ring improves molecular binding affinity with biological targets, and the 2-ethoxy group serves as a modifiable protecting group that can be cleaved or substituted in subsequent synthetic steps to construct complex pyrimidine APIs. It maintains stable chemical properties under dry, cool storage conditions and avoids exposure to strong acids, strong alkalis and high temperature to prevent ring-opening decomposition. ## Main Application 1. Pharmaceutical Synthetic Intermediate It is a core building block for manufacturing fluoropyrimidine anti-cancer drugs. Through hydrolysis, amination and cyclization reactions, it can be converted into multiple targeted anti-tumor active substances derived from 5-fluorouracil series, which interfere with tumor cell nucleic acid synthesis and inhibit cancer cell proliferation. 2. Biochemical Research Reagent Applied in laboratory studies of pyrimidine metabolic pathways, as a structural analog probe to explore the mechanism of fluoropyrimidine cytotoxicity against tumor cells. 3. Custom Fine Chemical Raw Material Supplied for custom pharmaceutical synthesis, peptide-drug conjugate preparation and medical chemistry contract research organizations (CROs). ## Storage & Handling Notes Seal tightly and store in a cool, dry, ventilated warehouse away from light, moisture and oxidants. Wear standard lab protective equipment (gloves, goggles, dust mask) during weighing and transfer operations. Separate from food, daily chemicals and strong corrosive reagents to avoid cross-contamination. ## Quality Control Reference The purity of commercial grade material is typically controlled above 98% via HPLC. Routine test items include melting point, water content, residual organic solvents and related impurity profiles, with full COA documents provided for export customs clearance and pharmaceutical registration.