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Trifluoroacetic anhydride407-25-0

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$33-34/MT FOB

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CAS No.:

407-25-0

Grade:

Industrial Grade

Content:

99.5%

Port:

上海

Brand:

OORENT

Packaging:

Vial/Bottle/Bag/Carton

Price valid (until):

2026-07-17

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

Qualification:

Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
Seller Information
Inquiry History

Description

Product Detail

Trifluoroacetic anhydride Basic information

Product Name:	Trifluoroacetic anhydride
Synonyms:	TIFLUOROACETIC ANHYDRIDE;TRIFLUOROACETO ANHYDRIDE;Trifluoroacetic acid anhydride (TFAH);RIFLUOROACETIC ANHYDRIDE;Trifluoroacetic anhydride 10g [407-25-0];Trifluoroacetic anhy;Trifluoroacetic anhydride, min. 98%;trifluoroacetyl 2,2,2-trifluoroacetate
CAS:	407-25-0
MF:	C4F6O3
MW:	210.03
EINECS:	206-982-9
Product Categories:	Pharmaceutical intermediates;Acylation Reagent;Halogen compounds;Organic Fluorides;Building Blocks;top;Acylation (GC Derivatizing Reagents);Analytical Chemistry;Fluorinated Building Blocks;organofluorine compound;Carbonyl Compounds;Carboxylic Acid Anhydrides;Chemical Synthesis;Organic Building Blocks;Organics;Fluorinating Reagents & Building Blocks for Fluorinated Biochemical Compounds;GC Derivatizing Reagents;Synthetic Organic Chemistry;407-25-0;K00001
Mol File:	407-25-0.mol

Trifluoroacetic anhydride Chemical Properties

Melting point	-65 °C (lit.)
Boiling point	39.5-40 °C (lit.)
density	1.511 g/mL at 20 °C (lit.)
vapor pressure	6.28 psi ( 20 °C)
refractive index	n20/D 1.3(lit.)
Fp	-26 °C
storage temp.	2-8°C
solubility	Miscible with benzene, dichloromethane, diethyl ether, dimethylformamide, terahydrofuran and acetonitrile.
form	Liquid
pka	0.43[at 20 ℃]
color	Clear
Specific Gravity	1.487
Water Solubility	Hydrolysis
Sensitive	Moisture Sensitive
BRN	746197
Stability:	Stable, but moisture sensitive. Reacts with water to liberate hydrogen (flammable!). Incompatible with water, strong oxidizing agents.
InChI	1S/C4F6O3/c5-3(6,7)1(11)13-2(12)4(8,9)10
InChIKey	QAEDZJGFFMLHHQ-UHFFFAOYSA-N
SMILES	FC(F)(F)C(=O)OC(=O)C(F)(F)F
LogP	0.79 at 25℃
CAS DataBase Reference	407-25-0(CAS DataBase Reference)
NIST Chemistry Reference	Acetic acid, trifluoro-, anhydride(407-25-0)
EPA Substance Registry System	Acetic acid, trifluoro-, anhydride (407-25-0)

Safety Information

Hazard Codes	C,T
Risk Statements	14-20-35-52/53-34-23/24/25
Safety Statements	26-36/37/39-43-45-61-9-8-28A-27
RIDADR	UN 3265 8/PG 1
WGK Germany	2
RTECS	AJ9800000
F	3-10
Hazard Note	Corrosive/Moisture Sensitive
TSCA	TSCA listed
HazardClass	8
PackingGroup	I
HS Code	29159080
Storage Class	8B - Non-combustible corrosive hazardous materials
Hazard Classifications	Acute Tox. 4 Inhalation Aquatic Chronic 3 Eye Dam. 1 Skin Corr. 1A
Toxicity	skn-rbt 500 mg/24H SEV 28ZPAK -,91,72

MSDS Information

Provider	Language
2,2,2-Trifluoroacetic anhydride	English
SigmaAldrich	English
ACROS	English
ALFA	English

Trifluoroacetic anhydride Usage And Synthesis

Description	Trifluoroacetic acid anhydride (TFAA), a perfluoroacylated acylation reagent, forms stable, volatile derivatives with alcohols, amines, and phenols.
Chemical Properties	Clear, colorless liquid
Uses	Used as analytical reagents, solvents, catalysts, dehydration condensing agent, protection agent of trifluoroacetylation of carboxyl and amino; used as Intermediate of fluorine fine chemicals, pharmaceutical, agrochemical.
Uses	Trifluoroacetic anhydride is used for the introduction of trifluoroacetyl group in organic synthesis. It is involved in the preparation of N- and O-trifluoroacetyl derivatives of a wide range of biologically active compounds for gas chromatography analysis. It plays an important role as desiccant for trifluoroacetic acid. It is also used in the oxidation of aldehydes to acids, esters, amides as well as in the protection of alcohols and amines. In addition, it is used as analytical reagents, solvents and dehydration condensing agent. It serves as an intermediate of fluorine fine chemicals, pharmaceuticals and agrochemicals.
Preparation	Trifluoroacetic anhydride is prepared by reaction of trifluoroacetyl chloride with an alkali metal or alkaline-earth metal salt of trifluoroacetic acid at approximately 50° C.
reaction suitability	reagent type: derivatization reagent reaction type: Acylations reagent type: derivatization reagent reaction type: Esterifications
Safety Profile	A severe skin and eye irritant.Explosive reaction with dimethyl sulfoxide; nitric acid +1,3,5-triazine (at 36°C); nitric acid + 1,3,5-triacetylhexahydro-1,3,5-triazine (at 30°C). Incompatiblewith lithium tetrahydroaluminate. When heated todecomposit
Purification Methods	Purification by distilling over KMnO4, as for the acid above, is EXTREMELY DANGEROUS due to the possiblility of EXPLOSION. It is best purified by distilling from P2O5 slowly, and collecting the fraction boiling at 39.5o. Store it in a dry atmosphere. Highly TOXIC vapour and attacks skin, work in an efficient fume hood. [Beilstein 2 IV 469.]

Trifluoroacetic anhydride Preparation Products And Raw materials

Raw materials

Trifluoroacetic acid-->DICHLOROACETIC ANHYDRIDE

Preparation Products

Shop 3-Chloro-1-propene107-05-1-Detailed Image 2

Basic Info

Product Name:

Trifluoroacetic anhydride

Other Name:

Acetic acid,2,2,2-trifluoro-,1,1′-anhydride;Acetic acid,trifluoro-,anhydride;Trifluoroacetic anhydride;Perfluoroacetic anhydride;Trifluoroacetic acid anhydride;Hexafluoroacetic anhydride;Trifluoroacetyl anhydride;Bis(trifluoroacetic) anhydride;2,2,2-Trifluoroacetic anhydride;NSC 96965;(2,2,2-Trifluoroacetyl) 2,2,2-trifluoroacetate

CAS No.:

407-25-0

Molecular Formula:

C4F6O3

InChIKeys:

InChIKey=QAEDZJGFFMLHHQ-UHFFFAOYSA-N

Molecular Weight:

210.03100

Exact Mass:

210.03

EC Number:

206-982-9

UNII:

5ENA87IZHT

NSC Number:

96965

HScode:

29159080

Categories:

Pesticide Intermediates

Characteristics

PSA:

43.37000

XLogP3:

1.18080

Appearance:

Liquid

Density:

1.490 g/cm³ @ Temp: 25 °C

Melting Point:

-65 °C

Boiling Point:

39.5 °C

Flash Point:

-26ºC

Refractive Index:

1.269

Water Solubility:

Hydrolysis

Storage Conditions:

2-8ºC

Vapor Pressure:

6.28 psi ( 20 °C)

Toxicity:

skn-rbt 500 mg/24H SEV 28ZPAK -,91,72

See More Trifluoroacetic anhydride Properties 

Hazard Identification

Classification of the substance or mixture

Skin corrosion, Sub-category 1A

Acute toxicity - Category 4, Inhalation

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 3

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H314 Causes severe skin burns and eye damage H332 Harmful if inhaled H412 Harmful to aquatic life with long lasting effects
Prevention	P260 Do not breathe dust/fume/gas/mist/vapours/spray. P264 Wash ... thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area. P273 Avoid release to the environment.
Response	P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P363 Wash contaminated clothing before reuse. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P316 Get emergency medical help immediately. P321 Specific treatment (see ... on this label). P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P317 Get medical help.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Trifluoroacetic anhydride Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

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We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
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Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

4 Inquiries

Country	Product	Purchase Quantity	Date Posted
India	Trifluoroacetic Anhydride	10.00 KG	Aug 8, 2025
India	Trifluoroacetic anhydride	500 KG	Apr 30, 2025
Russia	Trifluoroacetic anhydride	50 KG	Aug 1, 2023
Russia	Trifluoroacetic acid anhydride	30 KG	Jun 23, 2023

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