Pramiracetam High Purity Nootropic Agent CAS 68497-62-1 research use

Pramiracetam (CAS 68497-62-1), also known as CI-879 free base, is a pyrrolidone-derived nootropic agent and a potent cognitive enhancer. It was developed by Parke-Davis pharmaceutical company as a structural analogue of Piracetam, with significantly improved potency and efficacy .

Mechanism of Action:

Pramiracetam functions as a prolyl endopeptidase (PREP) inhibitor. It has been shown to improve cognitive impairment caused by traumatic brain injury and is being studied for potential applications in neurodegenerative diseases . As a cerebral metabolism-improving drug, it enhances brain function, promotes mental alertness, and improves memory consolidation.

Potency Comparison:

Clinical studies have demonstrated that Pramiracetam exhibits superior activity compared to other nootropic agents in its class. Its cognitive-enhancing activity is:

• 6 to 13 times more potent than Piracetam

• 3 to 4 times more potent than Oxiracetam

• 1.25 times more potent than Aniracetam 

Clinical Applications:

• Cognitive Impairment: Used for attention and memory disorders in the elderly

• Age-Related Cognitive Decline: Treatment of benign forgetfulness associated with aging

• Alzheimer's Disease: Prevention and symptomatic treatment of senile dementia (Alzheimer-type)

• Traumatic Brain Injury: Improves cognitive deficits associated with brain injuries 

• Vascular Cognitive Disorders: Effective in treating cognitive disorders of cerebrovascular origin

Key Features:

• High Purity: ≥ 98% (HPLC and titration), meeting rigorous quality standards 

• Low Toxicity: Well-tolerated with favorable safety profile 

• Long-Term Use: Suitable for chronic administration for symptom improvement 

• High Bioavailability: Soluble in water and methanol for versatile research applications 

Applications:

• Pharmaceutical R&D: As a high-quality API for nootropic drug development and formulation research

• Analytical R&D: Serves as a reference standard for quality control (QC), analytical method development and validation (AMV)

• Neuroscience Research: Used in studies on cognition, memory enhancement, and neurodegenerative disease mechanisms

• Aging Research: Investigated for its potential to delay cognitive decline associated with aging

Packaging: ___ (e.g.: 1g, 5g, 10g, 25kg per package, as per customer's request)

Storage: Store in a cool, dry, well-ventilated area, away from direct sunlight and moisture. Recommended storage temperature: 2-8°C (Refrigerator) . For long-term storage, keep sealed in a dry place at room temperature

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