SS-31 Peptide CAS 736992-21-5 Mitochondria-Targeting Tetrapeptide Elamipretide Research Grade Powder

1. Product Overview

SS-31, also known as Elamipretide, is a synthetic mitochondria-targeting tetrapeptide widely used in biomedical and cellular research.

It is designed to selectively target mitochondrial inner membranes and interact with cardiolipin, a key phospholipid involved in maintaining mitochondrial structure and function.

SS-31 is supplied as a high-purity lyophilized peptide powder intended strictly for laboratory research use only (RUO).

2. Basic Product Information

• Product Name: SS-31 (Elamipretide)
• CAS Number: 160367-95-1
• Molecular Type: Synthetic tetrapeptide
• Sequence: D-Arg-Dmt-Lys-Phe-NH2
• Appearance: White to off-white lyophilized powder
• Purity: ≥98% (HPLC verified)
• Grade: Research Grade (RUO)
• Form: Freeze-dried powder in vial
• Solubility: Water soluble (sterile buffer recommended)
• Storage Temperature: -20°C recommended
• Shelf Life: 24–36 months under proper storage conditions
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3. Molecular Characteristics & Structure

SS-31 is a short cell-permeable tetrapeptide engineered to accumulate in mitochondria and interact with mitochondrial membranes.

Its structure allows:

• Efficient cellular uptake
• Mitochondrial targeting
• Cardiolipin binding interaction
• Membrane stabilization under oxidative stress conditions

The peptide contains positively charged and aromatic residues that support strong affinity toward negatively charged mitochondrial membrane phospholipids.

4. Mechanism of Research Interest

SS-31 has attracted significant scientific attention due to its unique mitochondrial targeting ability.

4.1 Cardiolipin Interaction

SS-31 selectively binds to cardiolipin, a phospholipid essential for maintaining mitochondrial membrane integrity and function.

4.2 Mitochondrial Energy Regulation

Research suggests SS-31 may improve mitochondrial electron transport chain efficiency and reduce electron leakage.

4.3 Oxidative Stress Modulation

SS-31 is studied for its potential to reduce reactive oxygen species (ROS) production and oxidative damage in cells.

4.4 Cellular Protection Mechanisms

It is investigated in models involving:

• Hypoxia stress
• Ischemia-reperfusion injury
• Cellular aging processes

4.5 Bioenergetic Stability

SS-31 may help stabilize ATP production efficiency in stressed or dysfunctional mitochondria.

5. Research Applications

SS-31 is widely used in scientific research across multiple disciplines:

5.1 Mitochondrial Research

• Mitochondrial dysfunction studies
• Bioenergetics analysis
• Electron transport chain research

5.2 Cardiovascular Research

• Ischemia-reperfusion injury models
• Heart failure mechanism studies
• Cardiac energy metabolism research

5.3 Neurobiology Research

• Neurodegenerative disease models
• Brain mitochondrial function studies
• Oxidative stress in neurons

5.4 Aging & Longevity Studies

• Cellular aging mechanisms
• Mitochondrial aging pathways
• Anti-oxidative stress research

5.5 Pharmaceutical R&D

• Mitochondria-targeted drug development
• Peptide-based therapeutic research
• Cellular protection compound screening

6. Product Advantages

• High purity ≥98% (HPLC tested)
• Strict quality control system
• Stable lyophilized formulation
• Excellent batch-to-batch consistency
• Low impurity and endotoxin control
• Fast global shipping support
• Custom OEM/private label available

7. Manufacturing & Quality Control

All SS-31 batches are produced under controlled laboratory conditions with strict quality assurance protocols.

Quality testing includes:

• HPLC purity analysis
• Mass spectrometry confirmation
• Peptide sequence verification
• Moisture content testing
• Microbial limit testing

Each batch is supported with full documentation including COA, MSDS, and TDS.

8. Packaging & Supply Format

Standard packaging options:

• 1mg / vial
• 5mg / vial
• 10mg / vial
• 50mg / vial (bulk supply)
• 100mg / vial (custom order available)

Packaging details:

• Sterile glass vial (lyophilized powder)
• Sealed aluminum crimp cap
• Vacuum-sealed protective packaging
• Optional OEM labeling service
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9. Storage & Stability

To maintain stability and integrity:

• Store at -20°C for long-term storage
• Keep sealed and protected from light
• Avoid repeated freeze-thaw cycles
• Use sterile handling techniques

Under recommended conditions, SS-31 maintains stability for 24–36 months.

10. Shipping & Logistics

We provide reliable international shipping solutions for research customers:

• Express delivery: DHL / FedEx / UPS
• Temperature-controlled shipping available
• Dry ice packaging on request
• Discreet and secure packaging
• Fast dispatch within 24–72 hours for in-stock items
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