N-(5-Bromopyridin-2-yl)methanesulfonamide CAS 89466-22-8 95%+ Purity White to Off-White Solid Organic Synthesis Intermediate

1. Product Overview

N-(5-Bromopyridin-2-yl)methanesulfonamide (CAS No. 89466-22-8) is a high-quality brominated pyridine sulfonamide derivative, supplied with a minimum purity of 95%. This white to off-white crystalline solid is a versatile building block widely used in pharmaceutical intermediate synthesis, medicinal chemistry research, and advanced organic synthesis. With its unique combination of a reactive bromine atom at the C5 position and a methanesulfonamide group at the C2 position, it offers excellent utility in cross-coupling reactions and as a precursor for biologically active compounds.

2. Key Features and Advantages

• High Purity Guaranteed — Minimum 95% purity (HPLC verified), ensuring reliable and reproducible results in sensitive applications.

• Excellent Reactivity — The C5 bromine atom serves as an ideal handle for palladium-catalyzed cross-coupling reactions (Suzuki, Sonogashira, Buchwald-Hartwig), enabling efficient structural diversification.

• Versatile Synthetic Intermediate — The methanesulfonamide moiety provides a hydrogen-bonding capable functional group, valuable for target binding in drug discovery programs.

• Stable Solid Form — White to off-white solid with good shelf stability under recommended storage conditions, minimizing decomposition and ensuring long-term usability.

• Strict Quality Control — Each batch is tested by HPLC, NMR, and other analytical methods to ensure consistency and compliance with international standards.

3. Main Applications

• Pharmaceutical Intermediate — Serves as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of TRPV1 antagonists and other therapeutic agents targeting specific biological pathways.

• Medicinal Chemistry Research — Used as a scaffold for structure-activity relationship (SAR) studies and fragment-based drug discovery, enabling researchers to explore chemical space around the bromopyridine core.

• Organic Synthesis — Acts as a versatile building block for constructing complex heterocyclic molecules through palladium-catalyzed coupling reactions and other transformations.

• Materials Science — The pyridine nitrogen can coordinate with metal ions, making it a potential organic linker for metal-organic frameworks (MOFs) and coordination polymers with applications in gas storage, catalysis, and sensing.

4. Technical Specifications

5. Storage and Handling

• Storage Temperature — Store at 2–8°C in a cool, dry place. For long-term storage, keep in a sealed container under an inert atmosphere to prevent moisture absorption and degradation.

• Packaging Options — Available in various quantities including 100 mg, 250 mg, 500 mg, 1 g, 5 g, and bulk sizes upon request.

• Handling Precautions — Use standard laboratory personal protective equipment (PPE), including safety glasses, gloves, and a lab coat. Avoid generating dust or aerosols. Use in a well-ventilated area or fume hood.

• Shelf Life — When stored as recommended, the product maintains its specified purity for at least 2 years from the date of manufacture.

6. Safety Overview

• Hazard Classification — This product is not classified as a hazardous substance under standard GHS criteria. However, it is intended for research and industrial use only, not for direct human consumption or therapeutic use.

• First Aid Measures — In case of skin contact, wash immediately with plenty of soap and water. In case of eye contact, rinse thoroughly with water for at least 15 minutes and seek medical attention. If inhaled, move to fresh air. If ingested, do not induce vomiting — seek medical advice immediately.

• Firefighting Measures — Use water spray, carbon dioxide, dry chemical, or foam extinguishers. The product is combustible; avoid open flames and high heat.

• Disposal Considerations — Dispose of in accordance with local, regional, and national regulations for chemical waste. Do not discharge into drains or the environment without proper treatment.