4-Bromo-2-ethyl-6-methylbenzaldehyde CAS 2706490-14-2 98% Purity Organic Synthesis Intermediate

1. Product Overview

4-Bromo-2-ethyl-6-methylbenzaldehyde (CAS: 2706490-14-2) is a brominated aromatic aldehyde derivative serving as a key building block in organic synthesis, pharmaceutical R&D, and agrochemical development. With the molecular formula C₁₀H₁₁BrO and a molecular weight of 227.10 g/mol, it features a benzaldehyde core substituted with bromine at the 4-position, ethyl at 2-, and methyl at 6-position. Supplied at 98% minimum purity, this compound offers versatile reactivity through its aldehyde group (oxidation, reduction, condensation) and aryl bromide moiety (cross-coupling reactions), making it valuable for constructing complex molecular scaffolds.

2. Key Features and Advantages

• High Purity: ≥98% assay ensures reliable performance in multi-step syntheses and sensitive condensation/coupling protocols.

• Dual Functional Groups: Aldehyde enables Wittig, aldol, reduction to alcohol or oxidation to acid; aryl bromide supports Suzuki, Sonogashira, and Buchwald–Hartwig couplings.

• Defined Substitution Pattern: Fixed 2-ethyl-6-methyl arrangement minimizes isomer formation in downstream transformations.

• Stable Solid Form: Crystalline solid with good shelf life under recommended cool, dry storage.

• Consistent Quality: Each batch is accompanied by CoA and analytical verification (NMR, HPLC).

3. Main Applications

• Pharmaceutical Intermediates: Used in API scaffold assembly via aldehyde functionalization and aryl–aryl bond formation.

• Agrochemical Building Block: Precursor for herbicides, fungicides, and crop-protection agents.

• Fine Chemical Synthesis: Intermediate for dyes, ligands, and functional materials.

• Academic Research: Employed in method development for aldehyde chemistry and palladium-catalyzed cross-couplings.

• Custom Synthesis: Suitable for scale-up from milligram screening to pilot/batch production.

4. Technical Specifications

5. Storage and Handling

• Store in a cool, dry place away from direct sunlight and moisture. For long-term stability, keep at 2–8 °C in a tightly sealed container; inert atmosphere (N₂/Ar) is recommended if stored for extended periods.

• Handle in a well-ventilated area or fume hood to avoid inhalation of dust or vapors.

• Use personal protective equipment: nitrile gloves, safety goggles, and lab coat.

• Avoid contact with strong oxidizers, strong acids/bases, and amines unless intended for controlled reaction.

• Keep container tightly closed when not in use. Follow standard laboratory hygiene practices.

6. Safety Overview

This compound is an aromatic aldehyde and halogenated arene; treat as potentially hazardous:

• Health Hazards: May cause skin irritation, serious eye irritation, and respiratory discomfort. Aldehydes can be sensitizing; handle with care.

• Environmental Precautions: Do not discharge into drains or waterways. Collect spillage and dispose of as hazardous chemical waste per local regulations.

• First Aid Measures:

• Skin Contact: Wash immediately with plenty of soap and water.

• Eye Contact: Rinse cautiously with water for several minutes; remove contact lenses if present; seek medical advice.

• Inhalation: Move to fresh air; if breathing difficulty occurs, administer oxygen and consult a physician.

• Ingestion: Rinse mouth; do NOT induce vomiting; seek immediate medical attention.

• Regulatory Note: For research and industrial use only, not for human or veterinary therapeutic use. SDS available upon request.