3-(6,7-dichloro-1H-indol-2-yl)propanoic acid methyl ester | CAS 3022403-95-5 | 98% | Dichloro indole derivative, fine chemical, pharmaceutical interme

1. Product Overview

3-(6,7-dichloro-1H-indol-2-yl)propanoic acid methyl ester (CAS 3022403-95-5) is a dichloro-substituted indole derivative with the molecular formula C₁₂H₁₁Cl₂NO₂ and a molecular weight of 272.13. Structurally, it consists of a 6,7-dichloro-1H-indole core connected at the 2-position to a propanoic acid methyl ester side chain. Supplied as a high-purity research-grade fine chemical, this compound is intended exclusively for industrial applications, scientific research, and organic synthesis. It is not for human or veterinary use, nor for clinical diagnostic or therapeutic applications.

2. Key Features and Advantages

• Defined Scaffold: The dichloroindole structure serves as a versatile building block for complex heterocyclic synthesis.

• High Purity: Consistently maintained at ≥98% purity (HPLC/GC), ensuring reliability in sensitive reactions.

• Analytical Support: Comprehensive Certificates of Analysis (CoA) and spectral data (NMR, MS) are available upon request.

• Scalable Supply: Available in quantities ranging from milligrams for R&D to kilograms for pilot-scale production.

• Chemical Stability: The methyl ester group offers stability during storage while remaining reactive for hydrolysis or coupling reactions.

3. Main Applications

• Pharmaceutical Intermediates: Utilized in the synthesis of novel indole-based APIs targeting various therapeutic areas.

• Medicinal Chemistry: Acts as a key intermediate in the development of kinase inhibitors and GPCR modulators.

• Organic Synthesis: Employed in academic and industrial labs for constructing diverse indole-containing libraries.

• Process Research: Serves as a reference standard for method validation and process optimization in fine chemical manufacturing.

4. Technical Specifications

5. Storage and Handling

Store in a tightly sealed container in a cool, dry, and well-ventilated area, protected from moisture, light, and incompatible substances (strong oxidizers, strong bases). For long-term stability, refrigeration at 2–8°C is recommended; short-term storage at ambient temperature (15–25°C) is acceptable under anhydrous conditions. Handle in a fume hood to avoid dust generation. Use appropriate personal protective equipment (PPE), including safety goggles, nitrile gloves, and a lab coat. Wash hands thoroughly after handling. Dispose of waste in accordance with local environmental regulations for halogenated organic waste.

6. Safety Overview

This product is for research and industrial use only—not for human or animal consumption. While specific toxicological data is limited, it should be handled as a potentially hazardous fine chemical. May cause skin, eye, and respiratory irritation. Avoid inhalation of dust and contact with skin or eyes. In case of eye contact, rinse immediately with plenty of water for several minutes. If inhaled, move the affected person to fresh air. If swallowed, rinse mouth and seek medical attention. Always consult the accompanying Safety Data Sheet (SDS) for comprehensive safety instructions and emergency procedures.