AOD 99% High peptide | White Powder 99.0% High Purity MOST-C RETA SEMA ghk cu

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  AOD-9604 (commonly abbreviated as AOD) is a synthetic hexadecapeptide corresponding to amino acid residues 177–191 of human growth hormone, modified with an N‑terminal tyrosine residue to enhance structural stability. Its sequence is Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe, stabilized by an intramolecular disulfide linkage. With a molecular formula of C₇₈H₁₂₃N₂₃O₂₃S₂ and a molecular weight of approximately 1815 Da, it is produced via solid-phase peptide synthesis and supplied as a high-purity lyophilized powder intended strictly for laboratory research.

  
  

  Mechanism of Action:​

  AOD-9604 operates independently of the full growth hormone receptor (GHR) and its downstream signaling cascades. It exerts its primary effects on adipose tissue by modulating adrenergic signaling pathways, specifically upregulating cyclic adenosine monophosphate (cAMP) levels within adipocytes. This process enhances the activity of key metabolic enzymes responsible for triglyceride breakdown while concurrently suppressing pathways involved in new fatty acid synthesis, thereby selectively mimicking the lipid-mobilizing domain of human growth hormone without influencing systemic growth factor levels.

  
  

  Research Advantages:​

  This compound provides a distinct advantage for metabolic research by isolating the lipolytic functionality of the growth hormone molecule from its anabolic and systemic endocrine effects. Its adipose-selective action allows investigators to study fat metabolism, energy expenditure, and receptor sensitivity in models of obesity or metabolic dysregulation without the confounding variables associated with elevated serum growth factors or impaired glucose homeostasis, making it a precise tool for elucidating metabolic regulatory networks.

  
  

  Intended Research Population:​

  AOD-9604 is designated for non-clinical, in vitro, and in vivo investigations involving adipocyte biology, obesity models, lipid metabolism assays, and studies on age-related metabolic decline. It is also utilized in musculoskeletal research exploring cartilage matrix synthesis and joint health. It remains an investigational reference reagent restricted to qualified scientific environments and is not approved for therapeutic, diagnostic, or human/animal administration outside controlled experimental protocols.

  
  

  
  

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