alpha-Ketoglutarate acid Powder ; Ca-AKG Powder;AKG99%

High purity Calcium alpha-Ketoglutarate powder 99%

Calcium alpha-ketoglutarate (Calcium Alpha-Ketoglutarate, abbreviated as CA-AKG or Ca-AKG) is the calcium salt form of alpha-ketoglutarate (AKG), with the chemical formula C8H12O4Ca. It appears as a white to off-white crystalline powder.

1. Core Components and Mechanism of Action  of α-Ketoglutarate (AKG)

·α-Ketoglutarate (AKG): A key intermediate metabolite in the tricarboxylic acid (TCA) cycle, involved in cellular energy (ATP) production, amino acid metabolism, and epigenetic regulation. It is a core node connecting carbon–nitrogen metabolism.  

·Calcium ions: After binding with AKG, they not only compensate for the poor stability, easy degradation, and low absorption of free AKG, but also achieve a synergistic effect between calcium and AKG, improving bioavailability.  

2. Main Effects and Functions  of Calcium Alpha-Ketoglutarate

·Anti-aging and lifespan extension: By improving mitochondrial function, reducing cellular oxidative damage, and regulating epigenetics (e.g., influencing DNA methylation), it helps delay aging. Some studies suggest it may contribute to extending lifespan and improving healthspan.  

·Metabolism improvement and vitality enhancement: Promotes energy metabolism and relieves fatigue; supports nitrogen metabolism, helping remove excess ammonia from the body and reducing liver burden; improves insulin sensitivity and metabolic health.  

·Bone and gut health support: Promotes osteoblast proliferation, improves bone density, and helps prevent bone loss; provides energy for intestinal epithelial cells, maintains gut barrier function, and improves intestinal health.  

·Sports nutrition and physical performance: Promotes protein synthesis, reduces muscle breakdown, enhances muscle strength and endurance, and supports faster post-exercise recovery.  

·Other supportive effects: Has certain antioxidant and anti-inflammatory properties, and may support cardiovascular health, neurological health (e.g., cognitive function), and skin health (e.g., promoting collagen production).  

3. Main Application Areas  of AKG

·Dietary supplements and functional foods: As a core ingredient in anti-aging, sports nutrition, and metabolic health supplements (e.g., anti-aging products, pre-workout supplements). Due to its good stability and high absorption, it is a mainstream form in the health industry.  

·Pharmaceutical and animal health: Used as a pharmaceutical intermediate or adjunct therapeutic agent for improving metabolic diseases and related conditions; in animal health, it is used to promote growth and enhance immunity.