raw material Inositol niacinate

Inositol niacinate More Info

Product Overview

Inositol Niacinate (also known as Inositol Nicotinate or Inositol Hexanicotinate) is a dietary supplement form of niacin (vitamin B3) and an effective vasodilator. This compound is composed of six molecules of nicotinic acid bonded to one molecule of myo-inositol, with a molecular formula of C₄₂H₃₀N₆O₁₂ and a molecular weight of 810.72 g/mol. Also known as "no-flush niacin," it offers the benefits of niacin without the uncomfortable skin-flushing side effects associated with high-dose crystalline niacin.

Key Benefits

Inositol niacinate provides several potential health benefits. This supplement helps lower total cholesterol, LDL cholesterol, VLDL, and triglyceride levels while raising HDL (antioxidative) cholesterol levels. It promotes peripheral vasodilation and improves circulation in individuals with poor blood flow conditions. Niacin is involved in metabolic processes including carbohydrate and fat breakdown, supporting normal energy metabolism. The product also contributes to proper nervous system function and psychological wellbeingand helps maintain healthy skin and mucous membranes.

Mechanism of Action

When ingested, inositol nicotinate is absorbed intact and hydrolyzed in the body, releasing free niacin and inositol. The released niacin helps regulate blood lipid levels and supports cellular metabolism through coenzymes NAD and NADP. The compound binds six molecules of nicotinic acid to one inositol molecule, creating a stable, slow-release form that reduces the likelihood of flushing responses.

Product Specifications

This supplement typically comes in tablet or capsule form. Common dosages include 500 mg or 750 mg per tablet. Each tablet typically contains approximately 505 mg of niacin (as inositol hexaniacinate) and 115 mg of inositol. The CAS number for this compound is 6556-11-2. Products should be stored in cool, dry places away from direct light.

Suggested Use

The general suggested dosage is one to three tablets daily with meals, or as directed by a healthcare professional. For specific therapeutic conditions such as Raynaud's phenomenon or intermittent claudication, dosages up to 4 g daily may be used under medical supervision.

Safety Profile

Inositol nicotinate is generally safe for most people. Common side effects may include mild stomach upset, intestinal gas, nausea, and mild itching. No serious adverse side effects have been commonly reported. However, users should exercise caution and consult healthcare providers if they have liver abnormalities, bleeding disorders, stomach ulcers, or diabetes. Long-term use may increase blood glucose levels, potentially affecting hypoglycemic medications. When combined with statin medications, there may be an increased risk of muscle-related issues.

Applications

This supplement has been used in Europe for over 30 years for various purposes. It helps lower cholesterol levelsand improves blood flow. It is commonly used for treating intermittent claudication, which is calf muscle pain during walking due to reduced oxygen supply. Other applications include managing Raynaud's phenomenon, which is a painful response to cold exposure affecting hands or feet, supporting diabetes management adjunct therapy, and cardiovascular health maintenance.

Important Notes

Keep this product out of reach of children. Consult a healthcare professional before use during pregnancy or breastfeeding. Avoid alcohol consumption while using this supplement. This product should not replace professional medical advice or treatment. Products should be manufactured in GMP-certified facilities to ensure quality standards.