High Quality Raw Material Product CAS 21679-14 1 Bulk 99% Fludarabin Powder

The chemical name of fludarabin is 9-1 β D-arabifurose-2-fluoroadenosine is an anti-tumor drug. Fludarabin is an anti metabolic fluoropurine nucleoside analogue with high selectivity towards lymphocytes. It can inhibit the repair of DNA in quiescent Chemicalbook cells and the synthesis of DNA in dividing cells. It also promotes apoptosis in these cells and has shown good therapeutic effects. Currently, it is widely used in the treatment of various hematological diseases, especially chronic B-lymphocytic leukemia.

Function

This drug is a fluorinated nucleotide analogue of adenosine arabinose, which can relatively resist the deamination effect of adenosine deaminase. Fludarabin phosphate is rapidly deated to form 2F ara-A, which can be taken up by cells and then lated by intracellular deoxycytidine kinase to form the active triphosphate chemicalbook salt 2F ara-ATP. This metabolite can be produced by inhibiting nucleotide reductase and DNA polymerase( α,δ and ε), DNA primers and DNA ligases inhibit DNA synthesis. In addition, it can partially inhibit RNA polymerase II, thereby reducing protein synthesis.

Application
Its phosphate group is rapidly cleaved in the bloodstream, and the remaining 2-fluoroadenosine (Fara-A) enters the cells and islated into the active metabolite Farar ATP, exerting its effects. Used for chronic lymphocytic leukemia.

Xi’an Fulecare biotech has high-technique enterprises with 10 years history,dedicate to separation, purification of the natural active ingredients production and sales.

We also produce international frontier dietary supplements such as granulated powder,solid drinks,tea sachets, capsules and tablets etc.

We have high grade clean workshop,800 square meters of inspection center equipped with more than 10 sets of HPLC,GC,IR,MASS instruments,these provides a full range of quality assurance to our products

The company has a perfect quality assurance system.We implement strict quality control standards and have passed the certification for the ISO9001 Quality Management System. The Quality Management Department is equipped with many sets of high performance liquid chromatography (HPLC)instruments, ultraviolet spectrophotometers (UV), several spectropolarimeters, a gas chromatograph (GC), melting point apparatus, and other advanced testing and experimental equipment. We make a detailed division of labor for technology research, and for quality assurance and quality control, so that we can conduct effective and comprehensive quality control in the production process. This also allows us to make comprehensive detection analysis of final products, thus ensuring products quality.