Complete Ultra-Detailed Product Data – 2-Nitrobenzoic acid CAS 88-95-9

1. Basic Identification

2. Physical & Chemical Properties

Appearance

Core Physical Constants

Key Chemical Characteristics

1. Dual functional groups: ortho-position nitro group + carboxylic acid group, dual reactive sites for multi-step synthesis.
2. Carboxyl reactivity: Reacts with alcohols for esterification; reacts with amines to form amides; neutralizes with alkalis to produce soluble o-nitrobenzoate salts (sodium o-nitrobenzoate).
3. Nitro group reduction: Catalytic hydrogenation / iron powder-acid reduction converts -NO₂ to -NH₂ to generate 2-aminobenzoic acid (anthranilic acid), a core high-value downstream intermediate.
4. Thermal property: Decarboxylation occurs above 220 ℃ to form nitrobenzene; decomposes under strong heating, releasing toxic nitrogen oxide fumes.
5. Incompatibility: Reacts violently with strong oxidants, strong reducing agents, strong bases; avoid mixing with alkaline raw materials, metal powders, combustibles.
6. Weak light sensitivity: Long-term sunlight exposure leads to darkening, needs light-proof sealed storage.

3. Export Industrial Quality Specifications

Premium Industrial Grade (GC ≥99.0%, mainstream export)

Pharma High-Purity Grade (HPLC ≥99.5%)

• Single isomer impurity ≤0.1%, heavy metal <1 ppm, low ash content, low insoluble matter, for high-end API and peptide coupling synthesis.

4. Main Industrial Applications

4.1 Pharmaceutical Intermediate (Core High-value Application)

1. Precursor of anthranilic acid (2-aminobenzoic acid): After nitro reduction, anthranilic acid is raw material for cardiovascular drugs, anti-inflammatory drugs, anti-tumor heterocyclic APIs, quinoline antibacterial agents.
2. Synthesis of pharmaceutical esters and amides: Ortho-nitrobenzoyl protecting group reagent for amino acid & solid-phase peptide synthesis, used for side chain temporary blocking in multi-step peptide coupling.
3. Raw material for local anesthetics, antipyretic analgesics, vitamin derivatives.

4.2 Dye & Pigment Intermediate

1. Manufacture of azo acid dyes, mordant dyes, disperse dyes; ortho nitro group improves dye color fastness and color depth.
2. Synthesis of fluorescent whitening agents and organic pigment color couplers for textile printing and paper coloring.

4.3 Agrochemical Intermediate

1. Raw material for herbicides, fungicides and plant growth regulators; ortho-nitrobenzamide derivatives have bacteriostatic activity against crop pathogenic fungi.
2. Chelating auxiliary intermediate for pesticide formulation.

4.4 Laboratory Analytical Reagent

1. Standard acidimetric reference substance for pH calibration and acid-base titration calibration.
2. Organic synthesis substrate for research of nitro group reduction, esterification, decarboxylation reaction mechanism.

4.5 Other Fine Chemical Uses

1. Corrosion inhibitor auxiliary for metal surface treatment;
2. Raw material for photosensitive materials and chemical developer additives.

5. Safety, Packaging, Storage & Transportation

GHS Hazard Classification

• Skin Irritation Category 2
• Serious Eye Damage Category 1
• Chronic Aquatic Toxicity Category 4
  
  
  Signal Word: Warning
  
  
  Hazard Statements:
  
  
  H315 Causes skin irritation
  
  
  H318 Causes serious eye damage
  
  
  H413 May cause long lasting harmful effects to aquatic life

Export Standard Packaging

1. Industrial bulk crystal: 25kg inner plastic liner + outer PP woven bag; 25kg light-proof lined iron drum for long sea transportation
2. Pharma high-purity grade: Vacuum aluminum foil inner bag + iron drum, moisture & light isolation
3. Small trial package: 1kg / 5kg sealed plastic can

Storage Requirements

1. Store in cool, dry, well-ventilated general chemical warehouse, temperature ≤30 ℃, light-proof, sealed tightly to prevent moisture absorption and discoloration.
2. Separated storage away from strong oxidants, strong reducing agents, strong alkalis, food raw materials and feed.
3. Warehouse equipped with dust-proof ventilation, dust masks, acid-resistant gloves and emergency eyewash station.
4. Shelf life: 12 months under dry light-proof sealed storage; re-test purity if expired.

Transportation Regulation

• Waterproof and light-proof during transit, avoid rain and long-term sunlight exposure to prevent crystal caking and discoloration.
• Forbid mixed loading with oxidants, alkaline chemicals, edible raw materials.
• Complete export documents supplied: COA, MSDS, TDS, marine dangerous goods declaration, REACH test report.

6. E-commerce Listing Copy (Direct Copy for Alibaba/Echemi)

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7. Export COA Print Template

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