—— Product Specifications ——

—— Product Detail ——

• • • • • • • • • • • • • • • • • • • • • • • Product Overview

                                              2-Chloro-4-methylsulfonylbenzoic acid is an aromatic carboxylic acid derivative with the molecular formula C₈H₇ClO₄S and a molecular weight of 234.66 g/mol. This white to off-white crystalline powder features a benzoic acid core substituted with chlorine at the 2-position and a methylsulfonyl group at the 4-position, providing a valuable building block for pharmaceutical synthesis. The compound's combination of a carboxylic acid, a chlorine atom, and a sulfone group offers multiple sites for chemical modification, making it an important intermediate in the synthesis of various drug candidates.

                                              Synthetic Process

                                              2-Chloro-4-methylsulfonylbenzoic acid is synthesized through the following routes:

                                              • Oxidation of 2-chloro-4-methylthiobenzoic acid: The methylthio derivative is oxidized using an oxidizing agent to form the methylsulfonyl group.

                                              • Purification: The crude product is purified by recrystallization from appropriate solvents.

                                              Mechanism of Action / Application Principles

                                              • Pharmaceutical Synthesis: Used as a building block for the synthesis of various drug candidates, including enzyme inhibitors and receptor modulators.

                                              • Organic Synthesis: The carboxylic acid enables derivatization to esters, amides, and other functional groups.

                                              • Sulfone Chemistry: The methylsulfonyl group provides unique electronic and polar properties.

                                              Quality Specifications

                                              
                                              

                                              
                                              

                                              Parameter	Specification
                                              Assay	≥98.0%
                                              Appearance	White to off-white crystalline powder
                                              Melting Point	220 - 224°C (dec.)
                                              Loss on Drying	≤0.5%
                                              Residue on Ignition	≤0.1%

                                              Each batch is accompanied by a Certificate of Analysis (COA).

                                              Packaging & Storage

                                              • Research quantities: 1g, 5g HDPE bottles

                                              • Bulk quantities: 25g, 100g HDPE containers

                                              Storage conditions: Store in a cool, dry place in tightly sealed containers, protected from light. Under recommended conditions, shelf life is 36 months.

                                              
                                              

— C ompany Profile ——

Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.

Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.

We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.

To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.

Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers.

—— Q&A ——

Q1: How to confirm the product quality before placing orders?
A: By sending you available samples. Or if you have special requirements for the goods, we can prepare samples according to your requirements for confirmation.

Q2: Can you supply free samples?
A: Yes, we can provide a free sample, but the shipping cost will be paid by the customers. You can either pay the shipping cost or arrange a courier to collect the samples.

Q3: How do you treat quality complaints?
A: All our products are strictly tested by our QC and confirmed by QA; unqualified material will not be released to customers. If any quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately.

Q4: What is your MOQ? Is there a discount?
A: For highvalue products, our MOQ starts from 1g and generally starts from 10g. For other lowprice products, our MOQ starts from 100g and 1kg.
Q: Is there a discount?
A: Yes, for larger quantities, we always support with better prices.

Q5: How to start orders or make payments?
A: You can send us your Purchase Order (if your company has one), or just send a simple confirmation by email or via Trade Manager. We will then send you a Proforma Invoice with our bank details for your confirmation, and you can make payment accordingly. If you have other preferred payment methods, we are open to discussion and negotiation.