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Pyrrolidine 123-75-1 Industrial Grade

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Unit Price:

$45-56/MT FOB

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CAS No.:

123-75-1

Grade:

Industrial Grade

Content:

99%

Port:

Brand:

orient

Packaging:

1KG, 5KG, 25KG

Price valid (until):

2028-01-19

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

Qualification:

Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
Seller Information
Inquiry History

Description

Product Name:	Dermorphin
Synonyms:	DERMORPHIN ACETATE;L-Tyr-D-Ala-L-Phe-Gly-L-Tyr-L-Pro-L-Ser-NH2;Tyrosyl-alanyl-phenylalanyl-glycyl-tyrosyl-prolyl-serinamide;Dermorphin trifluoroacetate salt;Dermorphin Powder;(2S)-N-[(2S)-1-amino-3-hydroxy-1-oxopropan-2-yl]-1-[(2S)-2-[[2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-3-phenylpropanoyl]amino]acetyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carboxamide;Dermorphin HAc;(2S)-1-[(2S)-2-[[2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-3-phenyl-propanoyl]amino]acetyl]amino]-3-(4-hydroxyphenyl)propanoyl]-N-[(1S)-1-carbamoyl-2-hydro
CAS:	77614-16-5
MF:	C40H50N8O10
MW:	802.87
EINECS:	202-853-6
Product Categories:	77614-16-5
Mol File:	77614-16-5.mol

Dermorphin Chemical Properties

Melting point	157-159 °C
Boiling point	1323.8±65.0 °C(Predicted)
density	1.363±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	Soluble in DMSO
form	powder
pka	9.83±0.15(Predicted)
color	white to off-white
Sequence	H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2
InChIKey	FHZPGIUBXYVUOY-VWGYHWLBSA-N
SMILES	C(N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N)(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](C)NC(=O)[C@@H](N)CC1C=CC(O)=CC=1)CC1C=CC=CC=1)CC1C=CC(O)=CC=1

Safety Information

WGK Germany

MSDS Information

Dermorphin Usage And Synthesis

Structure	Dermorphin does not contain the common N-terminal sequence for the traditional endogenous peptides (Tyr–Gly–Gly–Phe), and its sequence is completely different from those of the endomorphins, which were identified as endogenous μ- peptides that also do not contain the common sequence. Interestingly, DM contains D-alanine (a D-isomer amino acid) in its sequence. The primary structure of dermorphin is YDAFGYPS-NH2.
Description	Dermorphin was first isolated from the skin of the skin of South American frogs of the genus Phyllomedusa. It is a high potency natural opiate peptide that binds selectively to mu- receptors.
Uses	A mu- receptor agonist
Definition	ChEBI: Dermorphin is an oligopeptide.
Side effects	Like μ-opiate agonists, dermorphins produce antinociception and also catalepsy, respiratory depression, constipation, tolerance, and dependence, although at a lower degree than does[1].
in vitro	Dermorphin, a peptide isolated from the skin of Phyllomedusa frogs and the peptide receptor (NOP) component by the endogenous agonist nociceptin/orphanin FQ (N/OFQ). In displacement binding studies at CHOhMu, Dermorphin and DeNo displac the binding of [3H]-DPN in a concentration dependent and saturable manner. Dermorphin displays an affinity of 7.17, while N/OFQ fails to displace [3H]-DPN at the Delta receptor. Dermorphin and DeNo stimulate the binding of GTPγ[35S] in a concentration dependent and saturable manner at the Mu receptor.
References	[1] Negri, L. P. Melchiorri and R. Lattanzi. “ and Bv8 Peptides.”Handbook of Biologically Active Peptides (Second Edition) 2013:376-383.

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Q1:Do you provide sample?

A: Yes, we can provide free sample, you only need pay the shipping cost.

Q2: What is the lead time?

A: For stock goods, it usually take about 5-7 days by air, 15-30 days by sea,For customized products, the delivery time needs to be confirmed based on the actual situation.

Q3: How can I buy? What is the payment method?

A: You can contract us through Email or you can browse our website:orientchem.cc, we have bank transfer,

Q4:What if there are quality issues？

A：We attach great importance to after-sales service of our products. If there are any quality issues, please contact us within 30 days of receiving the goods and we will handle returns and exchanges for you.

Basic Info

Product Name:

Pyrrolidine

Other Name:

Pyrrolidine;Azacyclopentane;Prolamine;Pyrrole,tetrahydro-;Tetrahydropyrrole;Tetramethylenimine;Pyrrolidine ring;Butylenimine;Azolidine;Perhydropyrrole;NSC 62781;9: PN: WO2017048620 SEQID: 14 claimed sequence

CAS No.:

123-75-1

Molecular Formula:

C4H9N

InChIKeys:

InChIKey=RWRDLPDLKQPQOW-UHFFFAOYSA-N

Molecular Weight:

71.12

Exact Mass:

71.12

BRN:

102395

EC Number:

204-648-7

UNII:

LJU5627FYV

ICSC Number:

1315

NSC Number:

62781

UN Number:

1922

DSSTox ID:

DTXSID3059559

Color/Form:

Colorless to pale yellow liq

HScode:

2933990090

Categories:

Inhibitor Drugs

Characteristics

PSA:

XLogP3:

0.46

Appearance:

Liquid

Density:

0.8520 g/cm³ @ Temp: 22.5 °C

Melting Point:

57.69 °C

Boiling Point:

86.71 °C

Flash Point:

37 °F

Refractive Index:

1.428

Water Solubility:

Miscible with alcohol, ether, chloroform and water.

Storage Conditions:

Flammables area

Vapor Pressure:

128 mm Hg ( 39 °C)

Vapor Density:

2.45 (vs air)

Toxicity:

Oral-Rat LD50: 300 mg/kg; Oral-Mouse LD50: 450 mg/kg

Flammability characteristics:

It is flammable in case of open flame, high temperature and oxidant; produces toxic nitrogen oxide gas when heated

Explosive limit:

1.6-10.6%(V)

Odor:

Unpleasant, ammoniacal odor

Taste:

POWERFUL, AMMONIACAL TASTE

Henrys Law Constant:

2.39e-06 atm-m3/mole|Henry's Law constant = 2.39X10-6 atm-cu m/mol at 25 dec C

Dissociation Constants:

pK at 25 °C = 2.89|pKa = 11.31

Experimental Properties:

Hydroxyl radical reaction rate constant = 7.85X10-11 cu cm/molec-sec at 25 °C (est)

Air and Water Reactions:

Highly flammable. Very soluble in water.

Reactive Group:

Amines, Phosphines, and Pyridines

Reactivity Alerts:

Highly Flammable

Reactivity Profile:

PYRROLIDINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides. An explosion occurred when a mixture of pyrrolidine, benzaldehyde, and propionic acid was heated in an attempt to form porphyrins.

Heat of Combustion:

-673.75 Kcal/mol at 298 K and 1 atm

Flammable Limits:

LOWER: 2.9% @ -2 °C, UPPER 13.0% @ 29.8 °C

Physical Dangers:

The vapour is heavier than air and may travel along the ground; distant ignition possible.

Corrosivity:

Corrosive

Heat of Vaporization:

529 J/g at 0.1 MPa

Critical Temperature & Pressure:

Critical temperature: 568.55 K; Critical pressure: 5.6134X10+6 Pa

See More Pyrrolidine Properties 

Hazard Identification

Classification of the substance or mixture

Flammable liquids, Category 2

Acute toxicity - Category 4, Oral

Skin corrosion, Sub-category 1A

Serious eye damage, Category 1

Acute toxicity - Category 4, Inhalation

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H225 Highly flammable liquid and vapour H302 Harmful if swallowed H314 Causes severe skin burns and eye damage H332 Harmful if inhaled
Prevention	P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P233 Keep container tightly closed. P240 Ground and bond container and receiving equipment. P241 Use explosion-proof [electrical/ventilating/lighting/...] equipment. P242 Use non-sparking tools. P243 Take action to prevent static discharges. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P260 Do not breathe dust/fume/gas/mist/vapours/spray. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area.
Response	P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse affected areas with water [or shower]. P370+P378 In case of fire: Use ... to extinguish. P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth. P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P363 Wash contaminated clothing before reuse. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P316 Get emergency medical help immediately. P321 Specific treatment (see ... on this label). P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P305+P354+P338 IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P317 Get medical help.
Storage	P403+P235 Store in a well-ventilated place. Keep cool. P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

NO open flames, NO sparks and NO smoking. Closed system, ventilation, explosion-proof electrical equipment and lighting. Use non-sparking handtools. Prevent build-up of electrostatic charges (e.g., by grounding). Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Fireproof. Separated from strong oxidants and acids. Well closed.Bundling and sills should be provided to prevent spread of liquid accidentally escaping from storage and process vessels.

See More Pyrrolidine Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

A reliable supplier is like insurance.

We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
Integrity is the foundation, quality is life. We would like to work together with you to build a greener and brighter future.

Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

5 Inquiries

Country	Product	Purchase Quantity	Date Posted
Poland	Pyrrolidine	20 MT	Mar 12, 2025
Australia	pyrrolidine	1 KG	Mar 30, 2026
United Kingdom	Pyrrolidine	100 KG	Oct 14, 2024
Singapore	Pyrrolidine	2 KG	Jul 22, 2026
Mexico	Tetrahydropyrrole	10 KG	Sep 30, 2023

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