MS40 WDR5 PROTAC Research Sample Available in Multiple Specifications

Product Advantages

1. Potent Target Degradation Capacity

   
   

   Different from common competitive inhibitors, MS40 catalyzes sustained degradation of WDR5 protein without relying on continuous high-concentration administration. It markedly reduces intracellular WDR5 levels, inhibits H3K4 methylation, and blocks malignant transcription in tumor cells. Compared with VHL-recruiting WDR5 PROTAC (MS169), it exhibits obvious advantages in cellular activity and in vivo stability.
2. Strict Quality Control & Stable Batch Consistency

   
   

   Every batch undergoes full verification of structure and purity. Purity is tested via HPLC, while HRMS and NMR spectroscopy confirm molecular structure. Water content, residual organic solvents and impurity levels are inspected simultaneously to meet universal international standards for research reagents, ensuring repeatable experimental results across batches.
3. Compatibility with Multi-Level Research Models

   
   

   The compound presents favorable solubility in common organic solvents such as DMSO. It supports in vitro cellular assays including cell proliferation tests, western blot and co-immunoprecipitation for mechanism exploration. It is also applicable to in vivo pharmacodynamic evaluation using primary tumor cells and PDX animal models.
4. Extensive Literature Support

   
   

   MS40 has been cited in multiple high-impact academic publications. It is a well-recognized selective WDR5 degrader within the field, with abundant reference protocols available to facilitate rapid research setup.

Application Fields

Quality Control Standards

1. Purity Test: Reversed-phase RP-HPLC, total purity ≥99.0%, maximum single impurity ≤0.5%;
2. Structure Identification: ¹H NMR, ¹³C NMR and HRMS, fully consistent with target molecular structure;
3. Water Content Test: Karl Fischer titration, water content ≤0.5%;
4. Residual Solvents: Compliant with limits described in ICH Q3C guidelines, free of hazardous solvent residues;
5. Appearance Standard: Uniform white to off-white solid powder without caking or discoloration.

Storage, Transportation & Safety Instructions

1. Long-term storage for solid powder: Keep sealed, away from light and moisture at -20℃. For short-term storage at 4℃, finish usage within 6 months.
2. Transportation: Standard room-temperature delivery. Cold-chain transportation is available for bulk orders or pre-dissolved solutions.
3. Safety Notice: This product is for scientific laboratory research only. It cannot be used for clinical diagnosis, medical treatment, food or pharmaceutical production. Wear protective gloves, goggles and lab coats during operation. Avoid direct contact with skin and mucous membranes. Seal tightly after sampling to prevent moisture absorption and degradation.