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Dihydroergotoxine mesylate8067-24-1

Name: Dihydroergotoxine mesylate8067-24-1
Brand: OORENT
SKU: pr2608041691
Price: 33 USD
Availability: InStock

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CAS No.:

8067-24-1

Grade:

Pharmaceutical Grade

Content:

99%

Port:

shanghai

Brand:

OORENT

Packaging:

vial

Price valid (until):

2026-09-04

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

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Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

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Inquiry History

Description

Product Detail

Dihydroergotoxine mesylate Basic information

Product Name:	Dihydroergotoxine mesylate
Synonyms:	cck179;circanol;co-dergocrinemesylate;dihydroergotoxinemesilate;dihydroergotoxinemethanesulfonate;dihydroergotoxinemethanesulphonate;dihydroergotoxinemonomethanesulfonate(salt);dihydroergotoxinmesylate
CAS:	8067-24-1
MF:	C20H29N3O5S
MW:	423.53
EINECS:
Product Categories:
Mol File:	8067-24-1.mol

Dihydroergotoxine mesylate Chemical Properties

storage temp.	Store at RT
solubility	DMSO: Slightly Soluble; Methanol: 1 mg/ml
form	Solid
color	White to off-white
InChIKey	ONYMVHQTXOEAOV-TZWRWDCZNA-N
SMILES	C12C3=CC=CC=1[C@@]1([H])C[C@H](CN(C)[C@]1([H])CC2=CN3)C(=O)N[C@@H](C)CO.S(=O)(=O)(O)C \|&1:6,9,13,22,r\|

Safety Information

Hazard Codes	T
Risk Statements	60
Safety Statements	53-36/37/39-45
RIDADR	1544
RTECS	KE8800000
HazardClass	6.1(b)
PackingGroup	III
HS Code	3003490000

MSDS Information

Dihydroergotoxine mesylate Usage And Synthesis

Description	Ergoloid, also known as dihydroergotoxine mesylate, is a mixture of the ergot alkaloids dihydroergocornine, dihydroergocrystine, and dihydroergocryptine. It blocks reflex vasodilation and vasoconstriction induced by norepinephrine in dogs when injected into the kidney at a dose of 0.15 mg. Ergoloid blocks norepinephrine-induced cAMP production in rat brain cortical homogenates ex vivo in a dose-dependent manner. It also acts as an erectogenic agent in rats. Formulations containing ergoloid have been used in the treatment of migraine headaches and vascular dementias.
Uses	Cognition adjuvant. Dihydroergotoxine mesylate binds with high affinity to GABAA receptor Cl- channel. Interacts with central dopaminergic, serotonergic and adrenergic (a1) receptors. Exhibits antirproliferative activity in vitro. Displays cognition-enhancing, anticonvulsant and sedative activity in vivo. Dihydroergotoxine mesylate is a substrate of GABA Receptor.
Definition	ChEBI: Dihydroergotoxine mesylate is a mixture of hydrogenated ergot alkaloids consisting of the methanesulfonic acid salts of dihydroergocornine (R = CHMe2), dihydroergocristine (R = CH2Ph), and alpha- and beta-dihydroer ocryptine (R = CH2CHMe2 and CH(Me)Et, respectively). It is used for the symptomatic treatment of mild to moderate dementia in the elderly, although its value is not established.
Brand name	Alkergot (Sandoz); Circanol(3M Pharmaceuticals); Deapril (Bristol-Myers Squibb);Gerimal (Watson); Hydergine (Novartis).
Biological Activity	Dihydroergotoxine mesylate is a complex of closely related alkaloid salts. Binds with high affinity to the GABAA receptor Cl- channel, producing an allosteric interaction with the benzodiazepine site. Also interacts with central dopaminergic, serotonergic and adrenergic (α1) receptors. Displays antiproliferative activity in vitro (IC50 = 18 - 38 μM in prostate cancer cells) and exhibits cognition-enhancing, anticonvulsant and sedative activity in vivo.
Pharmacology	The metabolic effects of ergoloid mesylates (Hydergine) may include enhancement of noradrenergic, dopaminergic and serotoninergic neurotransmission (Weil,1988) and reduction of free radicals. Schneider and Olin (1994) reviewed 151 reports on the use of Hydergine in senile dementia, but only 47 of these trials (31%) met strict criteria for meta-analysis. ACochrane review (Olin et al., 2001) confirmed that patients with VaD appeared to benefit more than patients with AD in terms of cognition,clinical global ratings and combined measures. However, compared with placebo, efficacy was very modest. Thus, there are no grounds to recommend its use.
References	[1] S MATSUSHITA. Pharmacological studies on reflex renal vasodilatation.[J]. Tohoku Journal of Experimental Medicine, 1969, 99 1: 51-57. DOI: 10.1620/tjem.99.51 [2] R. MARKSTEIN H. W. The effect of dihydroergotoxin, phentolamine and pindolol on catecholamine-stimulated adenylcyclase in rat cerebral cortex[J]. FEBS Letters, 1975, 55 1: Pages 275-277. DOI: 10.1016/0014-5793(75)81010-6 [3] MILOVAN RADOSAVLJEVIC. Influence of Dihydroergotoxine, Bromocriptine, and Ergotamine on Penile Erection in Wistar Rats[J]. Journal of andrology, 2013, 33 5: 866-871. DOI: 10.2164/jandrol.111.015461

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ECHEMI Editorial Reference

Dihydroergotoxine mesylate is a complex of closely related alkaloid salts; Binds with high affinity to the GABAA receptor Cl- channel, producing an allosteric interaction with the benzodiazepine site.IC50 value:Target: Dihydroergotoxine mesylate also interacts with central dopaminergic, serotonergic and adrenergic (α1) receptors. Dihydroergotoxine mesylate displays antiproliferative activity in vitro (IC50 = 18 - 38 μM in prostate cancer cells) and exhibits cognition-enhancing, anticonvu

Basic Info

Product Name:

Dihydroergotoxine mesylate

Other Name:

Ergotoxine,dihydro-,methanesulfonate (1:1);Hydergine;Ergotoxine,dihydro-,monomethanesulfonate (salt);Indolo[4,3-fg]quinoline,ergotoxine deriv.;8H-Oxazolo[3,2-a]pyrrolo[2,1-c]pyrazine,ergotoxine deriv.;Dihydroergotoxine methanesulfonate;CCK 179;Hydergin;Dihydroergotoxin methanesulfonate;Dihydroergotoxine mesylate;Dihydroergotoxin mesylate;Circanol;Ischelium;Redergin;Co-dergocrine mesylate;Codergocrine methanesulfonate;Ergoloid mesylates;Coristin;Codergine mesylate;Co-dercrine mesylate;Novofluen;Dacoren;Ergohydrin;Ergoplus;Trigot;Sponsin;Dulcion;Ergodesit;Perenan;Progeril;Decril;Deapril ST;Hydergyne;Orphol;Dihydroergotoxine mesilate;Alkergot;Deapril;Gerimal;8031-73-0;11006-63-6;12645-43-1;42615-51-0;52655-92-2

CAS No.:

8067-24-1

Molecular Formula:

CH4O3S.Unspecified

InChIKeys:

CRFFPDBJLGAGQL-UHFFFAOYSA-N

Molecular Weight:

423.53

Exact Mass:

233.066363

HScode:

3003490000

Categories:

Standard

Characteristics

PSA:

131.11000

XLogP3:

2.53850

Density:

1.34g/cm3

Boiling Point:

899.5ºC at 760 mmHg

Flash Point:

497.8ºC

Refractive Index:

1.66

Storage Conditions:

Store at RT

See More Dihydroergotoxine mesylate Properties 

Hazard Identification

Classification of the substance or mixture

Flammable solids, Category 1

Acute toxicity - Category 4, Oral

Acute toxicity - Category 4, Inhalation

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 3

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H228 Flammable solid H302 Harmful if swallowed H332 Harmful if inhaled H412 Harmful to aquatic life with long lasting effects
Prevention	P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P240 Ground and bond container and receiving equipment. P241 Use explosion-proof [electrical/ventilating/lighting/...] equipment. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area. P273 Avoid release to the environment.
Response	P370+P378 In case of fire: Use ... to extinguish. P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P317 Get medical help.
Storage	none
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Dihydroergotoxine mesylate Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

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Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221
Weekly Price

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Inquiry History

4 Inquiries

Country	Product	Purchase Quantity	Date Posted
India	Dihydroergotoxine Mesylate	1000 KG	Dec 11, 2024
United Kingdom	Dihydroergotoxine mesylate in stock	1 G	Aug 3, 2026
United States	ERGOLOID MESYLATES	50 G	Apr 4, 2026
Pakistan	Dihydroergotoxine mesilate	10 KG	May 14, 2024

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Dihydroergotoxine mesylate8067-24-1

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