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Escin6805-41-0C55H86O24

Name: Escin6805-41-0C55H86O24
Brand: OORENT
SKU: pr2608111636
Price: 33 USD
Availability: InStock

3 Inquiries

Unit Price:

$33-34/MT FOB

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CAS No.:

6805-41-0

Grade:

Pharmaceutical Grade

Content:

99%

Port:

上海

Brand:

OORENT

Packaging:

vial

Price valid (until):

2027-01-01

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

Qualification:

Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
Seller Information
Inquiry History

Description

Product Detail

Escin Basic information

Product Name:	Escin
Synonyms:	BETA-AESCIN;ESCIN;Chestnuts extract;(2S,3S,4S,5R,6R)-6-[[(3S,4R,4aR,6aR,6bS,8R,8aS,9S,10S,12aR,14aR,14bS)-9-Acetyloxy-8-hydroxy-4,8a-bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-10-[(Z)-2-methylbut-2-enoyl]oxy-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-4-hydroxy-3,5-bis[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy]oxane-2-carboxylic acid;a-4700;aescusan;amorphousaescin;escina
CAS:	6805-41-0
MF:	C55H86O24
MW:	1131.26
EINECS:	229-880-6
Product Categories:	Inhibitors;Herb extract
Mol File:	6805-41-0.mol

Escin Chemical Properties

Melting point	224.5°C
Boiling point	764.81°C (rough estimate)
density	1.1200 (rough estimate)
refractive index	1.6500 (estimate)
storage temp.	4°C, protect from light
solubility	Soluble in methanol.
form	powder
color	white
biological source	plant (Aesculus chinensis)
Merck	13,3730
Stability:	Hygroscopic
Cosmetics Ingredients Functions	TONIC
InChIKey	AXNVHPCVMSNXNP-YSYFQUGBSA-N
CAS DataBase Reference	6805-41-0

Safety Information

Hazard Codes	Xn
Risk Statements	22-20/22
Safety Statements	22-24/25
RIDADR	UN 3077 9 / PGIII
WGK Germany	2
RTECS	KF6296000
Storage Class	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Inhalation Acute Tox. 4 Oral

MSDS Information

Provider	Language
SigmaAldrich	English

Escin Usage And Synthesis

Chemical Properties	saponin mixture
Originator	Aescin,Sinochem
Uses	escin is a saponin occurring in the seed of the horse chestnut tree.
Uses	Escin, a natural mixture of triterpenoid saponins isolated from horse chestnut (Aesculus hippocastanum) seeds, is used and studied as a vasoprotective anti-inflammatory, anti-edematous and anti-nociceptive agent. It may be used to study its pharmacokinetics, safety and efficacy as a chemosensitizer and modulator of NF-κ B cell signaling.
Uses	membrane permeabilizer
Manufacturing Process	The 1st method of preparation of escin (US Patent No. 3,238,190): 500 g of pulverized horse chestnut seeds were extracted two times for 1 hour with 2.5 L each of aqueous 50% methanol with stirring. The solution was filtered, additional methanol was added thereto to increase the methanol concentration to 65%, and then it was filtered again. The obtained solution containing the extracted saponin had a pH of 5 and was passed through a column of 500 ml (wet volume) of cation exchange resin (Lewatit S-100 of Farben-fabriken Bayer A.G.) which had been treated with 65% methanolic 1% sulfuric acid and then had been washed neutral with 65% methanol. The solution leaving the resin had a pH in the range of about 3 to 4 and was concentrated by distillation to about 4/5 of its original volume. On cooling, crystallization of the escin started and the solution was allowed to stand until the crystallization had been completed. Escin having a melting point of 224- 226°C was obtained in a yield of 2%, calculated on the starting material. The 2st method of preparations of escin (US Patent No. 3,163,636): An ethereal solution of 1 kg of cholesterol is added to 100 kg of a 10% aqueous-alcoholic horse extract. The resulting emulsion is stirred at 90°C for 1 hour, while the ether is distilled off. The water insoluble saponin-cholesterol precipitate is centrifuged and washed with cold water until the wash water is colorless. The precipitate is air-dried at room temperature. The resulting dustfine powder is extracted with ether in a Soxhlet apparatus for 10 days. The residue is treated with 20 kg of methanol and the undissolved material is filtered off. The yellowish methanol solution is treated with activated charcoal until it is colorless. The methanol is distilled off in a vacuum, and the residue is dried over phosphorus pentoxide in a vacuum not exceeding 1 mm Hg. The yield of pure sodium escinate obtained thereby is about 0.8 kg (8%).
Therapeutic Function	Antiedemic, Capillary protective
General Description	This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
Flammability and Explosibility	Non flammable

Escin Preparation Products And Raw materials

Raw materials

Methanol-->Cholesterol

Physical & Chemical Properties

Appearance: Off-white / pale beige fine crystalline powder
Odor: Characteristic mild herbal odor
Solubility: Soluble in methanol, ethanol, DMSO; sparingly soluble in cold water, better soluble in warm water
Melting range: 220–226 ℃ (decomposition)
pH (aqueous suspension): 4.5–6.0
Stability: Stable under dry & cool condition; avoid strong acid, strong alkali and prolonged heating

Storage & Shelf Life

Powder storage: Sealed, cool & dry, protect from light, 2–8 ℃ preferred
Shelf life: 24 months under proper storage
Solution: Aqueous solution unstable, prepare freshly; avoid long-term storage.
Mechanism of Biological Activity
1. Vasoprotective & venotonic effect Improves venous wall tension, reduces venous stasis, enhances lymphatic drainage.
2. Anti-edema / Reduce capillary permeability Inhibits lysosomal enzyme release, decreases fluid leakage into interstitial tissue.
3. Anti-inflammatory & antioxidant Suppresses NF-κB pathway, lowers inflammatory mediators; scavenges reactive oxygen species.
4. Cosmetic effect Relieves skin swelling, improves microcirculation, reduces puffiness; used for sensitive & tired skin care.

Signal Word: Warning Hazard Statements

H302 Harmful if swallowed
H319 Causes serious eye irritation
H335 May cause respiratory irritation
H411 Toxic to aquatic life with long lasting effects

Precaution: Avoid dust inhalation; wear goggles & gloves during handling. Not dangerous goods for sea/air transport (UN non-regulated).

8. Short English Sales Introduction (Directly send to overseas buyers)

Escin (Aescin)

Escin is natural triterpenoid saponin extracted from Horse Chestnut seeds. It possesses well-documented venotonic, anti-edema and anti-inflammatory properties. Widely used in pharmaceutical venous health formulations and anti-puffiness skincare raw materials.

We supply two grades:

Pharma grade ≥98% HPLC (high β-Escin)
Standard extract grade 60% / 90% Escin Packing: 1kg / 5kg / 25kg aluminum foil bag & fiber drum. Storage: Cool, dry and light-proof environment.

Disclaimer: For formulation & research purpose only; not a finished medicine.Important Note: Escin = Aescin (interchangeable). It is a mixture of triterpenoid saponins extracted from Aesculus hippocastanum (Horse Chestnut) seeds. Two main fractions: α-Escin & β-Escin; β-Escin carries major biological activity.

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ECHEMI Editorial Reference

Escin, a natural mixture of triterpenoid saponins isolated from horse chestnut (Aesculus hippocastanum) seeds, can be used as a vasoprotective anti-inflammatory, anti-edematous and anti-nociceptive agent[1].

Basic Info

Product Name:

Escin

Other Name:

Escin;Escigenin,3-(4-O-β-D-glucopyranosyl-2-O-β-D-xylopyranosyl-β-D-glucopyranuronoside),3-hydroxy-2-methylbutyrate,acetate;Oleanane,escin deriv.;3,5-Epoxypicene,escin deriv.;Aescin;Ba 2672;β-Escinic acid;Aescusan;Aescine;Escusan;Eskuzan;Venocin;Flebostasin Retard;37-02-5;1394-90-7;25255-37-2;47918-34-3;55125-87-6

CAS No.:

6805-41-0

InChIKeys:

AXNVHPCVMSNXNP-YSYFQUGBSA-N

Molecular Weight:

2262.51000

Exact Mass:

2261.10000

EC Number:

229-880-6

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

776.08000

XLogP3:

-2.64220

Appearance:

white powder

Density:

1.46 g/cm3

Melting Point:

200-210 °C (decomp) @ Solvent: Ethanol

Boiling Point:

1140.6ºC at 760 mmHg

Flash Point:

311.8ºC

Refractive Index:

1.627

Water Solubility:

soluble in methanol.

See More Escin Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 4, Oral

Eye irritation, Category 2

Acute toxicity - Category 4, Inhalation

Specific target organ toxicity â single exposure, Category 3

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H302+H332 Harmful if swallowed or if inhaled H319 Causes serious eye irritation H335 May cause respiratory irritation H411 Toxic to aquatic life with long lasting effects
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area. P273 Avoid release to the environment.
Response	P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P317 Get medical help. P319 Get medical help if you feel unwell. P391 Collect spillage.
Storage	P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Escin Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

A reliable supplier is like insurance.

We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
Integrity is the foundation, quality is life. We would like to work together with you to build a greener and brighter future.

Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

3 Inquiries

Country	Product	Purchase Quantity	Date Posted
India	Aescin	1 KG	Aug 19, 2025
Vietnam	Escin	40 KG	Aug 11, 2026
Egypt	Aescin	50 G	Jul 10, 2025

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