Bupivacaine CAS 2180-92-9 Long-Acting Amide-Type Local Anesthetic for Surgery and Pain Management Research hfd
TDS
2180-92-9
Reagent Grade
99%
qingdao
//
5g, 25g, 100g, 500g
Yes
2026-09-16
Medetomidine,Medetomidine hydrochloride,D-Lysergic Acid Methyl Ester,SR17018,Fluralaner,GS-441524
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Product Description
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Seller Information
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DescriptionECHEMI Editorial ReferenceSolid
ChEBI: 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide is a piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline. It is a piperidinecarboxamide, an aromatic amide and a tertiary amino compound. It is a conjugate base of a 1-butyl-2-[(2,6-dimethylphenyl)carbamoyl]piperidinium.
Bupivacaine was synthesized simultaneously with mepivacainein 1957 but was at first overlooked because of the increasedtoxicity compared with mepivacaine. When themethyl on the cyclic amine of mepivacaine is exchanged fora butyl group the lipophilicity, potency and the duration ofaction all increase. Literature reports of cardiovascular toxicity,including severe hypotension and bradycardia, areabundant in the literature.91 Bupivacaine is highly bound toplasma proteins (95%), and thus the free concentration mayremain low until all of the protein binding sites are occupied.After that point, the plasma levels of bupivacaine rise rapidlyand patients may progress to overt cardiac toxicity withoutever showing signs of CNS toxicity. The cardiotoxicity ofbupivacaine is a result of its affinity to cardiac tissues and itsability to depress electrical conduction and predispose theheart to reentry types of arrhythmias. The cardiotoxicity ofbupivacaine was found to be significantly more prominentwith the “R” isomer, or the racemic mixture, thus the “S”stereoisomer is now on the market as levobupivacaine.Certificates-
TDS
Basic Info-
Product Name:
Bupivacaine
Other Name:MARCAINE;BUPIVACAINE;BUPIVACAINE BASE;2',6'-Pipecoloxylidide, 1-butyl-;6’-pipecoloxylidide,1-butyl-2;Anekain;Carbostesin;DL-Bupivacaine
CAS No.:2180-92-9
Molecular Formula:C18H28N2O
InChIKeys:LEBVLXFERQHONN-UHFFFAOYSA-N
Molecular Weight:288.43
Exact Mass:288.43
EC Number:218-553-3
Categories:
Characteristics-
PSA:
32.3
XLogP3:3.6
Appearance:Solid
Density:1.0238 (rough estimate)
Melting Point:107.5-108°
Boiling Point:430.65°C (rough estimate)
Flash Point:209.9±28.7 °C
Refractive Index:1.5700 (estimate)
Water Solubility:101.5mg/L(25 ºC)
Storage Conditions:Bupivacaine hydrochloride solutions should be stored between 15-30 deg C and freezing should be avoided; solutions containing epinephrine should be protected from light.
Vapor Pressure:1.31X10-7 mm Hg at 25 deg C (est)
Toxicity:Highly toxic
Flammability characteristics:Thermal decomposition to emit toxic nitrogen oxide fumes
PKA:8.09; also reported as 8.17(at 25℃)
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 2, Oral
Acute toxicity - Category 1, Dermal
Skin irritation, Category 2
Serious eye damage, Category 1
Acute toxicity - Category 2, Inhalation
GHS label elements, including precautionary statements
Pictogram(s)
Signal word Danger
Hazard statement(s) H300 Fatal if swallowed
H310 Fatal in contact with skin
H315 Causes skin irritation
H318 Causes serious eye damage
H330 Fatal if inhaled
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P262 Do not get in eyes, on skin, or on clothing.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P284 [In case of inadequate ventilation] wear respiratory protection.
Response P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P316 Get emergency medical help immediately.
P361+P364 Take off immediately all contaminated clothing and wash it before reuse.
P332+P317 If skin irritation occurs: Get medical help.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P354+P338 IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P317 Get medical help.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P320 Specific treatment is urgent (see ... on this label).
Storage P405 Store locked up.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store in tight container as defined in the USP-NF. This material should be handled and stored per label instructions to ensure product integrity. Bupivacaine hydrochloride
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Seller Information
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Business Type:
Trader
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Main Products:
Medetomidine,Medetomidine hydrochloride,D-Lysergic Acid Methyl Ester,SR17018,Fluralaner,GS-441524
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Location:
RONGSHENG BEIYUANDAJIE 9, LICHENG DISTRICT,JINAN, SHANDONG CHINA
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Payment Terms:
TT against copy of documents,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
7 days
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Total Annual Revenue:
$1 million-$2.5 million
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Total Employees:
11-50
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Year of Establishment:
2022
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
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