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THIP HYDROCHLORIDE64603-91-4

Name: THIP HYDROCHLORIDE64603-91-4
Brand: OORENT
SKU: pr2608191768
Price: 33 USD
Availability: InStock

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$33-34/MT FOB

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CAS No.:

64603-91-4

Grade:

Pharmaceutical Grade

Content:

99.5%

Port:

shanghai

Brand:

OORENT

Packaging:

Vial/Bottle/Bag/Carton

Price valid (until):

2027-07-20

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

Qualification:

Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
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Description

Product Detail

THIP HYDROCHLORIDE Basic information

Product Name:	THIP HYDROCHLORIDE
Synonyms:	THIP HYDROCHLORIDE;4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3(2h)-onehydrate;4-c)pyridin-3(2h)-one,4,5,6,7-tetrahydro-isoxazolo(hydrate;4,5,6,7-TETRAHYDROISOXAZOLO[5,4-C]PYRIDIN-3-OL HYDROCHLORIDE;4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3(2H)-one;4,5,6,7-Tetrahydroisoxazole(5,4-C)pyridin-3-ol;Einecs 264-963-0;Gaboxadolum [latin]
CAS:	64603-91-4
MF:	C6H8N2O2
MW:	140.14
EINECS:	264-963-0
Product Categories:	GABA/Glycine receptor
Mol File:	64603-91-4.mol

THIP HYDROCHLORIDE Chemical Properties

Melting point	242-244° (dec)
density	1.36±0.1 g/cm3(Predicted)
storage temp.	Store at RT
solubility	ethanol: 0.91 mg/mL
pka	pKa (water, 25°): 4.44 ±0.03; 8.48 ±0.04
form	solid
color	white
Stability:	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.

Safety Information

Safety Statements	22-24/25
WGK Germany	3
RTECS	NY3396800

MSDS Information

Provider	Language
SigmaAldrich	English

THIP HYDROCHLORIDE Usage And Synthesis

Description

Gaboxadol HCl (64603-91-4) is a GABA-A receptor agonist. Hypnotic agent.

Uses

GABAa agonist, GABAc antagonist

Definition

ChEBI: 4,5,6,7-Tetrahydroisoxazolo(5,4-c)pyridin-3-ol is an oxazole.

Biological Activity

Systemically active GABA A receptor agonist and GABA C receptor antagonist. Displays antinociceptive, anticonvulsant and sedative effects. Hypnotic agent that enhances delta activity within non-REM sleep in rats.

in vivo

THIP (Gaboxadol) (0.5, 5.0 mg/kg; p.o.; single) shws a good oral utilization, with F_a values of 110% and 83% for dosage of 0.5 and 5.0 mg/kg, respectively^[2].

Animal Model:

Sprague-Dawley rats (255-276 g)^[2].

Dosage:

2.5 mg/kg (for i.v.); 0.5 and 5.0 mg/kg (for p.o.).

Administration:

Oral gavage; intravenous injection; single.

Result:

1.19Pharmacokinetic Parameters of THIP 4 in Sprague-Dawley rats ^[2].

	IV (2.5 mg/kg)	PO (0.5 mg/kg)	PO (5.0 mg/kg)
AUC (ng/mLh)	1193	263	1988
T_max (h)	-	0.22	0.33
C_max (ng/mL)	4350	291	2061
CL/F_a (mL/h/kg)	-	1939	2558
CL (mL/h/kg)	2043	-	-
F_a (%)	100	110	83

IC 50

α4β3δ GABAAR: 13 μM (EC₅₀)

References

[1] PRATAP MEERA Thomas S O Martin Wallner. Molecular basis for the high THIP/gaboxadol sensitivity of extrasynaptic GABA(A) receptors.[J]. Journal of neurophysiology, 2011, 106 4: 2057-2064. DOI:10.1152/jn.00450.2011

THIP HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

methyl 3,4,5,7-tetrahydro-3-oxoisoxazolo[5,4-c]pyridine-6(2H)-carboxylate

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ECHEMI Editorial Reference

4,5,6,7-Tetrahydroisoxazolo(5,4-c)pyridin-3-ol is an oxazole.|Gaboxadol also known as 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol (THIP) is an experimental sleep aid drug developed by Lundbeck and Merck, who reported increased deep sleep without the reinforcing effects of benzodiazepines. Development of Gaboxadol was stopped in March 2007 after concerns regarding safety and efficacy. It acts on the GABA system, but in a seemingly different way from benzodiazepines and other sedatives.

Basic Info

Product Name:

Gaboxadol

Other Name:

Isoxazolo[5,4-c]pyridin-3(2H)-one,4,5,6,7-tetrahydro-;4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3(2H)-one;THIP;4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-ol;Gaboxadol;Lu 02-030;2H,3H,4H,5H,6H,7H-[1,2]Oxazolo[5,4-c]pyridin-3-one

CAS No.:

64603-91-4

Molecular Formula:

C6H8N2O2

InChIKeys:

InChIKey=ZXRVKCBLGJOCEE-UHFFFAOYSA-N

Molecular Weight:

140.14 g/mol

Exact Mass:

140.14

EC Number:

264-963-0

UNII:

K1M5RVL18S

DSSTox ID:

DTXSID0045206

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

50.4 Å²

See More Gaboxadol Properties 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

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Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

23 Inquiries

Country	Product	Purchase Quantity	Date Posted
Netherlands	Wholesale gaboxadol CAS 64603-91-4 Fast Delivery	1 G	Oct 17, 2023
United States	THIP HYDROCHLORIDE, CAS:64603-91-4	1 G	Oct 10, 2023
United States	THIP HYDROCHLORIDE	1 G	Aug 20, 2026
United States	Gaboxadol	1 G	Nov 12, 2025
Denmark	Gaboxadol THIP HYDROCHLORIDE, CAS:64603-91-4	5 G	Oct 24, 2025
United States	Gaboxadol	500 MG	Oct 15, 2025
United States	THIP HYDROCHLORIDE	2 G	Aug 12, 2025
United States	gaboxadol	5 G	Mar 1, 2025
Poland	THIP HYDROCHLORIDE	1 KG	Dec 2, 2024
United States	THIP HYDROCHLORIDE 99% White powder Lingding	1 KG	Sep 12, 2023
United States	THIP HYDROCHLORIDE	1 G	Aug 19, 2026
United States	Gaboxadol	50 G	Aug 6, 2025
United States	Gaboxadol	25 G	Jun 9, 2025
United States	THIP HYDROCHLORIDE	1 G	Jan 30, 2025
Germany	Gaboxadol	10 G	Feb 2, 2024
Czech	gaboxadol	1 KG	Jan 15, 2024
Greece	THIP HYDROCHLORIDE 99% white solid	0.5 KG	May 18, 2026
United States	4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3(2h)-onehydrate	2 G	May 17, 2026
Denmark	THIP HYDROCHLORIDE	2 G	Nov 21, 2025
United States	Gaboxadol	2 G	Aug 3, 2025

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