Gaboxadol
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Gaboxadol
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CAS No:
64603-91-4
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Formula:
C6H8N2O2
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Chemical Name:
Gaboxadol
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Synonyms:
Isoxazolo[5,4-c]pyridin-3(2H)-one,4,5,6,7-tetrahydro-;4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3(2H)-one;THIP;4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-ol;Gaboxadol;Lu 02-030;2H,3H,4H,5H,6H,7H-[1,2]Oxazolo[5,4-c]pyridin-3-one
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CAS No:
Description
4,5,6,7-Tetrahydroisoxazolo(5,4-c)pyridin-3-ol is an oxazole.|Gaboxadol also known as 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol (THIP) is an experimental sleep aid drug developed by Lundbeck and Merck, who reported increased deep sleep without the reinforcing effects of benzodiazepines. Development of Gaboxadol was stopped in March 2007 after concerns regarding safety and efficacy. It acts on the GABA system, but in a seemingly different way from benzodiazepines and other sedatives.
Drug Information
Investigated for use/treatment in sleep disorders and insomnia.
Endogenous compounds and drugs that bind to and activate GAMMA-AMINOBUTYRIC ACID receptors (RECEPTORS, GABA). (See all compounds classified as GABA Agonists.)|Compounds capable of relieving pain without the loss of CONSCIOUSNESS. (See all compounds classified as Analgesics.)|Drugs used to prevent SEIZURES or reduce their severity. (See all compounds classified as Anticonvulsants.)
4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol
Computed Properties
Molecular Weight:140.14
XLogP3:-0.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Exact Mass:140.058577502
Monoisotopic Mass:140.058577502
Topological Polar Surface Area:50.4
Heavy Atom Count:10
Complexity:210
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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