TB500 (Thymosin B4 Acetate) | Lyophilized Powder | Cosmetic Grade Peptide | 99% Purity | 5mg/10mg Vials | Global Delivery

Full Product Description

TB-500, also known , is one of the most widely studied synthetic peptides in regenerative biology research., TB-500 retains key biological sequences regulating intracellular actin dynamics, making it a core material for laboratory research related to tissue regeneration, wound repair, and cell migration. Our Novio brand TB-500 lyophilized peptide powder is manufactured using strict purification standards and tested by high-performance liquid chromatography (HPLC) to ensure a purity of ≥99%. Each batch comes with complete testing documentation to meet the needs of academic laboratories, research institutions, and peptide distributors worldwide.

All products are for laboratory research use only. This peptide reagent is not approved for human consumption, injection, or veterinary clinical use. Any statement on this page should not be construed as clinical guidance for living organisms.

What is TB-500?

TB-500 is a synthetic single-chain peptide with the amino acid sequence LKKTETQ and CAS registry number 77591-33-4. Thymosin β-4 is naturally present in various mammalian cells and tissues, participating in the regulation of the cytoskeleton. Researchers have discovered that the TB-500 fragment is the main active domain mediating cell migration and tissue remodeling.

 the TB-500 fragment has advantages such as smaller molecular weight, better stability after recombination, and lower production costs, thus gradually becoming the preferred alternative in most regenerative medicine experimental models. TB-500 is supplied in lyophilized white powder form to minimize peptide degradation during transportation and long-term storage.

Core Research Mechanisms of TB-500

Extensive in vitro cell experiments and animal model studies have been conducted to explore the bioactivity of TB-500. Current mainstream research focuses on the following biological pathways:

Acetin Binding and Cytoskeleton Regulation

Acetin is a fundamental building block of cell structure and cell movement. TB-500 can bind to globular actin and regulate actin polymerization balance, thereby directly affecting cell morphology, cell migration, and cell adhesion behavior. This mechanism lays the foundation for tissue remodeling research.

Cell Migration Regulation

Controlled cell migration is crucial for wound healing and damaged tissue remodeling. Laboratory data show that TB-500 promotes the directed migration of epithelial cells, fibroblasts, and endothelial cells, accelerating the reconstruction of damaged tissue structures in experimental models.

Angiogenesis Regulation

Damage repair depends on the formation of new microvessels. Multiple studies have shown that TB-500 supports endothelial cell activity, thereby promoting microvessel formation within damaged tissue samples.

TB-500 Exhibits Moderate Anti-inflammatory Effects in Tissue Injury Models

In laboratory tissue injury models, TB-500 has been observed to modulate local inflammatory responses, helping to maintain the homeostatic microenvironment required for tissue repair.

Laboratory Research Applications

Our research-grade TB-500 lyophilized powder is suitable for a variety of academic and commercial laboratory research applications:

In vitro cell culture experiments: migration testing of fibroblasts, epithelial cells, and endothelial cells

Preclinical wound healing model studies (animal models only)

Soft tissue injury, tendon, and connective tissue regeneration studies

Exploring angiogenesis and vascular biology mechanisms

Basic research on the cytoskeleton and cell signaling pathways

Product Specifications

Reconstitution Instructions

TB-500 is shipped as a lyophilized solid. Before laboratory testing, please reconstitute the powder using a suitable solvent (e.g., sterile antibacterial water or laboratory-grade PBS buffer).

Suggested Procedure:

Maintain a low temperature during reconstitution to minimize loss of peptide activity.

Slowly pour the solvent along the inner wall of the vial. Do not shake the vial vigorously; gently rotate the vial until all powder is completely dissolved.

Avoid repeated freeze-thaw cycles on the reconstituted peptide solution.

Storage and Stability

Unopened lyophilized vials: Store at -20°C to -80°C. Shelf life is up to 24 months under sealed frozen conditions. Store away from light and moisture.

Reconstituted aqueous solution: Can be stored at 2°C to 8°C for up to 7 days. For long-term use after reconstitution, aliquot and freeze at -20°C.

Transportation: We utilize dry ice cold chain shipping for bulk orders to ensure peptide stability during transit.

Novio Brand Advantages

As a reliable supplier of peptides for laboratory research, Novio implements rigorous quality control for all peptide products (including TB-500):

Each batch undergoes high-performance liquid chromatography (HPLC) purity testing. Certificates of Analysis (COA) are available upon request.

Vacuum freeze-drying technology effectively reduces peptide oxidation and degradation.

Flexible packaging options cater to both retail sample orders and large-volume wholesale needs. We offer customized labeling services for bulk partners.

Stable inventory and proven cold chain logistics solutions ensure global shipping.

A professional technical support team answers researchers' laboratory operation questions.

Wholesale and Cooperation

We welcome global research institutions, biochemical product distributors, and laboratory reagent suppliers to discuss long-term cooperation. Bulk orders enjoy highly competitive pricing. If you require customized concentrations, special packaging, or mixed peptides, please send your detailed requirements to our business email address.

Important Disclaimer

This product is for laboratory research use only. This product is not for human or veterinary use.

This product is a biochemical research reagent. It is not for human, oral, disease treatment, or animal clinical treatment. All descriptions on this page summarize published academic research findings only and do not constitute any functional claims suitable for human or animal use. The buyer assumes full responsibility for complying with local import laws, customs regulations, and laboratory safety operating standards.