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Home > Pharmaceutical Intermediates > Bulk Drug Intermediates > Vildagliptin for Sale > Vildagliptin CAS 274901-16-5 Potent DPP-4 Inhibitor for Type 2 Diabetes hfd
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Vildagliptin CAS 274901-16-5 Potent DPP-4 Inhibitor for Type 2 Diabetes hfd

TDS 5 Inquiries

Unit Price:

$100-130/G FOB

Get Latest Price
CAS No.:

274901-16-5

Grade:

Reagent Grade

Content:

99%

Port:

qingdao

Brand:

//

Packaging:

5g, 25g, 100g, 500g

Price valid (until):

2026-09-28

Company Type:
Trader
Location:
China
Qualification:
Main Products:

Medetomidine,Medetomidine hydrochloride,D-Lysergic Acid Methyl Ester,SR17018,Fluralaner,GS-441524

  • Product Description

  • Seller Information

  • Inquiry History

  • Description

    —— Product Specification ——

    Parameter Specification Details
    Product Name Vildagliptin (S)-1-((3-Hydroxy-1-adamantyl)glycyl)pyrrolidine-2-carbonitrile
    CAS Number 274901-16-5 274901-16-5
    Molecular Formula C₁₇H₂₅N₃O₂ 17 carbons, 25 hydrogens, 3 nitrogens, 2 oxygens
    Molecular Weight 303.40 g/mol
    Appearance White to off-white crystalline powder Visual inspection
    Purity ≥98.0% Determined by HPLC
    Melting Point 149 – 155°C
    Solubility Soluble in DMSO; slightly soluble in water
    GI Absorption High
    BBB Permeant No
    P-gp Substrate Yes
    Storage -20°C for long-term; 2-8°C for short-term Sealed containers, protect from moisture
    Packaging 1g, 5g, 10g, 25g, 100g Amber glass vials
    Application Research use only Diabetes research, DPP-4 inhibition studies


    —— Product Detail ——

    Product Overview

    • Vildagliptin (CAS 274901-16-5), also known as LAF237 and marketed under the brand name Galvus, is an orally active, potent, and selective dipeptidyl peptidase-4 (DPP-4) inhibitor . It appears as a white to off-white crystalline powder with the molecular formula C₁₇H₂₅N₃O₂ and a molecular weight of 303.40 g/mol . The chemical name is (S)-1-((3-hydroxy-1-adamantyl)glycyl)pyrrolidine-2-carbonitrile .


    Packaging & Shipping

                  • Research quantities: 5mg, 10mg, 25mg amber glass vials

                  • Bulk quantities: 50mg, 100mg amber glass bottles

                  • Custom packaging available upon request

                  • Not classified as hazardous material for transport under normal conditions

                  • Product for research and analytical use only; not for human therapeutic use

    Shop CAS 18048-64-1 Eltrombopag Intermediate for Pharmaceutical Research  kr-Detailed Image 1

    Company profile ——


     Shop CAS 1231930-42-9 Abemaciclib Intermediate for Pharma researech use KR-Detailed Image 1

    Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.

    Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.

    We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.

    To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.

    Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers.

     

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    —— Q&A ——

    Q1: How to confirm the product quality before placing orders?
    A: By sending you available samples. Or if you have special requirements for the goods, we can prepare samples according to your requirements for confirmation.

    Q2: Can you supply free samples?
    A: Yes, we can provide a free sample, but the shipping cost will be paid by the customers. You can either pay the shipping cost or arrange a courier to collect the samples.

    Q3: How do you treat quality complaints?
    A: All our products are strictly tested by our QC and confirmed by QA; unqualified material will not be released to customers. If any quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately.

    Q4: What is your MOQ? Is there a discount?
    A: For highvalue products, our MOQ starts from 1g and generally starts from 10g. For other lowprice products, our MOQ starts from 100g and 1kg.
    Q: Is there a discount?
    A: Yes, for larger quantities, we always support with better prices.

    Q5: How to start orders or make payments?
    A: You can send us your Purchase Order (if your company has one), or just send a simple confirmation by email or via Trade Manager. We will then send you a Proforma Invoice with our bank details for your confirmation, and you can make payment accordingly. If you have other preferred payment methods, we are open to discussion and negotiation.



    ECHEMI Editorial Reference
    Vildagliptin (LAF-237; NVP-LAF 237) inhibits DPP-4 with IC50 of 2.3 nM.IC50 Value: 2.3 nM[1]Target: DPP-4in vitro: Vildagliptin is an N-substituted glycyl-2-cyanopyrrolidine (figure 2). It is a potent competitive and reversible inhibitor of human and rodent DPP-4 in vitro, with a median inhibitory concentration (IC50) ~2-3 nmol/L. Importantly, vildagliptin inhibits DPP-4 with high specificity relative to other similar peptidases where its IC50 exceeds 200 mol/L [1].in vivo: Compared to a
    A pyrrolidine-carbonitrile derivative and potent inhibitor of DIPEPTIDYL PEPTIDASE 4 that is used in the treatment of TYPE 2 DIABETES MELLITUS.

    Certificates
    • Vildagliptin CAS 274901-16-5 Potent DPP-4 Inhibitor for Type 2 Diabetes hfd Certificates 1 TDS

    Basic Info
    Product Name:

    Vildagliptin

    Other Name:

    2-Pyrrolidinecarbonitrile,1-[2-[(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)amino]acetyl]-,(2S)-;2-Pyrrolidinecarbonitrile,1-[[(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)amino]acetyl]-,(2S)-;(2S)-1-[2-[(3-Hydroxytricyclo[3.3.1.13,7]dec-1-yl)amino]acetyl]-2-pyrrolidinecarbonitrile;Vildagliptin;LAF 237;NVP-LAF 237;Galvus;Equa;DSP 7238;(S)-1-[2-[(3-Hydroxyadamant-1-yl)amino]acetyl]pyrrolidine-2-carbonitrile;(2S)-1-[2-[(3-Hydroxy-1-adamantyl)amino]acetyl]pyrrolidine-2-carbonitrile;Xiliarx;Jalra;565453-38-5

    CAS No.:

    274901-16-5

    Molecular Formula:

    C17H25N3O2

    InChIKeys:

    InChIKey=SYOKIDBDQMKNDQ-XWTIBIIYSA-N

    Molecular Weight:

    303.39900

    Exact Mass:

    303.40

    ATC Code:

    A10BH02|A10BD08|A - Alimentary tract and metabolism

    HScode:

    2933990090

    Characteristics
    PSA:

    76.36000

    XLogP3:

    1.50308

    Appearance:

    white crystalline powder

    Density:

    1.27 g/cm3

    Melting Point:

    148-150 °C @ Solvent: Ethyl acetate, Isopropanol

    Boiling Point:

    531.3ºC at 760 mmHg

    Flash Point:

    275.1ºC

    Hazard Identification

    Classification of the substance or mixture

    Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 4

    GHS label elements, including precautionary statements

    Pictogram(s) No symbol.
    Signal word

    No signal word

    Hazard statement(s)

    H413 May cause long lasting harmful effects to aquatic life

    Precautionary statement(s)
    Prevention

    P273 Avoid release to the environment.

    Response

    none

    Storage

    none

    Disposal

    P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

    Other hazards which do not result in classification

    no data available

    Handling and Storage

    Precautions for safe handling

    Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

    Conditions for safe storage, including any incompatibilities

    Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

  • Seller Information
    Business Type:

    Trader

    Main Products:

    Medetomidine,Medetomidine hydrochloride,D-Lysergic Acid Methyl Ester,SR17018,Fluralaner,GS-441524

    Location:

    RONGSHENG BEIYUANDAJIE 9, LICHENG DISTRICT,JINAN, SHANDONG CHINA

    Payment Terms:

    TT against copy of documents,TT against B/L draft before shipment,100% TT in advance

    Average lead Time:

    7

    Total Annual Revenue:

    $1 million-$2.5 million

    Total Employees:

    11-50

    Year of Establishment:

    2022

    Jinan Topfull Chemical Co., Ltd. is a global chemical Industrial and focuses on advanced chemical technology. Specialized in Cosmetic materials, water treatment, fine chemicals and so on. We are looking forward to working together with the people of all circles at home and abroad to seek common development!
  • Inquiry History
    5 Inquiries
    Country Product Purchase Quantity Date Posted
    India

    Vildagliptin

    5 MT Nov 25, 2025
    Bangladesh

    Vildagliptin

    1000.00 KG Jul 1, 2026
    India

    Vildagliptin

    100 KG Feb 13, 2026
    Tunisia

    Vildagliptin

    80 KG Dec 19, 2023
    India

    VILDAGLIPTIN

    100 KG Jul 22, 2025
    Post an enquiry for this product
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