High Quality 98% White Powder Vildagliptin CAS 274901-16-5

Vildagliptin More Info

Vildagliptin is an oral antihyperglycemic agent used in the management of type 2 diabetes mellitus. It belongs to a class of medications known as dipeptidyl peptidase-4 (DPP-4) inhibitors, which work by enhancing the body's natural ability to lower blood sugar levels.

Mechanism of Action

Vildagliptin functions primarily through the inhibition of the DPP-4 enzyme, which is responsible for the degradation of incretin hormones, specifically glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). By inhibiting DPP-4, vildagliptin leads to:
Increased Levels of GLP-1 and GIP: This results in enhanced insulin secretion from pancreatic beta cells in response to meals, while also suppressing glucagon release from alpha cells, thereby reducing hepatic glucose production.
Improved Glycemic Control: The increased levels of these incretin hormones help to lower fasting and postprandial blood glucose levels without causing significant hypoglycemia, as their action is glucose-dependent.

Applications

Vildagliptin is indicated for:
Type 2 Diabetes Management: It is used as monotherapy or in combination with other antidiabetic medications, including metformin and sulfonylureas, to improve glycemic control.
Preservation of Beta-cell Function: Clinical studies suggest that vildagliptin may help maintain beta-cell function over time in patients with type 2 diabetes.

Routes of Administration

Vildagliptin is available in oral tablet form and is typically taken once or twice daily, depending on the prescribed regimen. It can be used alone or in combination with other antidiabetic agents.