Firmonertinib CAS 1869057-83-9 Third-Generation EGFR TKI for NSCLC Research kr
TDS
1869057-83-9
Reagent Grade
99%
qingdao
//
5g, 25g, 100g, 500g
Yes
2026-10-01
Medetomidine,Medetomidine hydrochloride,D-Lysergic Acid Methyl Ester,SR17018,Fluralaner,GS-441524
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Product Details
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Seller Information
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DescriptionECHEMI Editorial ReferenceAlflutinib is under investigation in clinical trial NCT03452592 (Efficacy and Safety of Alflutinib in Locally Advanced or Metastatic Non-small Cell Lung Cancer Patients With T790M).|Alflutinib is an orally available selective inhibitor of the epidermal growth factor receptor (EGFR) mutant form T790M, with potential antineoplastic activity. Upon administration, alflutinib specifically binds to and inhibits the tyrosine kinase activity of EGFR T790M, a secondarily acquired resistance mutation. This prevents EGFR T790M-mediated signaling and leads to cell death in EGFR T790M-expressing tumor cells. EGFR, a receptor tyrosine kinase that is mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization. Compared to some other EGFR inhibitors, alflutinib may have therapeutic benefits in tumors with T790M-mediated drug resistance.Certificates
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TDS
Basic Info-
Product Name:
Alflutinib
Other Name:Alflutinib;AST2818;1869057-83-9;AST-2818;UNII-A49A7A5YN4;A49A7A5YN4;2-Propenamide, N-(2-((2-(dimethylamino)ethyl)methylamino)-5-((4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl)amino)-6-(2,2,2-trifluoroethoxy)-3-pyridinyl)-;N-[2-[2-(dimethylamino)ethyl-methylamino]-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]prop-2-enamide;Aflutinib;N-(2-(2-(dimethylamino)ethyl-methylamino)-5-((4-(1-methylindol-3-yl)pyrimidin-2-yl)amino)-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)prop-2-enamide
CAS No.:1869057-83-9
Molecular Formula:C28H31F3N8O2
InChIKeys:GHKOONMJXNWOIW-UHFFFAOYSA-N
Molecular Weight:568.6
Exact Mass:568.25220675
UNII:A49A7A5YN4
NCI Thesaurus Code:C180535
Categories:
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Seller Information
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Business Type:
Trader
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Main Products:
Medetomidine,Medetomidine hydrochloride,D-Lysergic Acid Methyl Ester,SR17018,Fluralaner,GS-441524
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Location:
RONGSHENG BEIYUANDAJIE 9, LICHENG DISTRICT,JINAN, SHANDONG CHINA
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Payment Terms:
TT against copy of documents,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
7 days
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Total Annual Revenue:
$1 million-$2.5 million
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Total Employees:
11-50
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Year of Establishment:
2022
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
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