Function
PNC-27, an anticancer peptide, containing an HDM-2 binding domain corresponding to p53 residues 12-26 and a transmembrane penetrating domain, has been found to kill cancer cells but not normal cells by inducing membrane lysis. The 3D structure of the p53 residue of PNC-27 directly overlaps the structure of the same residue that binds HDM-2, suggesting that this peptide may target HDM-2 in the cell membrane. The researchers found significant levels of HDM-2 in the cell membranes of a variety of cancer cells but not in some untransformed cell lines. In colocalization experiments, PNC-27 bound to cell membrane-bound HDM-2. The researchers used a membrane localization signal to transfect a plasmid expressing full-length HDM-2 into PNC-27-insensitive untransformed MCF-10-2A cells and found that these cells expressed full-length HDM-2 on their cell surface. cells versus PNC-27. We concluded that PNC-27 targets HDM-2 in cancer cell membranes, allowing it to selectively induce membrane lysis in these cells.
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Products Description
peptide is a high-quality product designed to meet the needs of businesses looking to healthcare. This product offers a range of features and benefits that make it an ideal choice for businesses of all sizes.
Features:
We could offer various types of peptides. about peptides, We can offer good quality and good price for petides.
Benefits:
We can provide you stable quality, high purity, good packaging at most competitive price. The products can be sent to USA, Canada, Australia, Europe … with special package or shipping way which can ensure high success rate of customs. The payment will be 100% refunded if the parcel is not delivered or poor quality.
We believe that polypeptide offers an unbeatable combination of quality, performance, and value. If you have any questions about this product or would like to learn more about how it can benefit your business, please don't hesitate to contact us. We are dedicated to providing excellent customer service and helping our customers achieve their business goals.
Thank you for considering polypeptide We look forward to the opportunity to work with you and help you achieve success.
1. How to make an order?
Send me message and let me know what you need with quantity , then i will calculate to you
2. What's the lead time and shipping ways?
We will delivery to the package by FEDEX express to you after receive your payment, it would take around 5-7 days to your address.
3. How do i keep the peptides when i receive it ?
Peptides in the form of lyophilized powder can be transported at room temperature by vacuum packaging, while polypeptides in the dissolved state need to be refrigerated at 2°C - 8°C. For long-term storage, peptides should be stored in the form of lyophilized powder store at -20°C or -80°C in a sealed container with desiccant, which can avoid the degradation of peptides to the greatest extent.
4. What's the payment methods?
We could accept pay through paypal,bank transfer, X-Transfer and bitcoin.
——Handling and Storage——
Precautions for safe handling:Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.Conditions for safe storage, including any incompatibilitiesStore the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
——— Company Profile ———
We are a chemical manufacturer integrating production, processing and export, mainly dealing in pharmaceutical intermediates and various industrial chemicals. It has won praise from customers at home and abroad. We have also established an excellent professional sales team with rich international marketing experience, able to efficiently provide a range of products and professional services.
With synthetic biology platform technology as the core, it conducts innovative research and development, mainly engaged in the research and development of recombinantly expressed pharmaceutical peptides and proteins. Its products include innovative drugs, APIs, pharmaceutical and green synthetic industrial enzymes, functional peptides and protein products, etc.
At present, our company has realized the industrialization of a variety of biosynthetic peptide products and has obtained cooperation orders from many well-known domestic and foreign pharmaceutical companies.
| Items | Specifications |
| CAS number | 1159861-00-3 |
| Purity | 99% |
| Molecular Weight | 4813.527g/mol |
| Appearance | White powder |
| Storage | Dry and Cool Place, Frozen |
| Grade | Pharmaceutical Grade |
| Specification | 5mg 10mg |