Semax Selank peptide N-acetyl-Met-Glu-His-Phe-Pro-Gly-Pro-NH2 CAS 80714-61-0 Research Peptide Lab Reagent

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Semax (CAS 80714-61-0) Product Introduction

Semax is a synthetic linear heptapeptide, an analog of ACTH (4-10), with the amino acid sequence Met-Glu-His-Phe-Pro-Gly-Pro. Its CAS registry number is 80714-61-0, its molecular formula is C₃₇H₅₁N₉O₁₀S, and its molecular weight is 813.90 Da. Unlike the natural ACTH fragment, this modified peptide eliminates endocrine hormone activity while retaining significant neurotrophic activity, making it a commonly used biochemical reagent in academic laboratories and biotechnology research institutions worldwide. We offer Semax as a white lyophilized powder, produced using standardized peptide synthesis and purification processes, with HPLC-verified purity ≥99.0%. All batches undergo rigorous quality inspection and a Certificate of Analysis (COA) containing chromatographic data is available to support customer experimental validation. In preclinical studies, Semax has demonstrated a variety of biological effects closely related to the nervous system. One of its core mechanisms is the upregulation of brain-derived neurotrophic factor (BDNF) and TrkB receptor expression, thereby promoting neuronal survival, accelerating synaptic remodeling, and improving neuronal plasticity. Furthermore, this compound exhibits significant antioxidant and anti-inflammatory properties. It can alleviate oxidative stress damage in neural tissue, inhibit the release of pro-inflammatory factors, suppress neuronal apoptosis, and maintain the integrity of the blood-brain barrier. Multiple laboratory studies have also confirmed that Semax can regulate the secretion levels of major neurotransmitters, including acetylcholine, dopamine, and serotonin, thereby modulating information transmission within the central nervous system. Unlike many macromolecular biologics, Semax possesses excellent transmembrane properties, enabling it to efficiently reach target neural tissues after administration in research models.

Currently, Semax is widely used in various preclinical research areas. Current research on Semax primarily focuses on brain injury models, including ischemic stroke, transient ischemic attack, and traumatic brain injury. Researchers are using Semax to explore intervention strategies to reduce neurological function loss after brain injury. Secondly, it is also used as a tool in cognitive function research. Numerous animal studies have investigated the potential effects of Semax on learning ability, memory maintenance, and attention. Furthermore, Semax is frequently used in exploratory research on neurodegenerative diseases, optic nerve protection, and neuroimmunology. It is particularly important to emphasize that the Semax provided by our company is only for research laboratory experiments. Related research results cannot be directly interpreted as therapeutic effects, and this product may not be used for human injection, oral administration, or any clinical treatment without full drug approval.

The Semax lyophilized powder provided by our company meets the standard specifications for research-grade peptide products. During the production process, all indicators are strictly controlled: single impurity content ≤7.0%, total impurity content ≤1.0%, moisture content ≤5.0%, heavy metal content ≤10 ppm, and bacterial endotoxin content ≤10 EU/mg. Residual solvents comply with ICH Q3A guidelines to avoid interference with cell and animal experiments. The product is vacuum lyophilized and sealed in glass vials to reduce the risk of degradation during transportation. Standard packaging specifications include 5mg, 10mg, and other customized specifications to meet the needs of small-scale trials and laboratory bulk purchases.

Proper storage is crucial for ensuring the long-term stability of Semax. We recommend storing sealed lyophilized powder at -20°C in the dark. Repeated freeze-thaw cycles must be avoided to prevent peptide denaturation. After dissolving in laboratory water, aqueous solutions should be prepared fresh. Unused liquid solutions can be stored short-term at 2–8°C, but long-term storage of dissolved samples is not recommended. During handling, standard laboratory protective equipment, such as gloves and goggles, should be worn to avoid direct contact with skin and eyes.

Disclaimer: This product is for laboratory research use only. It is not a pharmaceutical product, is not intended for human or animal clinical use, and must not be processed as a pharmaceutical raw material without relevant national certification. The buyer is solely responsible for controlling the use of this product in accordance with local laws and regulations.

  We are a chemical manufacturer integrating production, processing and export, mainly dealing in pharmaceutical intermediates and various industrial chemicals. Since its establishment, the company adheres to the spirit of "integrity management, strict quality control, customer first", and has won praise from customers at home and abroad.  We have also established an excellent professional sales team with rich international marketing experience, able to efficiently provide a range of products and professional services.

    With synthetic biology platform technology as the core, it conducts innovative research and development, mainly engaged in the research and development of recombinantly expressed pharmaceutical peptides and proteins. Its products include innovative drugs, APIs, pharmaceutical and green synthetic industrial enzymes, functional peptides and protein products, etc.

    At present, our company has realized the industrialization of a variety of biosynthetic peptide products and has obtained cooperation orders from many well-known domestic and foreign pharmaceutical companies.