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High quality 99% Retatrutide lyophilized powder in stock sema/tirz weight loss peptide with 20mg buy - image1

High quality 99% Retatrutide lyophilized powder in stock sema/tirz weight loss peptide with 20mg buy - image2

High quality 99% Retatrutide lyophilized powder in stock sema/tirz weight loss peptide with 20mg buy - image3

High quality 99% Retatrutide lyophilized powder in stock sema/tirz weight loss peptide with 20mg buy - image4

High quality 99% Retatrutide lyophilized powder in stock sema/tirz weight loss peptide with 20mg

Name: High quality 99% Retatrutide lyophilized powder in stock sema/tirz weight loss peptide with 20mg
Brand: Novio
SKU: pr2609072009
Price: 103 USD
Availability: InStock

TDS 6924 Inquiries

Unit Price:

$103/UNIT FOB

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CAS No.:

2381089-83-2

Grade:

Pharmaceutical Grade

Content:

99%

Port:

HongKong

Brand:

Novio

Packaging:

20mg 10vials

Price valid (until):

2026-10-07

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Beijing Novio Biotechnology Co., Ltd.

Company Type:

Trader

Location:

China

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Main Products:

Peptides,Cosmetic Raw Materials,Pharmaceutical Intermediates

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Product Description
Seller Information
Inquiry History

Description

Product Detail

WhatsApp: +852 9335 4794

Email: 15030963274@163.com

Retatrutide, with the research code LY-3437943, is a novel synthetic triple receptor agonist peptide, consisting of 39 modified amino acids. It has a molecular formula of C₂₂₁H₃₄₂N₄₆O₆₈ and a molecular weight of 4731.33 Da. Our product is supplied as a research-grade lyophilized powder, FOR LABORATORY RESEARCH USE ONLY, not for human clinical use, treatment, diagnosis, or veterinary administration. It is widely supplied to pharmaceutical R&D institutions, university laboratories, and biotechnology companies for research on metabolic disease mechanisms, peptide drug development, in vitro cell assays, and related pharmacological model exploration, serving as a key research tool in the booming field of metabolic disorder research.
This product appears as a white to off-white lyophilized powder, manufactured via mature solid-phase peptide synthesis technology with multiple purification steps. It has a purity of ≥98% tested by HPLC, and complete COA and MS verification documents are available to ensure batch-to-batch stability and reproducible experimental data. The product has good water solubility, dissolvable in pure water and PBS buffer, facilitating the preparation of working solutions for in vitro and in vivo studies. The molecular structure is modified with a fatty acid side chain, which effectively extends the molecular half-life, delivering excellent metabolic stability in experimental systems, reducing frequent dosing operations and improving research efficiency.
Retatrutide acts as a triple agonist targeting GLP-1R, GIPR, and GCGR simultaneously, providing synergistic effects through multiple pathways that distinguish it from single or dual-target peptide agonists. Activation of GLP-1R promotes glucose-dependent insulin secretion, suppresses appetite, and delays gastric emptying; GIPR activation optimizes insulin secretion and enhances insulin sensitivity; GCGR is involved in regulating energy expenditure and glucose-lipid metabolism. Its EC50 values for human GCGR, GIPR, and GLP-1R are 5.79 nM, 0.0643 nM, and 0.775 nM respectively, with clear target activity data, making it ideal for research on receptor binding, signal pathways, and animal models of obesity and type 2 diabetes. Extensive literature studies have confirmed that this compound regulates food intake, improves glucose tolerance, and modulates multiple metabolic indicators in animal models, providing critical support for the development of novel metabolic drug candidates.
We offer multiple packaging specifications including 5mg, 10mg, 15mg, 20mg, 30mg,40mg,50mg,to meet the needs from small-scale trial research to large-volume project procurement. For storage, the lyophilized powder should be kept sealed, light-proof, and moisture-free at -80°C for long-term storage (24 months validity), or at -20°C for 12 months. After reconstitution into solution, aliquot storage at -80°C is recommended to avoid activity loss caused by repeated freeze-thaw cycles. The product is shipped with low-temperature protective packaging, with full light and moisture protection to ensure product quality upon arrival. After receipt, please store it in a low-temperature environment as soon as possible, and open the vial in a dry inert gas environment to prevent moisture absorption and degradation.
Strict quality control is implemented throughout the production process, with manufacturing conducted in cleanroom facilities. Each batch is tested for key indicators including HPLC purity, molecular weight confirmation by MS, appearance, and moisture content. Complete quality inspection documents are provided with the product or upon request. As a reliable supplier serving the global B2B chemical and research market, we support sample orders and bulk orders, adapting to the procurement needs of universities, research institutes, CROs, and biological laboratories.
Important Notice: This product is FOR RESEARCH USE ONLY. Not for human, veterinary, therapeutic or diagnostic use. All experimental operations must comply with local laboratory safety regulations.

Items Specifications

Generic Name Retatrutide

Drug Type GLP‑1/GIP/GCGR

Purity (HPLC) ≥99.0%

FAQ

Q1: About the after-sale service

A: After purchasing the products from our Lab, we have A professional technical team and after-sales team to serve you and solve all your problems in the future

Q2: Do you have stock?

A: We understand most customers prefer stock, so we'll try to keep stock for most products. However, for some rare products, we won't keep stock and it needs time to synthesize.

Q3: How do I start paying?

A:Payment can be made by Bitcoin,wire transfer or paypal

Q4: How to confirm product quality before placing an order?

A: We got good feedback from customers and Tested by third-party institutions. You also can get free samples of some products. You just have to pay the shipping fee for the sample . You can send us your product specifications and requirements and we can customize for you.

Q5: What is your MOQ?

A: The minimum quantity we can order is 1 box. But usually we can accept a smaller quantity, say 100g, at the cost of 100% sample charge.

Q6: Time for delivery?

A: Leading time within 3 business days,Shipping time about 8-10 business days.

Q7: Why should I choose you?

A: Powerful technical support-come from our highly skilled & fully experienced staff, working in chemical industry for over 5years, in average.Strict quality control-comes form our sophisticated management system.Professional and warm sales team-since we believe we can only win via our hard work in a competitive world.Quick response and excellent presale and after sale service-since we believe our customers deserve all the best service.

ECHEMI Editorial Reference

Retatrutide is a novel triple agonist peptide of the glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR) and glucagon-like peptide-1 receptor (GLP-1R). Retatrutide inhibits human GCGR, GIPR and GLP-1R with EC50 values of 5.79, 0.0643 and 0.775 nM, respectively and mouse GCGR, GIPR, and GLP-1R with EC50 values of 2.32, 0.191 and 0.794 nM, respectively. It is an important tool for obesity research.Retatrutide potently activates the GLP-1R signaling pathway to stimulate glucose-dependent insulin secretion through activity at the GIP receptor (GIPR) or the GLP-1R.Retatrutide is a synthetic peptide with glucose-lowering effects. It is an antidiabetic agent against type 2 diabetes (T2D), stimulating insulin and suppressing glucagon secretion in a glucose-dependent manner.Retatrutide was also shown to delay gastric emptying, lower fasting and postprandial glucose concentration, decrease food intake and reduce body weight in patients with type 2 diabetes.

Certificates
- TDS
Basic Info

Product Name:
Retatrutide

Other Name:
Retatrutide;GIPR/GLP-1R;LY3437943Retatrutide;Retalutide;Retatrutide (sodium salt);Retatrutide RT5;retatrutide 5mg;Retatratide

CAS No.:
2381089-83-2

Molecular Formula:
C221H342N46O68

InChIKeys:
MLOLQJNKXBNWFW-SAGGEDDASA-N

Molecular Weight:
4731.33

EC Number:
200-001-8

Color/Form:
White lyophilized

Categories:
Bulk Drug Intermediates

Characteristics

Water Solubility:
Soluble in water (5mg/ml).

Storage Conditions:
-20°C

Critical Temperature & Pressure:
-20°C

Research

Class:
Triple agonist — GCGR, GIPR, GLP-1R

Status:
Investigational (Phase 3)

Mechanism:
Simultaneously activates glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R). Engineered from the native GIP backbone with amino acid substitutions to confer GCGR and GLP-1R activity.

EC50 (Human GCGR):
5.79 nM

EC50 (Mouse GIPR):
0.191 nM

EC50 (Mouse GLP1R):
0.794 nM

EC50 (Mouse GCGR):
2.32 nM

EC50 (Human GLP1R):
0.775 nM

EC50 (Human GIPR):
0.0643 nM

Source:
Jastreboff AM, et al. N Engl J Med. 2023;389(6):514-526.DOI

Clinical Development:
NCT04881760; NCT05882045; NCT06354660

References

ChEMBL:
CHEMBL5095485

DrugBank:
DB18993

KEGG DRUG:
D12430

PubChem:
PubChem

Literature:
NEJM: Jastreboff et al. (2023) — Phase 2 Trial; FDA Drugs@FDA

Disclaimer:
Retatrutide is an investigational compound not yet approved by FDA or EMA. This listing is for industrial and laboratory research use only. Product information on ECHEMI is provided for sourcing and specification reference. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.

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Seller Information

Business Type:
Trader

Main Products:
Peptides,Cosmetic Raw Materials,Pharmaceutical Intermediates

Location:
Room 1359, Room 103, Building Jia 19, Jixiang Garden, Tongzhou District, Beijing

Year of Establishment:
2026

Inquiry History

6924 Inquiries

Country	Product	Purchase Quantity	Date Posted
United States	Retatrutide 2381089-83-2	3 MT	Mar 28, 2026
United Kingdom	Retatrutide - 2381089-83-2	1 G	Feb 10, 2026
United States	Retatrutide CAS 2381089-83-2 10mg vial	20 MT	Mar 7, 2026
United States	Factory Retatrutide API 99% Purity CAS 2381089-83-2	5 KG	Nov 10, 2025
United Kingdom	Peptide powder Retatrutide 99% pure for Body building cas 2381089-83-2 Weight Loss Peptide with COA	1 MT	Mar 22, 2026
United States	2381089-83-2	100 G	Jul 14, 2026
United States	2381089-83-2	100 G	Feb 24, 2026
United States	2381089-83-2	100 MT	Dec 9, 2023
United States	Retatrutide 2381089-83-2	200 MG	May 16, 2026
United Kingdom	2381089-83-2 retatrutide	300 MG	Feb 13, 2026
United States	Retatrutide 2381089-83-2 wholesale	500 MT	Nov 3, 2023
Poland	CAS 2381089-83-2 (Custom Peptide)	40 MT	Apr 10, 2026
Austria	Peptide Retatruide CAS 2381089-83-2	100 MT	Apr 4, 2026
United States	Retatrutide CAS 2381089-83-2 99%	10 PCS	Feb 21, 2026
Austria	Retatrutide CAS 2381089-83-2 10mg vial	20 PCS	Feb 10, 2026
United States	GLP-1 / GIP Retatrutide cas 2381089-83-2	1 MT	Oct 16, 2024
United States	Retatrutide 99% High Quality CAS 2381089-83-2	1 G	Jan 23, 2026
United States	Injection Peptide Tirzepatide/Retatrutide/ Semaglutide Peptides CAS 2381089-83-2	10	Oct 21, 2023
Australia	GMP Grade 99% Retatrutide Lyophilized Powder CAS 2381089-83-2	10 G	Jun 12, 2026
Palestine	Factory 99% Purity Retatrutide Peptide CAS 2381089-83-2 Door-To-Door Service	10 MG	Mar 16, 2026

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Items	Specifications
Generic Name	Retatrutide
Drug Type	GLP‑1/GIP/GCGR
Purity (HPLC)	≥99.0%

High quality 99% Retatrutide lyophilized powder in stock sema/tirz weight loss peptide with 20mg

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