Supply High Purity Cortagen (AEDP Tetrapeptide) CAS 83270-84-2 | Peptide Bioregulator for R&D

Cortagen More Info

Cortagen is a synthetic tetrapeptide with the amino acid sequence Ala-Glu-Asp-Pro (AEDP), developed through directed synthesis based on the amino acid analysis of the natural brain cortex peptide preparation Cortexin. With the CAS number 83270-84-2, this compound has a molecular formula of C17H26N4O9 and a molecular weight of approximately 430.41 g/mol, and is typically supplied as a high-purity white to off-white powder for research applications. It is recognized as a peptide bioregulator with a primary focus on neurobiological and gerontological research.

The proposed mechanism of Cortagen involves epigenetic modulation at the chromatin level. Studies have demonstrated that it can induce deheterochromatinization, a process that unrolls densely packed chromatin and reactivates genes that have been silenced due to age-related condensation. This chromatin-remodeling activity is proposed as an upstream mechanism through which Cortagen influences downstream gene expression across multiple tissue types, distinguishing it from single-target pharmacological agents.

Preclinical research has characterized Cortagen's effects across several biological systems. A notable microarray study in mouse heart tissue identified differential expression in over 110 known genes following Cortagen administration, with changes ranging from +5.42 to -2.86 fold. These affected genes belonged to various functional categories, including cellular stress responses, apoptosis regulation, signal transduction, and tissue repair, indicating broad transcriptomic modulation. Additionally, Cortagen has been shown to modulate interleukin-2 gene expression in immune cells and exert neuroprotective effects in models of peripheral nerve damage.

In neurobiological research, Cortagen has demonstrated a pronounced effect on the structural and functional recovery of damaged peripheral nerve tissue. Electrophysiological studies have shown that it can moderately influence neuronal membrane potential and increase impulse activity at certain concentrations, while higher concentrations reversibly affect sodium and calcium channel currents. These findings support its classification as a neuroactive peptide bioregulator with potential applications in research areas such as ischemic brain injury recovery, neuroinflammation regulation, and age-related cognitive support.

Cortagen is one of several short peptides developed within the Khavinson bioregulator program at the St. Petersburg Institute of Bioregulation and Gerontology. It is important to note that while the compound has a substantial body of Russian preclinical and small clinical literature, it is not approved for medical use in major Western regulatory jurisdictions and is supplied exclusively as a research-use-only compound. Material is commonly available in research quantities (1g, 10g, 100g) and bulk packaging, and should be stored in a well-closed container, protected from light, in a cool and dry environment.

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