High Quality EP/BP Standard Ketotifen fumarate 34580-14-8 with ready stock and fast delivery

Ketotifen fumarate More Info

Ketotifen fumarate is a pharmacological agent primarily used as an antihistamine and mast cell stabilizer. It is effective in managing allergic conditions such as allergic conjunctivitis, asthma, and urticaria (hives). The drug is available in various formulations, including oral tablets and ophthalmic solutions.

Mechanism of Action

Ketotifen exerts its effects through multiple mechanisms:
Histamine H1 Receptor Antagonism: It acts as a non-competitive antagonist at the H1 receptor, preventing the action of histamine, a key mediator in allergic responses.
Mast Cell Stabilization: Ketotifen inhibits the release of inflammatory mediators from mast cells, including histamine and leukotrienes, thereby reducing the severity of allergic reactions.
Inhibition of Eosinophil Activation: It prevents the accumulation and activation of eosinophils in allergic conditions, which contributes to inflammation and tissue damage.
These combined actions make ketotifen effective in alleviating symptoms associated with allergies and asthma.

Applications

Ketotifen fumarate is indicated for:
Allergic Conjunctivitis: Used to relieve itching and redness of the eyes caused by allergies.
Asthma Management: As an adjunct therapy to reduce the frequency and severity of asthma attacks.
Urticaria (Hives): Effective in managing symptoms associated with chronic urticaria.
Other Allergic Conditions: Such as allergic rhinitis and dermatitis.

Routes of Administration

Ketotifen fumarate is available in several forms:
Oral Tablets: Commonly prescribed for systemic use in managing allergies and asthma.
Ophthalmic Solution: Used for localized treatment of allergic conjunctivitis.
The typical dosage for oral administration ranges from 1 mg to 2 mg twice daily, while the ophthalmic solution is usually applied as one drop in each affected eye twice daily.

Safety and Side Effects

Common Side Effects
Patients using ketotifen may experience:
Drowsiness or sedation
Dry mouth
Nausea
Headache
Eye irritation (for ophthalmic formulations)
Serious Side Effects
More severe adverse effects can include:
Allergic Reactions: Symptoms such as rash, itching, swelling, or difficulty breathing.
Severe Dizziness or Fainting: Indicating potential cardiovascular effects.
Liver Dysfunction: Rarely reported but may manifest as jaundice or elevated liver enzymes.
Precautions
Caution is advised for individuals with a history of liver disease or those taking other medications that may interact with ketotifen. Regular monitoring is recommended during treatment.

Pharmacokinetics

Absorption and Distribution
Ketotifen is well absorbed from the gastrointestinal tract after oral administration, with peak plasma concentrations reached within 2 to 4 hours. The bioavailability is approximately 50% due to first-pass metabolism.
Metabolism and Excretion
The drug undergoes hepatic metabolism and is primarily excreted through urine. The elimination half-life is about 12 hours, allowing for convenient dosing schedules.
Special Considerations
Patients should be aware that ketotifen may cause drowsiness; therefore, caution should be exercised when driving or operating machinery until they know how it affects them.

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FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

Q2. What is the HyperChem payment term?

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Q3. What is HyperChem shipment policy?

Our policy is to strive for the quickest shipment time possible.

For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

Q4. What is HyperChem shipment term?

By Express  
FedEx  UPS  DHL  EMS                               
Fast: 3-7 days around, high cost, door to door service

By Air                                        
Suitable for more than 50kg 
Fast: 3-7 days, hight cost, port to port, professional broker needed 

By Sea
Suitable for more than 500kg      
Fast: 7-45 days, low cost, port to port, professional broker needed 

We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. What HyperChem will provide after shipment?

For sample orders: 
After shipment is done, an timely email including:

1. Track details (Fedex /TNT/DHL/EMS Track number)
2. Packaging photo
3. COA, MSDS, etc
4. Dispatch date & Estimated arriving time
5. Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

Company Profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

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HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.