Scheffoleoside A 98% Purity Natural Product Reference Standard CAS 160669-23-8 Research Grade Triterpenoid Saponin Neuroprotective Agent

Product Overview

Scheffoleoside A is a naturally occurring oleanane-type triterpenoid saponin derived from Centella asiatica (Gotu Kola), a medicinal plant widely used in traditional medicine systems across Asia. It is characterized by an asiatic acid aglycone esterified at the C-28 position with a complex trisaccharide chain composed of rhamnose and glucose units.

• Molecular Formula: C₄₈H₇₈O₁₉

• Molecular Weight: 959.12 g/mol

• Appearance: White crystalline powder

• Solubility: Soluble in methanol, DMSO, and pyridine

• Biological Activities & Research Significance

• Neuroprotective Effects: Exhibits moderate neuroprotective activity against 6-hydroxydopamine (6-OHDA)-induced cytotoxicity in PC12 cells, a classic Parkinson's disease cellular model

• Reference Standard for SAR Studies: Directly comparable with 11-oxo-asiaticoside B, which showed 91.75% cell viability at 100 µM. Essential for structure-activity relationship studies of neuroprotective saponins

• Pharmacokinetic Marker: Unique MRM transition enables interference-free quantification in biological matrices, particularly valuable for pharmacokinetic studies of Centella asiatica and Akebia trifoliata extracts

Research Applications

• Neuroprotection and Parkinson's disease research

• Quality control reference for Centella asiatica extracts

• Pharmacokinetic studies

• Structure-activity relationship studies of triterpenoid saponins

Quality Specifications

• Purity: ≥98.0% determined by HPLC

• Appearance: White crystalline powder

• Identification: Confirmed by NMR and MS

• Storage: -20°C (powder); -80°C in solvent

• Each batch accompanied by comprehensive Certificate of Analysis (COA)

Packaging & Storage

• Packaging: 5mg, 10mg, 20mg, 50mg, 100mg, 500mg, 1g amber glass vials

• Long-term storage: -20°C, protected from light and moisture

• Stability: ≥2 years under proper storage conditions

• Shipping: Shipped with ice pack

Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.

Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.

We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.

To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.

Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers.