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Fast DDP Shipping 99% Purity Raw Powder Factory Supply Mazdutide Peptides Powder Mazdutide for Weight Loss with 5mg

Name: Fast DDP Shipping 99% Purity Raw Powder Factory Supply Mazdutide Peptides Powder Mazdutide for Weight Loss with 5mg
Brand: Novio
SKU: pr2609101560
Price: 95 USD
Availability: InStock

TDS 5 Inquiries

Unit Price:

$95/UNIT FOB

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CAS No.:

2259884-03-0

Grade:

Pharmaceutical Grade

Content:

99%

Port:

HongKong

Brand:

Novio

Packaging:

5mg*10vials

Price valid (until):

2026-10-10

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Beijing Novio Biotechnology Co., Ltd.

Company Type:

Trader

Location:

China

Qualification:

Main Products:

Peptides,Cosmetic Raw Materials,Pharmaceutical Intermediates

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Product Description
Seller Information
Inquiry History

Description

Product Detail

WhatsApp: +852 9335 4794

Email: 15030963274@163.com

Mazdutide is an innovative therapeutic agent with the following details:
English name: Mazdutide

CAS number: 2259884-03-0

Mazdutide is a GLP-1R/GCGR dual receptor agonist developed by Innovent Biologics, intended for the long-term weight management of adult patients with obesity or overweight.

Mechanism of Action

Mazdutide innovatively adopts a dual receptor agonist mechanism. On one hand, it activates GLP-1R to promote insulin secretion, suppress appetite, and delay gastric emptying, thereby reducing food intake. On the other hand, it activates GCGR to promote fat oxidation and energy expenditure. This two-pronged approach enhances the ability to reduce weight and regulate metabolism.

Weight Loss Efficacy

In the Phase II clinical trial of Mazdutide, patients in the 3mg, 4.5mg, and 6mg Mazdutide groups (administered once weekly) achieved an average weight reduction of 7.2%, 10.6%, and 11.6% respectively after 24 weeks of treatment. Results from the Phase III GLORY-1 trial showed that during the 48-week treatment period, the 6mg Mazdutide group had an average weight loss of 14.01%, while the placebo group only had a weight loss of 0.30%.

Improvement of Metabolic Indicators

Mazdutide not only effectively reduces weight but also comprehensively improves metabolic indicators. For example, in the Phase III clinical trial, the 6mg Mazdutide group saw an average reduction of 8.56mmHg in systolic blood pressure, a decrease of 0.65mmol/L in triglycerides, and a significant reduction in uric acid levels. Additionally, it showed a significant improvement effect on fatty liver, which can effectively reduce the pressure on the cardiovascular system and lower the risk of obesity-related complications.

Target Population

It is suitable for patients with simple obesity (BMI ≥ 28) and patients with a BMI of ≥ 24 who have one or more comorbidities, such as hyperglycemia, hypertension, dyslipidemia, fatty liver, and obstructive sleep apnea.

Mazdutide (brand name: Xinelem®) is a global first and the first to be approved for market use, a dual receptor for glucagon (GCG) and glucagon-like peptide-1 (GLP-1), belonging to a long-acting synthetic gastrin-releasing peptide (OXM) analog.
Core efficacy
1. Significant weight loss effect
In overweight/obese adults, a 6 mg dose treatment for 48 weeks resulted in an average weight loss of 14.01%, and some patients achieved a maximum reduction of 21% (high dose 16 mg, in clinical trial stage)
The proportion of patients with weight loss ≥ 5%: 82.8% in the 6 mg group (vs 11.5% in placebo)
The average reduction in waist circumference: 10.96 cm (6 mg group)
2. Improved blood glucose control (applicable to type 2 diabetes)
After 24 weeks of treatment, glycated hemoglobin (HbA1c) decreased by 2.15% (6 mg group), superior to placebo (-0.14%) and dulaglutide
In patients with type 2 diabetes combined with obesity, 48% of patients achieved the dual goals of HbA1c < 7.0% and weight loss ≥ 10%, significantly better than semaglutide (21%)
3. Improved liver fat metabolism
For patients with baseline liver fat content ≥ 10%, liver fat content decreased by 80.2% after 48 weeks of treatment
Significantly increased the proportion of liver fat returning to normal (< 5%)
Multiple metabolic benefits
Blood pressure: Systolic blood pressure decreased by approximately 6.75 mmHg
Blood lipids: Triglycerides ↓ 0.52 mmol/L, total cholesterol ↓ 0.45 mmol/L, LDL-C ↓ 0.31 mmol/L

Items	Specifications
product name	Mazdutide
CAS number	2259884-03-0
Purity	99%
Appearance	White powder

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ECHEMI Editorial Reference

Mazdutide is a peptide-based GLP-1 and glucagon receptor (GCGR) dual agonist. As a pharmaceutical raw material, Mazdutide is characterized by its dual receptor activity and defined peptide structure. It is suitable for API research, analytical testing, pharmaceutical development, and related manufacturing processes.

Certificates

Basic Info

Product Name:

Mazdutide

Other Name:

Mazdutide;Mazdutide acetate;Mazdutide 10mg;Mazdutide 5mg 10mg;LY-3305677;Mazdutide (IBI-362;OXM-3)

CAS No.:

2259884-03-0

Molecular Weight:

EC Number:

884-103-0

Color/Form:

White to off-white

Categories:

Bulk Drug Intermediates

Research

Class:

Dual GLP-1R/GCGR agonist (long-acting peptide)

Status:

Investigational — Phase 3 (China)

Mechanism:

A long-acting dual agonist of the GLP-1 receptor (GLP-1R, Ki = 28.6 nM) and glucagon receptor (GCGR, Ki = 17.7 nM). The dual activation provides both glycemic control (via GLP-1R) and increased energy expenditure / hepatic lipolysis (via GCGR), producing weight loss beyond what GLP-1R agonism alone achieves. Administered once weekly.

EC50 (GLP1R Ki):

28.6 nM

EC50 (GCGR Ki):

17.7 nM

Source:

GlpBio: Mazdutide (CAS 2259884-03-0); Innovent Phase Ib results (eClinicalMedicine 2022).DOI

Clinical Development:

NCT04930343; NCT05592656

References

PubChem:

PubChem

Literature:

GlpBio: Mazdutide (CAS 2259884-03-0); eClinicalMedicine: Innovent Phase Ib results (2022); ClinicalTrials.gov: DREAMS-1 (NCT04930343)

Disclaimer:

Mazdutide is NOT FDA-approved or EMA-approved. It is in Phase 3 clinical trials in China. This listing is for industrial and laboratory research use only. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.

Seller Information

Business Type:
Trader

Main Products:
Peptides,Cosmetic Raw Materials,Pharmaceutical Intermediates

Location:
Room 1359, Room 103, Building Jia 19, Jixiang Garden, Tongzhou District, Beijing

Year of Establishment:
2026

Inquiry History

5 Inquiries

Country	Product	Purchase Quantity	Date Posted
United States	Mazdutide	25 MG	Aug 12, 2026
Nigeria	Mazdutide 10mg	20 PCS	Mar 7, 2026
United States	Mazdutide	30 MG	Jul 15, 2024
United Kingdom	Mazdutide	1 KG	Feb 10, 2026
United States	Mazddultide cas	2 MT	Nov 14, 2025

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