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Liver Health Natural Silymarin Silybin Isosilybin Milk Thistle Extract

Name: Liver Health Natural Silymarin Silybin Isosilybin Milk Thistle Extract
Brand: ONERBIO
SKU: pr2609141261
Price: 10 USD
Availability: InStock

TDS 4 Inquiries

Unit Price:

$10-11/KG FOB

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CAS No.:

84604-20-6

Grade:

Pharmaceutical Grade

Content:

99%

Port:

Shanghai

Brand:

ONERBIO

Packaging:

25kg/drum

Price valid (until):

2026-10-14

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Wuhan Oner Biotech Co.,Ltd.

Company Type:

Distributor

Location:

China

Payment Terms:

TT against copy of documents

Average Lead Time:

5 days

Qualification:

Main Products:

Nutrition supplement material,Pharmaceutical raw material,Chemical raw material

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Product Description
Seller Information
Inquiry History

Description

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Milk Thistle Extract

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Product Specification: 80% silymarin, 30% silybin, 40% Silymarin(water soluble）
Latin Name: Silybum Marianum (L.) Gaertn
Test Method: UV, HPLC

Milk Thistle Extract

Milk Thistle Extract is a natural active substance extracted from the dried ripe fruits of Silybum marianum (Asteraceae), with Silymarin as its key component and Silibinin as the main active ingredient. It features strong antioxidant and anti-inflammatory properties, protects liver cell membranes, and promotes hepatocyte repair and regeneration. As a classic liver-protective ingredient, it is widely used in pharmaceuticals, dietary supplements and functional foods. It also serves as a green and safe animal feed additive to improve liver function, enhance stress resistance and immunity, and boost production performance in livestock, poultry and aquaculture.

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Milk thistle extract is widely used in medicine, health products, food and cosmetics, feed additives.

◆ Protecting liver cell membrane and improving the liver function.

◆ Detoxification, reducing the blood fat, benefiting the gallbladder, protecting the brain and removing the free radical of body. As a kind of better antioxidant, it can clear free radical in human body, postpone senility.

◆ Silymarin extract has the function of radiation hardening, arteriosclerosis preventing, and skin-aging.

◆ Silymarin has functions such as improving animal growth performance, protecting the liver, regulating metabolism, clearing free radicals, and antioxidation.

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Ingredient name	Milk Thistle Extract (Silybum marianum seed extract)
Synonyms	Silybum marianum extract; milk thistle seed extract; St. Mary’s thistle extract; Carduus marianus extract; silymarin extract
CAS number	84604-20-6 (Silybum marianum extract). Standardization marker complex: silymarin, CAS 65666-07-1.
Molecular formula / weight	Not applicable — multi-constituent botanical extract. Silymarin is itself a flavonolignan complex (silybin A and B, isosilybin, silychristin, silydianin) rather than a single compound, so no single molecular formula or molecular weight describes the material. Identity is established by botanical source, plant part and marker profile.
Botanical identity	Silybum marianum (L.) Gaertn., family Asteraceae. Plant part: fruit and seed (achene). Identity confirmed by macroscopic, microscopic and chromatographic (HPLC or TLC) comparison against a reference; identity documentation supplied per lot.
Standardization / assay	Standardized to an agreed silymarin content, reported both by UV and by HPLC on the Certificate of Analysis for each lot. The exact grade is specified per order; grade options available on request. The two figures are not interchangeable: UV-spectrophotometric silymarin and HPLC sum-of-flavonolignans measure the material differently, so the same lot reads differently by each method. Because both are reported per lot, the buyer can align the incoming release specification to whichever method their own monograph or customer specification is written against, without re-testing.
Extraction ratio and solvent	Extraction ratio (e.g. drug-to-extract ratio) and extraction solvent are specified per order and stated on the specification sheet. Residual solvent results are reported per lot against the applicable pharmacopoeial limits.
Carrier / excipient declaration	Any carrier used for standardization or flowability (for example maltodextrin or silicon dioxide) is declared on the specification sheet with its inclusion level, so that the buyer’s label and allergen statement can be built correctly.
Appearance	Light yellow to yellowish-brown fine powder, characteristic odour and bitter taste
Solubility	Flavonolignans are practically insoluble in water and soluble in ethanol, methanol and acetone. Water-dispersible and solubility-enhanced formats are handled as separate specifications; dissolution behaviour should be confirmed for the intended dosage form.
Stability / storage	Store in tightly closed containers in a cool, dry place, protected from light and moisture. Flavonolignans are sensitive to prolonged heat, high humidity and light; stability data available on request.
Typical applications	Capsules, tablets, softgels, powder blends and sachets for B2B nutraceutical manufacturing; commonly formulated alongside NAC, TUDCA, dihydromyricetin and artichoke extract

For regulatory compliance (e.g., USP, EP, JP), raw material Vidarabine must meet several rigorous standards:

Assay (by HPLC): 98.0% – 102.0% on an anhydrous basis.
Related Substances: Limits for specific impurities, notably Ara-Hx (NMT 2.0%), as well as any unspecified individual impurity (NMT 0.1%) and total impurities (NMT 2.0%).
Residual Solvents: Must comply with ICH Q3C guidelines (Class 1 and 2 solvents limited or absent).
Heavy Metals: NMT 20 ppm (typically lower for injectable grades).
Water Content (Karl Fischer): NMT 6.0% (the material is hygroscopic to a degree).
Microbial Limits: Total aerobic microbial count (TAMC) ≤ 1000 CFU/g, absence of S. aureus, P. aeruginosa, and Candida albicans.

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1. Pharmaceutical raw materials.
2. It can be applied in food and beverage for health care.

3. It can be applied in anti-aging product for skin care.

4. It can be applied in feed additives.

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Certificates

Basic Info

Product Name:

Silybum marianum extract

Other Name:

Silybum marianum extract;Silybum marianum,ext.;Milk thistle extract;Flavopherol;Silybum marianum extracts;Milk thistle extracts

CAS No.:

84604-20-6

InChIKeys:

SEBFKMXJBCUCAI-VGHNRKBZSA-N

Molecular Weight:

482.43618

Exact Mass:

482.121307

EC Number:

283-298-7

HScode:

2932996560

Categories:

Nutrition Supplements

Characteristics

PSA:

155

XLogP3:

1.94 (est)

Density:

1.5±0.1 g/cm3

Boiling Point:

793.0±60.0 °C at 760 mmHg

Flash Point:

274.5±26.4 °C

Refractive Index:

1.684

Water Solubility:

In water, 77.36 mg/L at 25 deg C (est)

Storage Conditions:

Store protected from light.

Vapor Pressure:

4.1X10-21 mm Hg at 25 deg C (est)

See More Silybum marianum extract Properties 

Hazard Identification

Classification of the substance or mixture

Skin sensitization, Category 1

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 3

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H317 May cause an allergic skin reaction H412 Harmful to aquatic life with long lasting effects
Prevention	P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P272 Contaminated work clothing should not be allowed out of the workplace. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P273 Avoid release to the environment.
Response	P302+P352 IF ON SKIN: Wash with plenty of water/... P333+P317 If skin irritation or rash occurs: Get medical help. P321 Specific treatment (see ... on this label). P362+P364 Take off contaminated clothing and wash it before reuse.
Storage	none
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Silybum marianum extract Safety Data Sheet 

Seller Information

Business Type:
Distributor

Main Products:
Nutrition supplement material,Pharmaceutical raw material,Chemical raw material

Location:
Changqing 5th Road, Jianghan District

Payment Terms:
TT against copy of documents

Average lead Time:
5 days

Total Annual Revenue:
$1 million-$2.5 million

Total Employees:
5-10

Year of Establishment:
2020

Wuhan Oner Biotech Co.,Ltd. located in the popular city of Wuhan, specilize in producing and developing pharmaceutical & its intermediates, Cosmetics Raw Material and Intermediate, food additive, Plant extracts,and in distributing the products of our own company. We serves our clients by supplying high-quality.These products are manufactured in ISO 9001 certified plants and have continuously been passing quality inspection by CIQ (China Entry & Exit Inspection and Quarantine Bureau),100% pass rate. Our company has professional staff who deal with chemical R&D and scientific management, and holds several sets of analyzing instruments with high efficiency and high sensitivity, such as HPLC, GC and Spectrophotometer. We have professional sales team, focus on quality and service, and we have achieved excellent performance over the years. Our company is committed to the development of international market , the products are mainly exported to many countries and regions, such as Europe, America, South-east Asia, the Middle East and Africa etc. With constant efforts and good service, We sincerely hope to establish long-term cooperation and common development with our customers.

Inquiry History

4 Inquiries

Country	Product	Purchase Quantity	Date Posted
Poland	API MilkThistleExtract EXTRACTED WITH ETHYL ACETATE ONLY API	500 KG	Mar 19, 2026
India	Milk Thistle-Sylimarin 80%	200 KG	Jun 21, 2025
Portugal	Cardo Mariano	300 KG	Mar 6, 2025
Portugal	Silybum marianum	100 KG	Mar 6, 2025

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Liver Health Natural Silymarin Silybin Isosilybin Milk Thistle Extract

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