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Home > Pharmaceutical Intermediates > Bulk Drug Intermediates > PARECOXIB NA for Sale > Parecoxib Sodium CAS 197502-82-2 99% Purity COX-2 Inhibitor API Intermediate for Anti-inflammatory fk
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Parecoxib Sodium CAS 197502-82-2 99% Purity COX-2 Inhibitor API Intermediate for Anti-inflammatory fk

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Unit Price:

$100-130/G FOB

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CAS No.:

197502-82-2

Grade:

Reagent Grade

Content:

99%

Port:

qingdao

Brand:

//

Packaging:

10mg, 25mg, 50mg, 100mg, 1g

Sample Available:

Yes

Price valid (until):

2026-10-25

Company Type:
Trader
Location:
China
Payment Terms:
TT against copy of documents,TT against B/L draft before shipment,100% TT in advance
Average Lead Time:
7 days
Qualification:
Main Products:

Medetomidine,Medetomidine hydrochloride,D-Lysergic Acid Methyl Ester,SR17018,Fluralaner,GS-441524

  • Product Description

  • Seller Information

  • Description

    —— Product Specification ——

    Parameter Specification Details
    Product Name Parecoxib Sodium Sodium N-[[4-(5-methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]propanamide
    CAS Number 197502-82-2 —
    Molecular Formula C₁₉H₁₇N₂NaO₄S 19 carbons, 17 hydrogens, 2 nitrogens, 1 sodium, 4 oxygens, 1 sulfur
    Molecular Weight 392.41 g/mol —
    Appearance White to off-white powder Visual inspection
    Purity ≥99.0% Determined by HPLC
    Water Content ≤3.0% Karl Fischer
    Storage Store at 4°C, sealed, protected from light Refrigerator
    Packaging 1g, 5g, 10g, 25g, 100g Amber glass vials/bottles
    Application Research use only COX-2 inhibitor studies


    —— Product Detail ——

    Product Overview

    Parecoxib sodium (CAS 197502-82-2) is a water-soluble amide prodrug of valdecoxib, designed as an injectable selective cyclooxygenase-2 (COX-2) inhibitor . It has the molecular formula C₁₉H₁₇N₂NaO₄S and a molecular weight of 392.41 g/mol . Unlike other COX-2 inhibitors that suffer from poor water solubility, parecoxib sodium can be administered by either intramuscular (i.m.) or intravenous (i.v.) routes, making it suitable for managing acute pain in clinical settings . The compound is marketed under the brand name Dynastat .



    Packaging & Shipping

      • Research quantities: 10mg, 25mg, 50mg amber glass vials

      • Bulk quantities: 100mg, 1g, 5g amber glass bottles

      • Custom packaging available upon request

      • Not classified as hazardous material for transport under normal conditions

      • Product for research and analytical use only; not for human or veterinary use

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    — Company profile ——


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    Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.

    Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.

    We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.

    To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.

    Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers.

     

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    —— Q&A ——

    Q1: How to confirm the product quality before placing orders?
    A: By sending you available samples. Or if you have special requirements for the goods, we can prepare samples according to your requirements for confirmation.

    Q2: Can you supply free samples?
    A: Yes, we can provide a free sample, but the shipping cost will be paid by the customers. You can either pay the shipping cost or arrange a courier to collect the samples.

    Q3: How do you treat quality complaints?
    A: All our products are strictly tested by our QC and confirmed by QA; unqualified material will not be released to customers. If any quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately.

    Q4: What is your MOQ? Is there a discount?
    A: For highvalue products, our MOQ starts from 1g and generally starts from 10g. For other lowprice products, our MOQ starts from 100g and 1kg.
    Q: Is there a discount?
    A: Yes, for larger quantities, we always support with better prices.

    Q5: How to start orders or make payments?
    A: You can send us your Purchase Order (if your company has one), or just send a simple confirmation by email or via Trade Manager. We will then send you a Proforma Invoice with our bank details for your confirmation, and you can make payment accordingly. If you have other preferred payment methods, we are open to discussion and negotiation.



    ECHEMI Editorial Reference
    Parecoxib sodium is an injectable COX-2 inhibitor, launched as an anti-inflammatory agent and for the management of acute pain. Parecoxib is an amide prodrug of Pharmacia’s valdecoxib. It can be administered by either i.m. or i.v. routes, in contrast to other currently available COX-2 inhibitors which are poorly watersoluble. Parecoxib sodium can be prepared from valdecoxib by acylation of the sulfonamide with propionic anhydride. Parecoxib sodium exhibited potent acute and chronic antiinflammatory activity in rats, as demonstrated in the carrageenan air pouch model, where 98% of inhibition was achieved with the dose of 0.3mg/kg, and in the adjuvant arthritis model (ED50= 0.08mglkg). Moreover, in the carrageenan footpad edema model, parecoxib sodium showed excellent efficacy (ED50= Smglkg) and a rapid onset of action comparable with the most potent analgesic ketorolac. In this model, it produced a complete blockade of the carrageenan-induced hyperalgesia within 1 h after iv. administration. Pharmacokinetic studies indicated that parecoxib sodium completely and rapidly converted in valdecoxib with bioequivalence found between parenterally administered parecoxib sodium and orally administered valdecoxib. The maximum plasma concentrations of valdecoxib were 2530% greater after iv. than i.m. administration of parecoxib and tnax was respectively 0.5 h after iv. and 1.5 h after i.m. administration. Parecoxib sodium had greater gastrointestinal tolerance than ketorolac and had no significant effect on platelet aggregation. Parecoxib sodium was as effective as ketorolac or even superior to morphine and placebo in the treatment of severe pain (such as that observed following gynaecologic or orthopaedic surgery). Mean times to rescue medication were longer with parecoxib compared to morphine. Parecoxib sodium works 12-14 min after i.v. administration and a dose of 40 mg provides good or excellent relief of pain in approximately 90% of patients. Thus, parecoxib sodium is a non-narcotic, specific COX-2 inhibitor, which provides potent analgesic ability and fulfils some important requirements for the pain management in the post-operative period such as i.v. formulation, rapidity of action, and short half-life. Furthermore, although valdecoxib is a substrate for CYP3A4 as other drugs used in the perioperative period, it does not interfere either with the metabolism of the sedative/tranquilizer, midazolam, or with the intravenous anesthetic propofol.
    Research & Reference Note

    Parecoxib Sodium CAS 197502-82-2 99% Purity COX-2 Inhibitor API Intermediate for Anti-inflammatory fk is listed on ECHEMI for industrial / laboratory sourcing. This listing is for industrial and laboratory research use. Product information on ECHEMI is provided for sourcing and specification reference. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.

    Disclaimer: This listing is for industrial and laboratory research use. Product information on ECHEMI is provided for sourcing and specification reference. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.

    Reviewed by ECHEMI Scientific Review - Platform editorial review for research chemicals

    Certificates
    • Parecoxib Sodium CAS 197502-82-2 99% Purity COX-2 Inhibitor API Intermediate for Anti-inflammatory fk Certificates 1 TDS

    Basic Info
    Product Name:

    PARECOXIB NA

    Other Name:

    PARECOXIB NA

    CAS No.:

    197502-82-2

    Molecular Formula:

    C19H17N2NaO4S

    InChIKeys:

    InChIKey=IMBMHWVEMVJSIQ-UHFFFAOYSA-N

    Molecular Weight:

    392.4

  • Seller Information
    Business Type:

    Trader

    Main Products:

    Medetomidine,Medetomidine hydrochloride,D-Lysergic Acid Methyl Ester,SR17018,Fluralaner,GS-441524

    Location:

    RONGSHENG BEIYUANDAJIE 9, LICHENG DISTRICT,JINAN, SHANDONG CHINA

    Payment Terms:

    TT against copy of documents,TT against B/L draft before shipment,100% TT in advance

    Average lead Time:

    7 days

    Total Annual Revenue:

    $1 million-$2.5 million

    Total Employees:

    11-50

    Year of Establishment:

    2022

    Jinan Topfull Chemical Co., Ltd. is a global chemical Industrial and focuses on advanced chemical technology. Specialized in Cosmetic materials, water treatment, fine chemicals and so on. We are looking forward to working together with the people of all circles at home and abroad to seek common development!
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