CAS 86404-04-8 Factory Supply Best Price 3-O-Ethyl-L-Ascorbic Acid White Powder HHD 99% purity

1. Description
3-O-Ethyl-L-ascorbic acid (vitamin C ethyl ether) is an ethylated derivative of vitamin C at the C3 position. Its molecular structure has been optimized through ethoxy modification, enabling it to maintain its integrity and transdermal absorption capacity under non-acidic pH conditions. As an enzyme-activated precursor, it releases active ascorbic acid in the deep layers of the epidermis through hydrolysis by esterases, achieving precise release and synergistic photoprotection. Its C3-position ethoxy modification optimizes transdermal accumulation and formulation compatibility at the polar oil-water interface. As a dual-pathway antioxidant, it simultaneously activates collagen synthesis and inhibits elastase activity in fibroblasts, protecting elastic fibers from both structural maintenance and degradation inhibition perspectives. Its ability to maintain molecular integrity under non-acidic pH conditions makes it suitable for sensitive skin and peptide-based formulations. Through mitochondrial-targeted delivery, Vitamin C ethyl ether reduces cytochrome c release and apoptosis signaling during UV exposure, thereby enhancing cellular protection. It is widely used in anti-aging serums, brightening creams, and functional skincare products.
2. Application
(1) Skincare and Cosmetic Development: As a stable vitamin C derivative, it is incorporated into brightening creams, anti-aging serums, spot-fading products, and sun-damage repair skincare products to brighten the complexion and address photoaging concerns.
(2) Functional Ingredient Research: It serves as an active ingredient in formulation and process studies for brightening and spot-fading products, where its effects on tyrosinase activity and melanin synthesis are evaluated.
(3) Drug Delivery System Research: Incorporated into delivery carriers such as enteric-coated capsules or lipid gels to study its role in promoting transdermal penetration of active ingredients and its sustained-release properties.
(4) Skin Permeation Research: Used in in vitro skin permeation models to evaluate the impact of different solvent systems on the transdermal absorption of active ingredients and to study their transdermal delivery characteristics.
(5) Oral Medicine Research: Used in the development of enamel surface treatment agents to investigate its application in restoring bond strength of teeth after bleaching during orthodontic treatment.
3. Main Efficacy
(1) Antioxidant and DNA Protection: Scavenges reactive oxygen species (ROS) induced by UV radiation, thereby reducing oxidative stress-induced damage to skin cells. In vitro studies have shown that it significantly reduces levels of the UVB-induced DNA damage marker, the histone γ-H2AX, protecting cellular DNA from photodamage.
(2) Inhibition of Melanin Synthesis: By inhibiting tyrosinase activity, it blocks the melanin biosynthetic pathway. In a three-dimensional recombinant pigmented epidermal model, treatment significantly reduces melanin content, thereby lightening dark spots and brightening skin tone.
(3) Promotion of collagen synthesis: Acting as a cofactor for prolyl hydroxylase and lysyl hydroxylase, it participates in the regulation of collagen synthesis upon entering the dermis. In fibroblast models, it promotes collagen production, improving skin elasticity and firmness.
(4) Advantages in Skin Penetration and Stability: Ethyl modification confers amphiphilic properties to the molecule, enabling it to penetrate the skin’s stratum corneum and reach the epidermis and dermis more easily than native vitamin C. It also exhibits excellent photostability, thermal stability, and air stability, making it resistant to oxidation and discoloration in formulations.
(5) Anti-inflammatory and Skin Protection: It possesses antibacterial and anti-inflammatory properties, helping to alleviate skin inflammatory reactions caused by UV exposure and protect the skin barrier function.