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Magnolol528-43-8

Name: Magnolol528-43-8
Brand: OORENT
SKU: pr2610091753
Price: 33 USD
Availability: InStock

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$33-34/MT FOB

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CAS No.:

528-43-8

Grade:

Pharmaceutical Grade

Content:

99.5%

Port:

shanghai

Brand:

OORENT

Packaging:

Vial/Bottle/Bag/Carton

Sample Available:

Yes

Price valid (until):

2026-11-09

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

Payment Terms:

100% TT in advance

Average Lead Time:

10 days

Qualification:

Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
Seller Information
Inquiry History

Description

Product Detailv

Magnolol Basic information

Description References

Product Name:	Magnolol
Synonyms:	5,5'-DIALLYL-BIPHENYL-2,2'-DIOL;5,5'-DIALLYL-2,2'-BIPHENYLDIOL;5,5'-DIALLYL-2,2'-DIHYDROXYBIPHENYL;HONOKIOL(P);MAGNOLOL(SH);5',5-di-2-propenyl-(1,1'-Biphenyl)-2,2'-diol;MAGNOLOL;Magnolia officinalis Rehd.et Wils
CAS:	528-43-8
MF:	C18H18O2
MW:	266.33
EINECS:	610-903-7
Product Categories:	Herb extract;Plant extract;Nutritional Ingredients;chemical reagent;pharmaceutical intermediate;phytochemical;Aromatic Phenols;The group of Magnolia;Antifungal;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;natural product;Inhibitors;Honokiol
Mol File:	528-43-8.mol

Magnolol Chemical Properties

Melting point	101.5-102°
Boiling point	180°C/1mmHg(lit.)
density	1.107±0.06 g/cm3(Predicted)
FEMA	4559 \| MAGNOLOL
storage temp.	Sealed in dry,2-8°C
solubility	ethanol: soluble1mg/mL
pka	9.49±0.43(Predicted)
form	Solid
color	White to Almost white
Odor	bitter
biological source	plant
λmax	292nm(EtOH)(lit.)
Merck	14,5697
JECFA Number	2023
Stability:	Light Sensitive
Major Application	metabolomics vitamins, nutraceuticals, and natural products
Cosmetics Ingredients Functions	ANTIOXIDANT BLEACHING
InChI	1S/C18H18O2/c1-3-5-13-7-9-17(19)15(11-13)16-12-14(6-4-2)8-10-18(16)20/h3-4,7-12,19-20H,1-2,5-6H2
InChIKey	VVOAZFWZEDHOOU-UHFFFAOYSA-N
SMILES	Oc1ccc(CC=C)cc1-c2cc(CC=C)ccc2O
LogP	4.502 (est)
CAS DataBase Reference	528-43-8(CAS DataBase Reference)

Safety Information

Hazard Codes	N
Risk Statements	37/38-41-51/53
Safety Statements	26-39-61
RIDADR	UN 3077
WGK Germany	3
RTECS	DV5105500
HazardClass	9
HS Code	29072990
Storage Class	11 - Combustible Solids
Hazard Classifications	Aquatic Chronic 2 Eye Dam. 1 Skin Irrit. 2 STOT SE 3
Hazardous Substances Data	528-43-8(Hazardous Substances Data)
Toxicity	LD50 orl-mus: 2200 mg/kg BRXXAA #5135746

MSDS Information

Provider	Language
Magnolol	English

Magnolol Usage And Synthesis

Description	Magnolol is an organic compound belonging to lignan. It is a kind of bioactive compounds identified from the bark of the Magnolia officinalis or M. grandiflora. It has been supplemented to Asian traditional medicine for the treatment of anxiety, sleep disorders, and allergic disease. It can act on the GABA receptor in vitro as a strong allosteric modulator. It also has antifungal effect, anti- periodontal activity as well as many osteoblast-stimulating and osteoclast-inhibiting activities. It has also found that magnolol can also activate the cannabinoid (CB) receptors.
References	https://en.wikipedia.org/wiki/Magnolol https://www.caymanchem.com/product/14233
Description	Magnolol is a bioactive compound isolated from the bark of M. officinalis that has been used in Asian traditional medicine for the treatment of anxiety, sleep disorders, and allergic diseases. Magnolol can activate cannabinoid (CB) receptors, behaving as a partial agonist with selectivity for the peripheral CB₂ subtype (EC₅₀ = 3.28 μM; K_i = 1.44 μM) versus central CB₁ (EC₅₀ = 18.3 μM; K_i = 3.15 μM).
Chemical Properties	White or off-white powder
Uses	Magnolol is the bioactive phytochemicals found in Magnolia officinalis (1). Magnolol has been used to treat anxiety, cough, headache and allergies (2). It also inhibits tumor necrosis factor-a-*induced ICAM-1 expression in human lung epithelial cells.
Definition	ChEBI: Magnolol is a member of biphenyls.
Hazard	Moderately toxic by ingestion.
Biological Activity	Magnolol, a natural lignan isolated from the stem bark of Magnolia officinalis, is a dual agonist of both RXRα and PPARγ, with EC50 values of 10.4 μM and 17.7 μM, respectively.
Mechanism of action	Magnolol (5,5’-diallyl-2,2’-dihydroxybiphenyl) is a polyphenolic binaphthalene compound and a structural isomer of honokiol. Both magnolol and honokiol are isolated from the stem bark of a traditional Chinese herbal medicine Magnolia officinalis, which has been used for management of nervous disturbance, abdominal distention or disorders, gastrointestinal food stagnancy, and coughing and dyspnea. Magnolol has showed a wide spectrum of beneficial activities, including anti-inflammation, antimicroorganism, antioxidation, antiangiogenesis, anticancer, neuroprotection, cardiovascular protection, and lipolysis activities.
Safety Profile	Moderately toxic by ingestion.When heated to decomposition it emits acrid smoke andirritating vapors.
in vitro	Magnolol is a bioactive lignin found in the bark of the Houpu magnolia (Magnolia officinalis) which shows antifungal properties. Magnolol preferentially increases (3)H-muscimol binding to hippocampus compared to cortex and cerebellum in vitro. Magnolol has a more potent enhancing effect on GABAA receptor alpha2 subunit. Magnolol shows significant inhibitory activities against Trichophyton mentagrophytes, Microsporium gypseum, Epidermophyton floccosum, Aspergillus niger, Cryptococcus neoformans, and Candida albicans with minimum inhibitory concentrations (MIC) in a range of 25-100 μg/ml.
in vivo	Magnolol (5-15 mg/kg, p.o.) significantly attenuates the phenotypic severity of dextran sulfate sodium (DSS)-induced colitis in mice. Magnolol (10, 15 mg/kg, p.o.) attenuates histopathological changes and myeloperoxidase activity in the colon of DSS-treated mice, decreases DSS-induced high levels of proinflammatory cytokines TNF-α, IL-1β and IL-6 in the colonic tissues. Magnolol (10 mg/kg, p.o.) also reverses abnormality of serum metabolome, and regulates tryptophan metabolic pathway in mice.
References	[1] VIKTOR REMPEL. Magnolia Extract, Magnolol, and Metabolites: Activation of Cannabinoid CB2 Receptors and Blockade of the Related GPR55[J]. ACS Medicinal Chemistry Letters, 2012, 4 1: 41-45. DOI: 10.1021/ml300235q

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ECHEMI Editorial Reference

Magnolol, a natural lignan isolated from the stem bark of Magnolia officinalis, is a dual agonist of both RXRα and PPARγ, with EC50 values of 10.4 µM and 17.7 µM, respectively.
White powder; Bitter aroma
Magnolol is a member of biphenyls.

Basic Info

Product Name:

Magnolol

Other Name:

[1,1′-Biphenyl]-2,2′-diol,5,5′-di-2-propen-1-yl-;2,2′-Bichavicol;2,2′-Biphenyldiol,5,5′-diallyl-;[1,1′-Biphenyl]-2,2′-diol,5,5′-di-2-propenyl-;5,5′-Di-2-propen-1-yl[1,1′-biphenyl]-2,2′-diol;Magnolol;5,5′-Diallyl-2,2′-biphenyldiol;NSC 293099;2-(2-Hydroxy-5-prop-2-enylphenyl)-4-prop-2-enylphenol

CAS No.:

528-43-8

Molecular Formula:

C18H18O2

InChIKeys:

InChIKey=VVOAZFWZEDHOOU-UHFFFAOYSA-N

Molecular Weight:

266.34

Exact Mass:

266.33

UNII:

001E35HGVF

NSC Number:

293099

DSSTox ID:

DTXSID0044076

HScode:

2907299090

Categories:

Biosynthetic Natural Products

Characteristics

PSA:

40.5

XLogP3:

Appearance:

White powder; Bitter aroma

Density:

1.1±0.1 g/cm3

Melting Point:

103 °C

Boiling Point:

178-180 °C @ Press: 1 Torr

Flash Point:

184.5±21.9 °C

Refractive Index:

1.602

Water Solubility:

In water, 1.24 mg/L at 25 deg C (est)

Storage Conditions:

2-8°C

Vapor Pressure:

4.37X10-7 mm Hg at 25 deg C (est)

Toxicity:

LD50 orl-mus: 2200 mg/kg BRXXAA #5135746

Henrys Law Constant:

Henry's Law constant = 9.41X10-12 atm-cu m/mol at 25 °C (est)

Experimental Properties:

Hydroxyl radical reaction rate constant = 1.12X10-10 cu cm/molec-sec at 25 °C (est)|Ozone radical reaction rate constant = 2.4X10-17 cu cm/molec-sec at 25 °C (est)

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Hazard Identification

Classification of the substance or mixture

Skin irritation, Category 2

Serious eye damage, Category 1

Specific target organ toxicity â single exposure, Category 3

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H315 Causes skin irritation H318 Causes serious eye damage H335 May cause respiratory irritation H411 Toxic to aquatic life with long lasting effects
Prevention	P264 Wash ... thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area. P273 Avoid release to the environment.
Response	P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P354+P338 IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P317 Get medical help. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P319 Get medical help if you feel unwell. P391 Collect spillage.
Storage	P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Magnolol Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10 days

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

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We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
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Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

2 Inquiries

Country	Product	Purchase Quantity	Date Posted
United Kingdom	Magnolol	200 G	Oct 9, 2026
Mexico	magnolol 98% white powder magnolol Staherb	100 KG	Nov 14, 2023

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Magnolol528-43-8

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