Product
Supplier
Encyclopedia
Inquiry
Home > Chemical Reagents > Organic Reagents > tert-Butyldimethylsilyl chloride for Sale > tert-Butyldimethylsilyl chloride High Purity Silylating Agent CAS 18162-48-6 Research Grade Reagent for Organic Synthesis
tert-Butyldimethylsilyl chloride High Purity Silylating Agent CAS 18162-48-6 Research Grade Reagent for Organic Synthesis buy - large image1
tert-Butyldimethylsilyl chloride High Purity Silylating Agent CAS 18162-48-6 Research Grade Reagent for Organic Synthesis buy - image1
tert-Butyldimethylsilyl chloride High Purity Silylating Agent CAS 18162-48-6 Research Grade Reagent for Organic Synthesis buy - image2
tert-Butyldimethylsilyl chloride High Purity Silylating Agent CAS 18162-48-6 Research Grade Reagent for Organic Synthesis buy - image3
tert-Butyldimethylsilyl chloride High Purity Silylating Agent CAS 18162-48-6 Research Grade Reagent for Organic Synthesis buy - image4
tert-Butyldimethylsilyl chloride High Purity Silylating Agent CAS 18162-48-6 Research Grade Reagent for Organic Synthesis buy - image5
tert-Butyldimethylsilyl chloride High Purity Silylating Agent CAS 18162-48-6 Research Grade Reagent for Organic Synthesis buy - image6

tert-Butyldimethylsilyl chloride High Purity Silylating Agent CAS 18162-48-6 Research Grade Reagent for Organic Synthesis

TDS 12 Inquiries

Unit Price:

$40-45/KG FOB

Get Latest Price
CAS No.:

18162-48-6

Grade:

Reagent Grade

Content:

99%

Port:

qingdao

Brand:

//

Packaging:

1g/vial, 5g/vial, 25g/vial, 100g/vial

Sample Available:

Yes

Price valid (until):

2026-11-13

Company Type:
Trader
Location:
China
Payment Terms:
TT against copy of documents,TT against B/L draft before shipment,100% TT in advance
Average Lead Time:
7 days
Qualification:
Main Products:

Medetomidine,Medetomidine hydrochloride,D-Lysergic Acid Methyl Ester,SR17018,Fluralaner,GS-441524

  • Product Description

  • Seller Information

  • Inquiry History

  • Description

    —— Product Specifications ——

    Shop tert-Butyldimethylsilyl chloride High Purity Silylating Agent CAS 18162-48-6 Research Grade Reagent for Organic Synthesis-Detailed Image 1

    —— Product Detail ——




                  • Product Overview

                    tert-Butyldimethylsilyl chloride (TBSCl) is an organosilicon compound with the molecular formula C₆H₁₅ClSi and molecular weight of 150.72 g/mol. This white to off-white crystalline solid is a widely used silylating agent in organic synthesis. The compound is valued for its ability to protect hydroxyl groups as tert-butyldimethylsilyl (TBS) ethers.

                    Synthetic Process

                    • Synthesis: TBSCl is prepared by the reaction of tert-butyldimethylsilane with chlorine or by the Grignard reaction of tert-butylmagnesium chloride with dimethyldichlorosilane

                    • Purification: The crude product is purified by fractional distillation

                    • Quality Control: The final product is analyzed to ensure ≥98.0% purity by GC

                    Mechanism of Action

                    • Silylation: Reacts with alcohols to form TBS ethers, protecting hydroxyl groups during synthetic transformations

                    • Protecting Group: The TBS group is stable under a wide range of reaction conditions and can be removed selectively using fluoride ions or acid

                    • Steric Protection: The bulky tert-butyl group provides steric hindrance that influences reaction selectivity

                    Research Applications & Market Significance

                    • Organic Synthesis: Key reagent for the protection of alcohols and phenols

                    • Pharmaceutical Research: Building block for drug discovery programs

                    • Natural Product Synthesis: Essential reagent in multistep syntheses

                    • Material Science: Used in the preparation of functionalized siloxanes and polymers

                    Quality Specifications

                    • Purity: ≥98.0% determined by GC

                    • Melting point: 86-89°C

                    • Boiling point: 125-127°C

                    • Loss on drying: ≤0.5%

                    • Storage: 2-8°C, sealed, protected from moisture

                    • Stable for 24 months when properly stored

                    Packaging & Shipping

                    • Research quantities: 25g, 100g amber glass bottles

                    • Bulk quantities: 500g, 1kg amber glass bottles

                    • Shipped at ambient temperature under inert atmosphere



    — C ompany Profile ——


     ,

    Shop Amberlite IR-120 Cation Exchange Resin Sodium Form CAS 9002-23-7 High Purity Strong Acid Cation Exchange Resin for Water Softening, Demineralization,-Detailed Image 2

    Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.

    Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.

    We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.

    To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.

    Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers.

     

    Shop Amberlite IR-120 Cation Exchange Resin Sodium Form CAS 9002-23-7 High Purity Strong Acid Cation Exchange Resin for Water Softening, Demineralization,-Detailed Image 3

    Shop Amberlite IR-120 Cation Exchange Resin Sodium Form CAS 9002-23-7 High Purity Strong Acid Cation Exchange Resin for Water Softening, Demineralization,-Detailed Image 4 

    —— Q&A ——

    Q1: How to confirm the product quality before placing orders?
    A: By sending you available samples. Or if you have special requirements for the goods, we can prepare samples according to your requirements for confirmation.

    Q2: Can you supply free samples?
    A: Yes, we can provide a free sample, but the shipping cost will be paid by the customers. You can either pay the shipping cost or arrange a courier to collect the samples.

    Q3: How do you treat quality complaints?
    A: All our products are strictly tested by our QC and confirmed by QA; unqualified material will not be released to customers. If any quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately.

    Q4: What is your MOQ? Is there a discount?
    A: For highvalue products, our MOQ starts from 1g and generally starts from 10g. For other lowprice products, our MOQ starts from 100g and 1kg.
    Q: Is there a discount?
    A: Yes, for larger quantities, we always support with better prices.

    Q5: How to start orders or make payments?
    A: You can send us your Purchase Order (if your company has one), or just send a simple confirmation by email or via Trade Manager. We will then send you a Proforma Invoice with our bank details for your confirmation, and you can make payment accordingly. If you have other preferred payment methods, we are open to discussion and negotiation.



    ECHEMI Editorial Reference
    Tert-butyldimethylsilyl chloride is a silyl chloride consisting of a central silicon atom covalently bound to one chloro, one tert-butyl and two methyl groups. tert-Butyldimethylsilyl chloride is a derivatisation agent used in gas chromatography/mass spectrometry applications. It has a role as a chromatographic reagent.

    Certificates
    • tert-Butyldimethylsilyl chloride High Purity Silylating Agent CAS 18162-48-6 Research Grade Reagent for Organic Synthesis Certificates 1 TDS

    Basic Info
    Product Name:

    tert-Butyldimethylsilyl chloride

    Other Name:

    Silane,chloro(1,1-dimethylethyl)dimethyl-;Silane,chloro-tert-butyldimethyl-;Chloro(1,1-dimethylethyl)dimethylsilane;Dimethyl-tert-butylchlorosilane;(1,1-Dimethylethyl)dimethylsilyl chloride;tert-Butyldimethylsilyl chloride;tert-Butyldimethylchlorosilane;Chlorodimethyl-tert-butylsilane;Chloro-tert-butyldimethylsilane;Dimethyl(1,1-dimethylethyl)chlorosilane;Dimethyl-tert-butylsilyl chloride;TBDMS chloride;tert-Butylchlorodimethylsilane;t-Butyldimethylchlorosilane;TBDMS-Cl;tert-Butyl(dimethyl)silane chloride;2-(Chlorodimethylsilyl)-2-methylpropane;TBSCl;LS 1190;2-[4-(TertButyldimethylsilanyloxy)phenyl] chloride;132560-73-7;187979-91-5

    CAS No.:

    18162-48-6

    Molecular Formula:

    C6H15ClSi

    InChIKeys:

    InChIKey=BCNZYOJHNLTNEZ-UHFFFAOYSA-N

    Molecular Weight:

    150.72

    Exact Mass:

    150.72

    BRN:

    505999

    EC Number:

    242-042-4

    UNII:

    550OPF5Z9F

    DSSTox ID:

    DTXSID4038843

    HScode:

    29310095

    Categories:

    Organic Reagents

    Characteristics
    PSA:

    0

    XLogP3:

    3.40

    Appearance:

    Clear colorless Liquid

    Density:

    0.872 g/cm3

    Melting Point:

    86-88 °C (sublm)

    Boiling Point:

    126 °C

    Flash Point:

    73 °F

    Refractive Index:

    1.411

    Water Solubility:

    soluble in chloroform and ethyl acetate. Insoluble in water.

    Storage Conditions:

    Store at 5°C

    Vapor Pressure:

    12.089mmHg at 25°C

    Hazard Identification

    Classification of the substance or mixture

    Flammable solids, Category 2

    Skin corrosion, Sub-category 1A

    Serious eye damage, Category 1

    Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2

    GHS label elements, including precautionary statements

    Pictogram(s)
    Signal word

    Danger

    Hazard statement(s)

    H228 Flammable solid

    H314 Causes severe skin burns and eye damage

    H411 Toxic to aquatic life with long lasting effects

    Precautionary statement(s)
    Prevention

    P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.

    P240 Ground and bond container and receiving equipment.

    P241 Use explosion-proof [electrical/ventilating/lighting/...] equipment.

    P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

    P260 Do not breathe dust/fume/gas/mist/vapours/spray.

    P264 Wash ... thoroughly after handling.

    P273 Avoid release to the environment.

    Response

    P370+P378 In case of fire: Use ... to extinguish.

    P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

    P363 Wash contaminated clothing before reuse.

    P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

    P316 Get emergency medical help immediately.

    P321 Specific treatment (see ... on this label).

    P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

    P305+P354+P338 IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

    P317 Get medical help.

    P391 Collect spillage.

    Storage

    P405 Store locked up.

    Disposal

    P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

    Other hazards which do not result in classification

    no data available

    Handling and Storage

    Precautions for safe handling

    Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

    Conditions for safe storage, including any incompatibilities

    Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

  • Seller Information
    Business Type:

    Trader

    Main Products:

    Medetomidine,Medetomidine hydrochloride,D-Lysergic Acid Methyl Ester,SR17018,Fluralaner,GS-441524

    Location:

    RONGSHENG BEIYUANDAJIE 9, LICHENG DISTRICT,JINAN, SHANDONG CHINA

    Payment Terms:

    TT against copy of documents,TT against B/L draft before shipment,100% TT in advance

    Average lead Time:

    7 days

    Total Annual Revenue:

    $1 million-$2.5 million

    Total Employees:

    11-50

    Year of Establishment:

    2022

    Jinan Topfull Chemical Co., Ltd. is a global chemical Industrial and focuses on advanced chemical technology. Specialized in Cosmetic materials, water treatment, fine chemicals and so on. We are looking forward to working together with the people of all circles at home and abroad to seek common development!
  • Inquiry History
    12 Inquiries
    Country Product Purchase Quantity Date Posted
    India

    tert-Butyldimethylsilyl chloride

    30 KG Jun 5, 2025
    India

    tert-Butyldimethylsilyl Chloride

    100.00 KG Sep 13, 2024
    Czech

    tert-Butyldimethylchlorosilane

    200 KG Nov 6, 2024
    India

    Ethyl bromodifluoroacetate

    100.00 KG Sep 13, 2024
    India

    1,2 Dibromobenzene

    100.00 KG Sep 13, 2024
    India

    2,3,3-Trifluoro-2-propen-1-ol

    100.00 KG Sep 13, 2024
    India

    2-Bromo Aniline

    100.00 KG Sep 13, 2024
    India

    3-Bromo-1,1,2-Trifluoroprop-1-Ene

    100.00 KG Sep 13, 2024
    India

    2-Bromoethanol

    100.00 KG Sep 13, 2024
    India

    2-bromo-2,2-difluoroethane-1-ol

    100.00 KG Sep 13, 2024
    India

    1-Adamantanecarboxylic acid

    100.00 KG Sep 13, 2024
    India

    2-Bromobenzonitrile

    100.00 KG Sep 13, 2024
    Post an enquiry for this product
pic ×

Scan the QR Code to Share

All products displayed on this website are only for non-medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.

According to relevant laws and regulations and the regulations of this website, units or individuals who purchase hazardous materials should obtain valid qualifications and qualification conditions.

The information shown above is provided by the enterprise itself, and the authenticity, accuracy and legitimacy of the content are the responsibility of the publishing company. ECHEMI does not bear any guarantee responsibility for this. Please be aware that risks in internet transactions objectively exist.

Feedback & Suggestions
Send Message

Thank you for your feedback. If you require further assistance, please contact us by email at info@echemi.com or call us at +86-532-55729510.