tert-Butyldimethylsilyl chloride
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tert-Butyldimethylsilyl chloride
structure -
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CAS No:
18162-48-6
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Formula:
C6H15ClSi
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Chemical Name:
tert-Butyldimethylsilyl chloride
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Synonyms:
Silane,chloro(1,1-dimethylethyl)dimethyl-;Silane,chloro-tert-butyldimethyl-;Chloro(1,1-dimethylethyl)dimethylsilane;Dimethyl-tert-butylchlorosilane;(1,1-Dimethylethyl)dimethylsilyl chloride;tert-Butyldimethylsilyl chloride;tert-Butyldimethylchlorosilane;Chlorodimethyl-tert-butylsilane;Chloro-tert-butyldimethylsilane;Dimethyl(1,1-dimethylethyl)chlorosilane;Dimethyl-tert-butylsilyl chloride;TBDMS chloride;tert-Butylchlorodimethylsilane;t-Butyldimethylchlorosilane;TBDMS-Cl;tert-Butyl(dimethyl)silane chloride;2-(Chlorodimethylsilyl)-2-methylpropane;TBSCl;LS 1190;2-[4-(TertButyldimethylsilanyloxy)phenyl] chloride;132560-73-7;187979-91-5
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CAS No:
Description
Tert-butyldimethylsilyl chloride is a silyl chloride consisting of a central silicon atom covalently bound to one chloro, one tert-butyl and two methyl groups. tert-Butyldimethylsilyl chloride is a derivatisation agent used in gas chromatography/mass spectrometry applications. It has a role as a chromatographic reagent.
tert-Butyldimethylsilyl chloride Basic Attributes
150.72
150.72
505999
242-042-4
550OPF5Z9F
DTXSID4038843
29310095
Characteristics
0
3.40
Clear colorless Liquid
0.872 g/cm3
86-88 °C (sublm)
126 °C
73 °F
1.411
soluble in chloroform and ethyl acetate. Insoluble in water.
Store at 5°C
12.089mmHg at 25°C
Safety Information
III
4.1
UN 2925 4.1/PG 2
2
22-35-40-34-10-19-11-67-65-63-48/20-20/21/22-45-23/24/25-37-36/37/38
26-36/37/39-46-62-45-25-16-28-27-33-29-53-36/37
VV2000000
C,F,T,Xn
Flammable/Corrosive/Moisture Sensitive
Stable under normal temperatures and pressures.
P210-P261-P280-P301 + P310-P305 + P351 + P338-P310
H225-H304-H314-H336-H361d-H373
|Danger|H228 (78.57%): Flammable solid [Danger Flammable solids]|P210, P240, P241, P260, P261, P264, P271, P280, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P310, P312, P321, P363, P370+P378, P403+P233, P405, and P501|Aggregated GHS information provided by 266 companies from 19 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
tert-Butyldimethylsilyl chloride Use and Manufacturing
The pentane solution of dichlorodimethylsilane was cooled to 0°C, and a pentane solution of tert-butyllithium was added dropwise with stirring under nitrogen. Maintain 0°C, stir the reaction for 1.5h, then warm to 25°C, and continue the reaction for 48h. Distillate, collect the fraction at 125°C (97.5kPa), and leave to solidify to obtain tert-butyldimethylchlorosilane. The yield is 70%.
Used in pharmaceutical intermediates and organic synthesis, it is a sterically hindered silicone protective agent, widely used in the synthesis of technical materials. In the synthesis of ribonucleosides, it is used as a protective group for the hydroxyl group. It is also an oxidizing agent and decyanation agent. Silanizing agent. In organic synthesis, it is used as hydroxyl protecting agent and derivatization reagent for analysis and preparation. Protect tertiary alcohols. Reacts with alcohols to form silicon ether. Determine the conformation of cholesterol derivatives. Synthetic prostaglandins, certain antibiotics, lipid-lowering drugs, Lovastatin (Lovastatin) and Simvastatin (Simvastatin) auxiliary materials.
Silane, chloro(1,1-dimethylethyl)dimethyl-: ACTIVE
Computed Properties
Molecular Weight:150.72
Rotatable Bond Count:1
Exact Mass:150.0631547
Monoisotopic Mass:150.0631547
Heavy Atom Count:8
Complexity:81
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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tert-Butyldimethylsilyl chloride
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