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Home > Pharmaceutical Intermediates > Bulk Drug Intermediates > Retatrutide for Sale > High Purity 99% Retatrutide Peptide CAS 2381089-83-2 | Weight Loss & Metabolic Support 40mg
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High Purity 99% Retatrutide Peptide CAS 2381089-83-2 | Weight Loss & Metabolic Support 40mg

7503 Inquiries

Unit Price:

$183/UNIT FOB

Get Latest Price
CAS No.:

2381089-83-2

Grade:

Pharmaceutical Grade

Content:

99%

Port:

shenzhen

Brand:

zhongma

Packaging:

40mg*10vials

Sample Available:

Yes

Price valid (until):

2027-10-30

Company Type:
Trader
Location:
China
Payment Terms:
TT against copy of documents,100% TT in advance
Average Lead Time:
1 days
Qualification:
Main Products:

GLP-1,Retatrutide,Tirzepatide,Peptides

  • Product Details

  • Seller Information

  • Inquiry History

  • Description
     Sales manager:sunny 

     whatsapp:+86 18830992163 
     Email:sunny@hzzmtrade.cn 



      Product Detail  


    --What is Retatrutide ?

    Retatrutide is a triple glucagon, GIP, and receptor agonist. Retatrutide showed glucose control and weight loss in patients with type 2 diabetes mellitus (T2DM).Retatrutide (LY3437943) is a triple agonist peptide of the glucagon receptor (GCGR), glucosedependent polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor .

    Retatrutide can be used for the research of obesity.Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides.

    Retatrutide: The "Triple-Target" Breakthrough Technology in Weight Loss. You may have heard of Semaglutide and Tirzepatide, but the evolution of weight loss medicine never ceases. As a new-generation metabolic powerhouse, Retatrutide—distinguished by its pioneering "triple-target" mechanism—has been hailed by the scientific community as the "gold standard" in the field of weight loss [Lilly's Triple Agonist Retatrutide Demonstrated Significant].

    Retatrutide (pronounced Ret-uh-true-tide), once-weekly  medication currently being studied for the treatment of obesity and type 2 diabetes. It is a novel peptide acting as a triple hormone receptor agonist, targeting the glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon receptors. By activating all three of these receptors, Retatrutide aims to provide more potent metabolic benefits than medications that target only one or two of these pathways.

    Retatrutide is a new-generation, blockbuster "triple-target" metabolic modulator developed by Eli Lilly, hailed by the medical community as the "pinnacle" of weight management and metabolic therapy. Operating through a pioneering "triple-agonist" mechanism, it simultaneously activates three receptors—GLP-1, GIP, and Glucagon. This action not only powerfully suppresses appetite and delays gastric emptying at the source but also actively accelerates caloric expenditure and fat breakdown, achieving a revolutionary leap from merely "controlling intake" to "boosting metabolism." In the recently completed global Phase III TRIUMPH-1 clinical trial, a 12 mg dose of Retatrutide helped patients achieve an average weight reduction of 28.3% (approximately 70 pounds) over 80 weeks, with nearly half of the subjects losing more than 30% of their body weight. These stunning clinical results directly rival the efficacy of bariatric surgery and significantly surpass that of current single- or dual-target therapies available on the market. Beyond its unparalleled weight-loss performance, Retatrutide also demonstrated robust clinical benefits in reversing non-alcoholic fatty liver disease, significantly lowering blood glucose (HbA1c), and comprehensively improving various cardiovascular and metabolic markers. As a trailblazer in the future multi-billion-dollar metabolic market, Retatrutide not only redefines the standard of care for obesity but, backed by safe and groundbreaking scientific data, offers hundreds of millions of patients worldwide—who suffer from overweight conditions, Type 2 diabetes, and fatty liver disease—the ultimate non-invasive solution for scientifically and safely restoring their health without the need for surgery.


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    --Description 

    Product name Retatrutide CAS NO. 2381089-83-2
     Purity 99% Molecular weight 4731.33
    Appearance White powder Molecular Formula C221H342N46O68
    Storage Frozen Function Weight loss
    Specifications 40mg/vial MNQ 1 box of 10 vials


     Product Function 



    1.Treatment of depression and anxiety disorders: Retatrutide has been shown to have antidepressant and anxiolytic effects in preclinical studies, suggesting that it could be a promising treatment option for individuals with these conditions.

    2.Prevention of neurodegenerative diseases: Retatrutide has neuroprotective properties that may be useful in preventing or slowing the progression of neurodegenerative diseases such as Alzheimer's and Parkinson's.

    3.Enhancement of cognitive function: Retatrutide has been shown to improve learning and memory in animal studies, suggesting that it could have potential as a cognitive enhancer in humans.

    4.Treatment of chronic pain: Retatrutide has been shown to have analgesic effects in preclinical studies, suggesting that it could be a useful treatment option for individuals with chronic pain conditions.

    5.Promotion of wound healing: Retatrutide has been shown to accelerate wound healing in animal studies, suggesting that it could have potential as a therapeutic agent for promoting wound healing in humans. 



    Product Application 


    1.Retatrutide is often used in the pharmaceutical industry, weight losing, etc.
    2.Retatrutide is a kind of peptide product.
    3.Retatrutide acetate can inhibited GCGR, GIPR and GLP-1R.
    4.Retatrutide acetate is activated by glucagon receptors resulting in significant weight loss and increased energy expenditure.
    5.Retatrutide acetate can be used in studies of obesity.


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     Why choose us? 



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      Product Images  


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        Company Profile  


    Our company is a modern advanced enterprise specializing in production and exportation of APIs, Pharmaceutical intermediates, plant extracts etc. Our products are widely used in medicine, health care products, cosmetics, nutritional supplements and food additives areas. Those products of both quality and technical content have reached the domestic advanced level. Since its establishment, the company has attached great importance to the team training and technical reform. Our modern production equipment guarantees for a fast and effective production with a superior degree of accuracy throughout the whole production line, everything is done in-house, processing, extraction, packaging and transportation of all links, ensuring maximum quality and efficiency. We are constantly research and development new ingredients and innovative new products, have earned the respect & Admiration from the worldwide customers. After years of continuous development, company has been accumulated rich experience in international trade and customer resources, established a stable customer base and perfect marketing service network. In addition, the company has established long-term technical cooperation with experts and professors from many universities and research institutes in the province.

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    ECHEMI Editorial Reference
    Retatrutide is a novel triple agonist peptide of the glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR) and glucagon-like peptide-1 receptor (GLP-1R). Retatrutide inhibits human GCGR, GIPR and GLP-1R with EC50 values of 5.79, 0.0643 and 0.775 nM, respectively and mouse GCGR, GIPR, and GLP-1R with EC50 values of 2.32, 0.191 and 0.794 nM, respectively. It is an important tool for obesity research.Retatrutide potently activates the GLP-1R signaling pathway to stimulate glucose-dependent insulin secretion through activity at the GIP receptor (GIPR) or the GLP-1R.Retatrutide is a synthetic peptide with glucose-lowering effects. It is an antidiabetic agent against type 2 diabetes (T2D), stimulating insulin and suppressing glucagon secretion in a glucose-dependent manner.Retatrutide was also shown to delay gastric emptying, lower fasting and postprandial glucose concentration, decrease food intake and reduce body weight in patients with type 2 diabetes.
    Retatrutide (LY-3437943) was discovered by the American pharmaceutical company Eli Lilly and Company. It is a triple glucagon hormone receptor agonist (GLP-1, GIP, and GCGR receptors) for obesity. The 2024 Lasker~DeBakey Clinical Medical Research Award has been given to Joel Habener and Svetlana Mojsov for their discovery of a new hormone GLP-1(7-37) and to Lotte Knudsen for her role in developing sustained acting versions of this hormone as a treatment for obesity.

    Basic Info
    Product Name:

    Retatrutide

    Other Name:

    Retatrutide;GIPR/GLP-1R;LY3437943Retatrutide;Retalutide;Retatrutide (sodium salt);Retatrutide RT5;retatrutide 5mg;Retatratide

    CAS No.:

    2381089-83-2

    InChIKeys:

    MLOLQJNKXBNWFW-SAGGEDDASA-N

    Molecular Weight:

    0

    EC Number:

    200-001-8

    Color/Form:

    White lyophilized

    Characteristics
    Water Solubility:

    Soluble in water (5mg/ml).

    Storage Conditions:

    -20°C

    Critical Temperature & Pressure:

    -20°C

    Research
    Class:

    Triple agonist — GCGR, GIPR, GLP-1R

    Status:

    Investigational (Phase 3)

    Mechanism:

    Simultaneously activates glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R). Engineered from the native GIP backbone with amino acid substitutions to confer GCGR and GLP-1R activity.

    EC50 (Human GCGR):

    5.79 nM

    EC50 (Mouse GIPR):

    0.191 nM

    EC50 (Mouse GLP1R):

    0.794 nM

    EC50 (Mouse GCGR):

    2.32 nM

    EC50 (Human GLP1R):

    0.775 nM

    EC50 (Human GIPR):

    0.0643 nM

    Source:

    Jastreboff AM, et al. N Engl J Med. 2023;389(6):514-526.DOI

    Clinical Development:

    NCT04881760; NCT05882045; NCT06354660

    References
    ChEMBL:

    CHEMBL5095485

    DrugBank:

    DB18993

    KEGG DRUG:

    D12430

    PubChem:

    PubChem

    Disclaimer:

    Retatrutide is an investigational compound not yet approved by FDA or EMA. This listing is for industrial and laboratory research use only. Product information on ECHEMI is provided for sourcing and specification reference. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.

  • Seller Information
    Business Type:

    Trader

    Main Products:

    GLP-1,Retatrutide,Tirzepatide,Peptides

    Location:

    Room A008, 704#, Building 11, Shiliu Street Block, Liangzhu Subdistrict, Yuhang District, Hangzhou City, Zhejiang Province

    Payment Terms:

    TT against copy of documents,100% TT in advance

    Average lead Time:

    1 days

    Total Annual Revenue:

    $1 million-$2.5 million

    Total Employees:

    11-50

    Year of Establishment:

    2025

    Hangzhou Zhongma Trading Co., Ltd. is an international trading company based in Hangzhou, China. We support customers worldwide with product sourcing, order coordination, documentation, packaging options, and logistics arrangements.

    With a focus on clear communication and responsive service, we work closely with supply partners to help customers manage product selection, batch documentation, and delivery requirements. We value long-term cooperation and aim to provide practical, reliable solutions tailored to each customer’s needs.

  • Inquiry History
    7503 Inquiries
    Country Product Purchase Quantity Date Posted
    Malaysia

    Retatrutide

    20 MG Oct 28, 2026
    Australia

    Retaturtide

    100 MG Oct 29, 2026
    United States

    Retatrutide 30mg and 50mg

    20 PCS Oct 29, 2026
    Belgium

    Retatrutide

    1 MG Oct 29, 2026
    Romania

    Retatrutide

    10 G Oct 29, 2026
    United States

    Retatrutide

    2 MT Oct 29, 2026
    United States

    Retatrutide

    1 MT Oct 29, 2026
    United Kingdom

    Retatrutide

    1 PCS Oct 28, 2026
    United States

    Retatrutide

    30 MT Oct 28, 2026
    United Kingdom

    Retatrutide

    10 MT Oct 28, 2026
    United States

    retatrutide

    30 MG Oct 28, 2026
    Czech

    Retatrutide

    10 MG Oct 28, 2026
    Austria

    retatrutide

    30 MG Oct 28, 2026
    United States

    Retatrutide

    100 KG Oct 28, 2026
    Malta

    Retatrutide

    10 MT Oct 28, 2026
    United States

    Retatrutide

    600 MG Oct 28, 2026
    United States

    Retatrutide

    500 G Oct 28, 2026
    United States

    Retatrutide

    60 G Oct 28, 2026
    Croatia

    Retatrutide

    10 MG Oct 28, 2026
    United States

    Retatrutide

    200 MG Oct 28, 2026
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